Zobrazeno 1 - 10
of 169
pro vyhledávání: '"Karen J, Kirkby"'
Autor:
Nickolay Korabel, John W. Warmenhoven, Nicholas T. Henthorn, Samuel Ingram, Sergei Fedotov, Charlotte J. Heaven, Karen J. Kirkby, Michael J. Taylor, Michael J. Merchant
Publikováno v:
Entropy, Vol 26, Iss 6, p 502 (2024)
The process of end-joining during nonhomologous repair of DNA double-strand breaks (DSBs) after radiation damage is considered. Experimental evidence has revealed that the dynamics of DSB ends exhibit subdiffusive motion rather than simple diffusion
Externí odkaz:
https://doaj.org/article/b1ffe8c2c55749f8912a4a623ebb2857
Autor:
Samuel P. Ingram, John-William Warmenhoven, Nicholas T. Henthorn, Amy L. Chadiwck, Elham E. Santina, Stephen J. McMahon, Jan Schuemann, Norman F. Kirkby, Ranald I. Mackay, Karen J. Kirkby, Michael J. Merchant
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
PyFoci is a tool that simulates distributions of fluorescently labeled DNA double-strand break marker protein foci and allows the estimation of miscounting under different radiation types, doses and microscopy settings.
Externí odkaz:
https://doaj.org/article/12f2d24396fc42b6b08bfd133060527c
Autor:
Emma R. Biglin, Adam H. Aitkenhead, Gareth J. Price, Amy L. Chadwick, Elham Santina, Kaye J. Williams, Karen J. Kirkby
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Preclinical radiation research lacks standardized dosimetry procedures that provide traceability to a primary standard. Consequently, ensuring accuracy and reproducibility between studies is challenging. Using 3D printed murine phantoms we u
Externí odkaz:
https://doaj.org/article/837936469b87449c8bfd74544c4248a6
Autor:
Bethany C. Rothwell, Matthew Lowe, Norman F. Kirkby, Michael J. Merchant, Amy L. Chadwick, Ranald I. Mackay, Jolyon H. Hendry, Karen J. Kirkby
Publikováno v:
Radiation, Vol 1, Iss 4, Pp 290-304 (2021)
FLASH radiotherapy is a rapidly developing field which promises improved normal tissue protection compared to conventional irradiation and no compromise on tumour control. The transient hypoxic state induced by the depletion of oxygen at high dose ra
Externí odkaz:
https://doaj.org/article/afdfad777b8f45178f2f1629ab81806f
Autor:
Emma R. Biglin, Gareth J. Price, Amy L. Chadwick, Adam H. Aitkenhead, Kaye J. Williams, Karen J. Kirkby
Publikováno v:
Radiation Oncology, Vol 14, Iss 1, Pp 1-10 (2019)
Abstract Preclinical radiotherapy studies using small animals are an indispensable step in the pathway from in vitro experiments to clinical implementation. As radiotherapy techniques advance in the clinic, it is important that preclinical models evo
Externí odkaz:
https://doaj.org/article/f446a7dfc65f4a6790c49cdf71d6849c
Autor:
Samuel P Ingram, Nicholas T Henthorn, John W Warmenhoven, Norman F Kirkby, Ranald I Mackay, Karen J Kirkby, Michael J Merchant
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 12, p e1008476 (2020)
Developments in the genome organisation field has resulted in the recent methodology to infer spatial conformations of the genome directly from experimentally measured genome contacts (Hi-C data). This provides a detailed description of both intra- a
Externí odkaz:
https://doaj.org/article/bca859834a4142c2833468df353a8cd5
Autor:
Nicholas T. Henthorn, Olga Sokol, Marco Durante, Ludovic De Marzi, Frederic Pouzoulet, Justyna Miszczyk, Pawel Olko, Sytze Brandenburg, Marc Jan van Goethem, Lara Barazzuol, Makbule Tambas, Johannes A. Langendijk, Marie Davídková, Vladimír Vondráĉek, Elisabeth Bodenstein, Joerg Pawelke, Antony J. Lomax, Damien C. Weber, Alexandru Dasu, Bo Stenerlöw, Per R. Poulsen, Brita S. Sørensen, Cai Grau, Mateusz K. Sitarz, Anne-Catherine Heuskin, Stephane Lucas, John W. Warmenhoven, Michael J. Merchant, Ran I. Mackay, Karen J. Kirkby
Publikováno v:
Frontiers in Physics, Vol 8 (2020)
Particle therapy is a growing cancer treatment modality worldwide. However, there still remains a number of unanswered questions considering differences in the biological response between particles and photons. These questions, and probing of biologi
Externí odkaz:
https://doaj.org/article/88275246ca1f4bacb94b8d81b66f3077
Autor:
Charlotte J Heaven, Hannah C Wanstall, Nicholas T Henthorn, John-William Warmenhoven, Samuel P Ingram, Amy L Chadwick, Elham Santina, Jamie Honeychurch, Christine K Schmidt, Karen J Kirkby, Norman F Kirkby, Neil G Burnet, Michael J Merchant
Publikováno v:
Heaven, C J, Wanstall, H C, Henthorn, N T, Warmenhoven, J-W, Ingram, S P, Chadwick, A L, Santina, E, Honeychurch, J, Schmidt, C K, Kirkby, K J, Kirkby, N F, Burnet, N G & Merchant, M J 2022, ' The suitability of micronuclei as markers of relative biological effect ', Mutagenesis, vol. 37, no. 1, pp. 3-12 . https://doi.org/10.1093/mutage/geac001
Mutagenesis
Mutagenesis
Micronucleus (MN) formation is routinely used as a biodosimeter for radiation exposures and has historically been used as a measure of DNA damage in cells. Strongly correlating with dose, MN are also suggested to indicate radiation quality, different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49bf05d1313e5ad799a37f6ed467a7d
https://doi.org/10.1093/mutage/geac001
https://doi.org/10.1093/mutage/geac001
Autor:
Nicholas T. Henthorn, Lydia L. Gardner, Adam H. Aitkenhead, Benjamin C. Rowland, Jungwook Shin, Edward A.K. Smith, Michael J. Merchant, Ranald I. Mackay, Karen J. Kirkby, Pankaj Chaudhary, Kevin M. Prise, Stephen J. McMahon, Tracy S.A. Underwood
Publikováno v:
International Journal of Radiation Oncology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2925ee65ebab470a9f7301e0b842ac4d
https://doi.org/10.1016/j.ijrobp.2022.12.056
https://doi.org/10.1016/j.ijrobp.2022.12.056
Autor:
Karen J. Kirkby, Ranald I Mackay, Matthew Lowe, Bethany C Rothwell, Jolyon H Hendry, Neil G. Burnet, Norman F. Kirkby
Publikováno v:
Radiotherapy and Oncology. 164:122-127
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b8e9dccc0d1d25adf2ac98411656f7
https://doi.org/10.1016/j.radonc.2021.09.011
https://doi.org/10.1016/j.radonc.2021.09.011