Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Karen J Gagnon"'
Autor:
Sven H. Hausner, David L. Kukis, M. Karen J. Gagnon, Catherine E. Stanecki, Riccardo Ferdani, John F. Marshall, Carolyn J. Anderson, Julie L. Sutcliffe
Publikováno v:
Molecular Imaging, Vol 8 (2009)
Significant upregulation of the integrin α v β 6 has been described as a prognostic indicator in several cancers, making it an attractive target for tumor imaging. This study compares variants of a PEGylated α v β 6 -targeting peptide, bearing ei
Externí odkaz:
https://doaj.org/article/6f6b4575e93d469e99ad93a943a6c830
Autor:
Eric E. Paoli, Robert D. Cardiff, Katherine W. Ferrara, Elizabeth S. Ingham, Hua Zhang, M. Karen J. Gagnon, Sarah Tam, Azadeh Kheirolomoom, Brett Z. Fite, Lisa M. Mahakian
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society, vol 178, iss 1
Advancements in liposomal drug delivery have produced long circulating and very stable drug formulations. These formulations minimize systemic exposure; however, unfortunately, therapeutic efficacy has remained limited due to the slow diffusion of li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::244bfbaade159ec0e52da20308c5aeb7
https://doi.org/10.1016/j.jconrel.2014.01.005
https://doi.org/10.1016/j.jconrel.2014.01.005
Autor:
Katherine W. Ferrara, M. Karen J. Gagnon, Hua Zhang, Tingrui Pan, Scott I. Simon, Jiro Kusunose
Publikováno v:
Annals of Biomedical Engineering. 41:89-99
The identification of novel, synthetic targeting ligands to endothelial receptors has led to the rapid development of targeted nanoparticles for drug, gene and imaging probe delivery. Central to development and optimization are effective models for a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c6d1dd75e7bbe8ca6270a49aa0c9784
https://doi.org/10.1007/s10439-012-0634-0
https://doi.org/10.1007/s10439-012-0634-0
Autor:
M. Karen J. Gagnon, Valentina Fogal, Jai Woong Seo, Lilach Agemy, Venkata Ramana Kotamraju, Katherine W. Ferrara, Juliana Hamzah, Lisa M. Mahakian, Lise Roth, David Peters, Erkki Ruoslahti
Publikováno v:
Proceedings of the National Academy of Sciences. 108:7154-7159
The ability to selectively deliver compounds into atherosclerotic plaques would greatly benefit the detection and treatment of atherosclerotic disease. We describe such a delivery system based on a 9-amino acid cyclic peptide, LyP-1. LyP-1 was origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90b571599f22ea4923821a5d2831266c
https://doi.org/10.1073/pnas.1104540108
https://doi.org/10.1073/pnas.1104540108
Autor:
Jan Marik, Craig K. Abbey, Sven H. Hausner, Julie L. Sutcliffe, Cathy E. Stanecki, Richard J. Bold, John Marshall, M. Karen J. Gagnon
Publikováno v:
Cancer Research. 69:5843-5850
The cell surface receptor αvβ6 is epithelial specific, and its expression is tightly regulated; it is low or undetectable in adult tissues but has been shown to be increased in many different cancers, including pancreatic, cervical, lung, and colon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9871143be7ad0f0321c80089657c7063
https://doi.org/10.1158/0008-5472.can-08-4410
https://doi.org/10.1158/0008-5472.can-08-4410
Publikováno v:
Journal of Medicinal Chemistry. 51:5901-5904
Numerous radiolabeled peptides have been utilized for in vivo imaging of a variety of cell surface receptors. For applications in PET using [18F]fluorine, peptides are radiolabeled via a prosthetic group approach. We previously developed solution-pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::98b57208dfdf8f13b3f87ed9fabc87b8
https://doi.org/10.1021/jm800608s
https://doi.org/10.1021/jm800608s
Autor:
Dong Ju Son, Sandeep Kumar, Chan Woo Kim, Jai Woong Seo, Katherine W. Ferrara, Hanjoong Jo, Azadeh Kheirolomoom, Elizabeth S. Ingham, M. Karen J. Gagnon
Publikováno v:
ACS Nano
The current study presents an effective and selective multifunctional nanoparticle used to deliver antiatherogenic therapeutics to inflamed pro-atherogenic regions without off-target changes in gene expression or particle-induced toxicities. MicroRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5adf804c1f7e31df46bd661876c10068
https://pubmed.ncbi.nlm.nih.gov/26308181
https://pubmed.ncbi.nlm.nih.gov/26308181
Publikováno v:
Bioconjugate Chemistry. 17:1017-1021
The 2-[(18)F]fluoropropionic (2-[(18)F]FPA) acid is used as a prosthetic group for radiolabeling proteins and peptides for targeted imaging using positron emission tomography (PET). Radiolabeling of compounds with more than one acylable functional gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fff9b92a7371e508de1759aeb49ab966
https://doi.org/10.1021/bc0600564
https://doi.org/10.1021/bc0600564
Autor:
Tom L. Broderick, John R. Bailey, Stephen A. Westcott, Karen J Gagnon, Sarah J Lord, Christopher M. Vogels
Publikováno v:
Drugs in R & D. 7:119-125
Background: The insulin-like action of metal complexes on target tissues, including the heart, has been reported in experimental diabetes mellitus. Since streptozotocin-induced diabetes is associated with insulin deficiency and left ventricular dysfu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05064c4615b9c98c18f9a63a7c18c497
https://doi.org/10.2165/00126839-200607020-00006
https://doi.org/10.2165/00126839-200607020-00006
Autor:
Fitz Roy E Curry, Brett Z. Fite, M. Karen J. Gagnon, Jai Woong Seo, Frits Thorsen, Shengping Qin, Katherine W. Ferrara
Our goal is to provide a physiological perspective on the use of imaging to optimize and monitor the accumulation of nanotherapeutics within target tissues, with an emphasis on evaluating the pharmacokinetics of organic particles. Positron emission t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4e5f6e71bd2cc5615f3215e5cf2ee6
https://europepmc.org/articles/PMC3943857/
https://europepmc.org/articles/PMC3943857/
