Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Karen J Shaw"'
Autor:
Leslie W Tari, Xiaoming Li, Michael Trzoss, Daniel C Bensen, Zhiyong Chen, Thanh Lam, Junhu Zhang, Suk Joong Lee, Grayson Hough, Doug Phillipson, Suzanne Akers-Rodriguez, Mark L Cunningham, Bryan P Kwan, Kirk J Nelson, Amanda Castellano, Jeff B Locke, Vickie Brown-Driver, Timothy M Murphy, Voon S Ong, Chris M Pillar, Dean L Shinabarger, Jay Nix, Felice C Lightstone, Sergio E Wong, Toan B Nguyen, Karen J Shaw, John Finn
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84409 (2013)
Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious bacterial infections. The bacterial type IIA t
Externí odkaz:
https://doaj.org/article/61b9ed4eb647499192d901bd0163432e
Publikováno v:
Journal of Fungi, Vol 8, Iss 10, p 1102 (2022)
Invasive fungal infections have mortality rates of 30–90%, depending on patient co-morbidities and the causative pathogen. The frequent emergence of drug resistance reduces the efficacy of currently approved treatment options, highlighting an urgen
Externí odkaz:
https://doaj.org/article/f0e9818d5f574fec88f277d7a86a09bd
Autor:
Michael R. Hodges, Eric Ople, Pamela Wedel, Karen J. Shaw, Abhijeet Jakate, William G. Kramer, Sjoerd van Marle, Ewoud-Jan van Hoogdalem, Margaret Tawadrous
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Fosmanogepix (FMGX, APX001), a first-in-class, intravenous (i.v.) and oral (p.o.) antifungal prodrug candidate is currently in clinical development for the treatment of invasive fungal infections. Manogepix (MGX, APX001A), the active moiety of FMGX,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8519ae4f2f641b726b374191c2ec7bea
https://doi.org/10.1128/aac.01623-22
https://doi.org/10.1128/aac.01623-22
Autor:
Barbara Mermella, Carmita Sanders, Hoja P Patterson, Karen J Shaw, Connie Fe C. Gibas, Nathan P. Wiederhold, Hamid Badali, Ashraf S. Ibrahim
Publikováno v:
Antimicrobial Agents and Chemotherapy. 65
We evaluated the in vitro activity of manogepix against Fusarium oxysporum and Fusarium solani species complex (FOSC and FSSC, respectively) isolates per CLSI document M38 broth microdilution methods. Manogepix demonstrated activity against both FOSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d59609d9c8f00b2166ece8b548bff0d8
https://doi.org/10.1128/aac.02343-20
https://doi.org/10.1128/aac.02343-20
Autor:
Hamid, Badali, Hoja P, Patterson, Carmita J, Sanders, Barbara, Mermella, Connie F C, Gibas, Ashraf S, Ibrahim, Karen J, Shaw, Nathan P, Wiederhold
Publikováno v:
Antimicrob Agents Chemother
We evaluated the in vitro activity of manogepix against Fusarium oxysporum and Fusarium solani species complex (FOSC and FSSC, respectively) isolates per CLSI document M38 broth microdilution methods. Manogepix demonstrated activity against both FOSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5716b65591ce03628881fc9453700f8e
https://pubmed.ncbi.nlm.nih.gov/33722886
https://pubmed.ncbi.nlm.nih.gov/33722886
Autor:
Marcos Olivo, Thomas F. Patterson, Rosie Jaramillo, Hoja P Patterson, Gabriel Catano, Laura K. Najvar, Nathan P. Wiederhold, Karen J Shaw
Publikováno v:
Antimicrobial Agents and Chemotherapy
The emerging pathogenic yeast Candida auris is associated with antifungal resistance and high mortality. The novel antifungal agent manogepix (APX001A) inhibits glycosylphosphatidylinositol-anchored protein maturation and has demonstrated activity ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::836cb97927a70a1c91b53a69525ce467
http://europepmc.org/articles/PMC6811405
http://europepmc.org/articles/PMC6811405
Autor:
Abdullah Alqarihi, Mili Kapoor, Ashraf S. Ibrahim, Sondus Alkhazraji, Teclegiorgis Gebremariam, Yiyou Gu, Heewon H. Jeon, Karen J Shaw
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial agents and chemotherapy, vol 63, iss 2
Antimicrobial agents and chemotherapy, vol 63, iss 2
Invasive pulmonary aspergillosis (IPA) due to Aspergillus fumigatus is a serious fungal infection in the immunosuppressed patient population. Despite the introduction of new antifungal agents, mortality rates remain high, and new treatments are neede
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27630b48be6ac61023424fe0c681a75
http://europepmc.org/articles/PMC6355556
http://europepmc.org/articles/PMC6355556
Autor:
Hongxin Fan, Barbara Mermella, James Mele, Carmita Sanders, Connie Fe C. Gibas, Nathan P. Wiederhold, Hoja P Patterson, Ashraf S. Ibrahim, Hamid Badali, Karen J Shaw
Publikováno v:
Open Forum Infectious Diseases
Background Invasive fusariosis is associated with marked morbidity and mortality in immunocompromised hosts, and treatment options are limited. Common etiologic agents include members of the F. oxysporum and F. solani species complexes (FOSC and FSSC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a619af20d6500ec6c652d2dae043271b
https://doi.org/10.1093/ofid/ofaa439.1465
https://doi.org/10.1093/ofid/ofaa439.1465
Autor:
John R. Perfect, Jennifer L. Tenor, Quinlyn A. Soltow, Jane-Valeriane Boua, Julia R Palmucci, Dena L. Toffaletti, Karen J Shaw, Charles Giamberardino, Choiselle Marius
Publikováno v:
Open Forum Infectious Diseases
Background Cryptococcal meningitis (CM), caused primarily by Cryptococcus neoformans, is uniformly fatal if not treated. Treatment options are limited especially in resource-poor geographical regions, and mortality rates remain high despite current t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ff8a9261f2cec6838274185271281c
https://doi.org/10.1093/ofid/ofaa439.478
https://doi.org/10.1093/ofid/ofaa439.478
Autor:
Karen J. Shaw, Fatima Zohra Abidi, Christopher L. Hager, Lisa Long, Emily L Larkin, Mahmoud A. Ghannoum
Publikováno v:
Antimicrobial Agents and Chemotherapy
Candida auris is an emerging multidrug-resistant yeast that has been responsible for invasive infections associated with high morbidity and mortality. C. auris strains often demonstrate high fluconazole and amphotericin B MIC values, and some strains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ea7bf521ed99f97eed6e90548765607
https://doi.org/10.1128/aac.02319-17
https://doi.org/10.1128/aac.02319-17