Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karen I. Guerin"'
Autor:
Leila Haery, Benjamin E. Deverman, Katherine S. Matho, Ali Cetin, Kenton Woodard, Connie Cepko, Karen I. Guerin, Meghan A. Rego, Ina Ersing, Susanna M. Bachle, Joanne Kamens, Melina Fan
Publikováno v:
Frontiers in Neuroanatomy, Vol 13 (2019)
Cell-type-specific expression of molecular tools and sensors is critical to construct circuit diagrams and to investigate the activity and function of neurons within the nervous system. Strategies for targeted manipulation include combinations of cla
Externí odkaz:
https://doaj.org/article/90ca0514a27c4b6db547d1642d1d9e06
Autor:
Scott F Geller, Karen I Guerin, Meike Visel, Aaron Pham, Edwin S Lee, Amiel A Dror, Karen B Avraham, Toshinori Hayashi, Catherine A Ray, Thomas A Reh, Olivia Bermingham-McDonogh, William J Triffo, Shaowen Bao, Juha Isosomppi, Hanna Västinsalo, Eeva-Marja Sankila, John G Flannery
Publikováno v:
PLoS Genetics, Vol 5, Iss 8, p e1000607 (2009)
Mutations in the CLRN1 gene cause Usher syndrome type 3 (USH3), a human disease characterized by progressive blindness and deafness. Clarin 1, the protein product of CLRN1, is a four-transmembrane protein predicted to be associated with ribbon synaps
Externí odkaz:
https://doaj.org/article/5b0b5b895c4640a499371880eb763eef
Autor:
Karen I. Guerin, Luke Hanley, Leila Haery, Ina Ersing, Meghan A. Rego, Erin Sanders, Melina Fan, Isabelle Mueller, Meron Tasissa
Hyperosmolarity has been used as a means to improve yields in various processes such as antibody production in hybridoma cells and retroviral and adenoviral production systems. In this study we demonstrate that treatment of AAVpro 293T packaging cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e7a99445ba42cb7fae8f87a22d8df2b
Autor:
Matthew Campbell, Roberta J. Dennison, Lois E.H. Smith, Aimee M. Juan, Akiko Mammoto, Jing Chen, Karen I. Guerin, C. M. Aderman, Keirnan L. Willett, Nathan M. Krah, Przemyslaw Sapieha, Colman J. Hatton, Jing Hua, Andreas Stahl, Molly R. Seaward
Publikováno v:
Circulation. 124:1871-1881
Background— Ischemic proliferative retinopathy, characterized by pathological retinal neovascularization, is a major cause of blindness in working-age adults and children. Defining the molecular pathways distinguishing pathological neovascularizati
Autor:
Karen I. Guerin, Nathan M. Krah, Przemyslaw Sapieha, Molly R. Seaward, Jing Chen, Roberta J. Dennison, Jing Hua, Lois E.H. Smith, Kip M. Connor, John Paul SanGiovanni, C. M. Aderman, Andreas Stahl, Keirnan L. Willett
Publikováno v:
Circulation Research. 107:495-500
Rationale: Omega3 long-chain polyunsaturated fatty acids (ω3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing ω3-PUFA–dependent attenuation of angiogenesis. Objective: This study aims to iden
Autor:
Nathan M. Krah, Karen I. Guerin, Kip M. Connor, C. M. Aderman, Keirnan L. Willett, Lois E.H. Smith, Andreas Stahl, Roberta J. Dennison, Przemyslaw Sapieha, Jing Chen
Publikováno v:
Nature Protocols. 4:1565-1573
The mouse model of oxygen-induced retinopathy (OIR) has been widely used in studies related to retinopathy of prematurity, proliferative diabetic retinopathy and in studies evaluating the efficacy of antiangiogenic compounds. In this model, 7-d-old (
Autor:
Keirnan L. Willett, Kip M. Connor, Roberta J. Dennison, Jing Chen, Lois E.H. Smith, Andreas Stahl, Przemyslaw Sapieha, Karen I. Guerin, Nathan M. Krah
Publikováno v:
Angiogenesis. 12:297-301
Rodent models of retinal angiogenesis play a pivotal role in angiogenesis research. These models are a window to developmental angiogenesis, to pathological retinopathy, and are also in vivo tools for anti-angiogenic drug screening in cancer and opht
Autor:
Marshall G. Miller, Joanne S. Allard, Edoardo Parrella, Ying Li, Huanying Ge, Michael W. McBurney, David A. Sinclair, Maggie Meng Hsiu Chou, Karen I. Guerin, Jeffrey M. Long, Ronald F. Mervis, Jing Chen, Kaitlyn N. Lewis, Michel Baudry, Valter D. Longo, Shaday Michan, Rafael de Cabo, Lois E.H. Smith, Wei Xu
Conservation of normal cognitive functions relies on the proper performance of the nervous system at the cellular and molecular level. The mammalian nicotinamide-adenine dinucleotide-dependent deacetylase SIRT1 impacts different processes potentially
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8739b718b56d0c09d5291c7e99545e16
http://hdl.handle.net/11379/500877
http://hdl.handle.net/11379/500877
Autor:
David A. Sinclair, Jing Chen, Molly R. Seaward, Aimee M. Juan, Jing Hua, Roberta J. Dennison, Shaday Michan, Przemyslaw Sapieha, Colman J. Hatton, Andreas Stahl, Lois E.H. Smith, Karen I. Guerin, Nathan M. Krah
Publikováno v:
Investigative Opthalmology & Visual Science. 52:2809
Abnormal retinal angiogenesis and choroidal angiogenesis are common causes of vision loss.1 Macular telangiectasia (MacTel), also known as idiopathic parafoveal telangiectasia, is a retinal neovascular disease in which there is abnormal retinal neova
Autor:
Keirnan L. Willett, Przemyslaw Sapieha, C. M. Aderman, Roberta J. Dennison, Ann Hellström, Jing Hua, Kip M. Connor, Molly R. Seaward, Chatarina Löfqvist, Jing Chen, Nathan M. Krah, Andreas Stahl, Karen I. Guerin, Lois E.H. Smith
Publikováno v:
Investigative Opthalmology & Visual Science. 51:2813
The mouse retina has been used extensively over the past decades to study both physiologic and pathologic angiogenesis. Over time, various mouse retina models have evolved into well-characterized and robust tools for in vivo angiogenesis research. Th