Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Karen Horsburgh"'
Autor:
Yoshiki Hase, Dan Jobson, Jeremy Cheong, Kelvin Gotama, Luciana Maffei, Mai Hase, Alhafidz Hamdan, Ren Ding, Tuomo Polivkoski, Karen Horsburgh, Raj N. Kalaria
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-14 (2024)
Abstract Neurovascular unit mural cells called ‘pericytes’ maintain the blood-brain barrier and local cerebral blood flow. Pathological changes in the hippocampus predispose to cognitive impairment and dementia. The role of hippocampal pericytes
Externí odkaz:
https://doaj.org/article/87ba1b72c1c841c88a75ca6ccd1a72f8
Autor:
Anirudh Patir, Jack Barrington, Stefan Szymkowiak, Gaia Brezzo, Dana Straus, Alessio Alfieri, Lucas Lefevre, Zhaoyuan Liu, Florent Ginhoux, Neil C. Henderson, Karen Horsburgh, Prakash Ramachandran, Barry W. McColl
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114250- (2024)
Summary: Acute stroke triggers extensive changes to myeloid immune cell populations in the brain that may be targets for limiting brain damage and enhancing repair. Immunomodulatory approaches will be most effective with precise manipulation of discr
Externí odkaz:
https://doaj.org/article/46d376e2692d4f81af120919f30960d0
Autor:
Stefan Szymkowiak, Mila Redzic, Anirudh Patir, Clare Latta, Michael Daniels, Jack Barrington, Katie Askew, Jessica Duncombe, Karen Horsburgh, Barry McColl
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100318- (2024)
Cerebrovascular disease is a major contributor to subcortical white matter pathology, vascular cognitive impairment (VCI) and dementia. Although the precise pathophysiological mechanisms remain unclear, it is increasingly evident that microglial resp
Externí odkaz:
https://doaj.org/article/e444c4a1dac84144a720f0a658b27646
Publikováno v:
Cerebral Circulation - Cognition and Behavior, Vol 6, Iss , Pp 100093- (2024)
Externí odkaz:
https://doaj.org/article/60ac0539940e409986e62881125f4ec2
Publikováno v:
Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-15 (2020)
Abstract Background Chronic cerebral hypoperfusion causes damage to the brain’s white matter underpinning vascular cognitive impairment. Inflammation and oxidative stress have been proposed as key pathophysiological mechanisms of which the transcri
Externí odkaz:
https://doaj.org/article/7e3e2881787e4c44b3dfb9692b7f07a6
Autor:
Mosi Li, Akihiro Kitamura, Joshua Beverley, Juraj Koudelka, Jessica Duncombe, Ross Lennen, Maurits A. Jansen, Ian Marshall, Bettina Platt, Ulrich K. Wiegand, Roxana O. Carare, Rajesh N. Kalaria, Jeffrey J. Iliff, Karen Horsburgh
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2022)
Large vessel disease and carotid stenosis are key mechanisms contributing to vascular cognitive impairment (VCI) and dementia. Our previous work, and that of others, using rodent models, demonstrated that bilateral common carotid stenosis (BCAS) lead
Externí odkaz:
https://doaj.org/article/24b532b621764d6c85fdb1fb3b919ba1
Autor:
Emma Sigfridsson, Martina Marangoni, Jeffrey A. Johnson, Giles E. Hardingham, Jill H. Fowler, Karen Horsburgh
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract Mouse models have shown that cerebral hypoperfusion causes white matter disruption and memory impairment relevant to the study of vascular cognitive impairment and dementia. The associated mechanisms include inflammation and oxidative stress
Externí odkaz:
https://doaj.org/article/d600fb320b054084b56284ae738c586b
Autor:
Akihiro Kitamura, Yasmina Manso, Jessica Duncombe, James Searcy, Juraj Koudelka, Margaret Binnie, Scott Webster, Ross Lennen, Maurits Jansen, Ian Marshall, Masafumi Ihara, Raj N. Kalaria, Karen Horsburgh
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract Chronic cerebral hypoperfusion is a major cause of age-related vascular cognitive impairment. A well-characterised mouse model has shown that hypoperfusion results in gliovascular and white matter damage and impaired spatial working memory.
Externí odkaz:
https://doaj.org/article/a99c822285fe43d893ff1f0c5c5d7bd5
Autor:
Yoshiki Hase, Lucinda Craggs, Mai Hase, William Stevenson, Janet Slade, Dianne Lopez, Rubin Mehta, Aiqing Chen, Di Liang, Arthur Oakley, Masafumi Ihara, Karen Horsburgh, Raj N. Kalaria
Publikováno v:
Journal of Neuroinflammation, Vol 14, Iss 1, Pp 1-14 (2017)
Abstract Background This study was designed to explore the beneficial effects of environmental enrichment (EE) on white matter glial changes in a mouse model of chronic cerebral hypoperfusion induced by bilateral common carotid artery stenosis (BCAS)
Externí odkaz:
https://doaj.org/article/5d6acc1b38e24934905ffae21d50fff0
Autor:
Sandra Magnoni, Andrew Baker, Sarah Jane George, W. Colin Duncan, Lorraine E. Kerr, James McCulloch, Karen Horsburgh
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 2, Pp 188-197 (2004)
Abnormal expression and activity of matrix metalloproteinases (MMPs) may contribute to the pathophysiology of cerebral disease such as ischemic injury. In this study, we compared the cellular localization, expression, and activity of MMP-2 and -9 in
Externí odkaz:
https://doaj.org/article/d4de247de6d64ceba5963d1c0039b810