Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Karen Hinsinger"'
Autor:
Karen Hinsinger, Christophe Dugave
Publikováno v:
Impact
Impact, 2017, 2017 (8), pp.52-54. ⟨10.21820/23987073.2017.8.52⟩
Impact, 2017, 2017 (8), pp.52-54. ⟨10.21820/23987073.2017.8.52⟩
International audience; ISOTOPICS (H2020 - Marie Sklodowska-Curie Actions - Innovative Training Network; grant number 675071) combines researchers and industry in an innovative effort to de-risk drug development, create new tools for medicine and tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f9d816ea268b92df9321fc1f44c8df
https://doi.org/10.21820/23987073.2017.8.52
https://doi.org/10.21820/23987073.2017.8.52
Autor:
Véronique Leignel, Neetu Gupta, Eric Oswald, Sandrine Cojean, Thomas Rudel, Yasuteru Sakurai, Ayaka Shima, Thomas Secher, Julien Barbier, Annette Fischer, Ludger Johannes, Olena Shtanko, Jo-Ana Herweg, Karen Hinsinger, Vanessa Liévin-Le Moal, Hajer Abdelkafi, Daniel Gillet, Kate Harrison, Joël Vacus, Livia Tepshi, Romain Noel, Robert A. Davey, Jean-Christophe Cintrat, Amélie Goudet, Philippa M. Beard, Valérie Pons, Philippe M. Loiseau, Aurélien Michau, Sébastien Pomel
Publikováno v:
Toxicon. 149:96-97
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23ab952c544081f5478fb52ea8f1e39e
https://doi.org/10.1016/j.toxicon.2017.12.036
https://doi.org/10.1016/j.toxicon.2017.12.036
Autor:
Christopher McGuigan, Joachim Jakob Bugert, Karen Hinsinger, Laura Farleigh, Ranjith N. Pathirana
Publikováno v:
Journal of Medicinal Chemistry. 56:1311-1322
Dideoxy bicyclic pyrimidine nucleoside analogues (ddBCNAs) with d-chirality have previously been described by us to inhibit replication of human cytomegalovirus. We herein report for the first time that activity against vaccinia virus (VACV) was achi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e115fd1c2a35a4708cb8a8f065840ae
https://doi.org/10.1021/jm301778x
https://doi.org/10.1021/jm301778x
Autor:
Eric Oswald, Roger Le Grand, Véronique Leignel, Ludger Johannes, Annette Fischer, Thomas Secher, Sandrine Cojean, Robert A. Davey, Romain Noel, Philippa M. Beard, Kate Harrison, Thomas Rudel, Yasuteru Sakurai, A. Shima, Olena Shtanko, Karen Hinsinger, Julien Barbier, Vanessa Liévin-Le Moal, Jean-Christophe Cintrat, Sébastien Pomel, Jo-Ana Herweg, Hajer Abdelkafi, Amélie Goudet, Jon O. Rayner, Philippe M. Loiseau, Pascal Clayette, Valérie Pons, Neetu Gupta, Aurélien Michau, Daniel Gillet, Joël Vacus
Publikováno v:
Chemico-Biological Interactions. 267
Medical countermeasures to treat biothreat agent infections require broad-spectrum therapeutics that do not induce agent resistance. A cell-based high-throughput screen (HTS) against ricin toxin combined with hit optimization allowed selection of a f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a7ba42bd4546cba63b04f0ff30c0981
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Autor:
Thomas Secher, Ludger Johannes, Julien Barbier, Karen Hinsinger, A. Shima, Eric Oswald, Jean-Christophe Cintrat, Daniel Gillet
Publikováno v:
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2015, 59 (8), pp.5010-5013. ⟨10.1128/AAC.00455-15⟩
Antimicrobial Agents and Chemotherapy, 2015, 59 (8), pp.5010-5013. ⟨10.1128/AAC.00455-15⟩
Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2015, 59 (8), pp.5010-5013. ⟨10.1128/AAC.00455-15⟩
Antimicrobial Agents and Chemotherapy, 2015, 59 (8), pp.5010-5013. ⟨10.1128/AAC.00455-15⟩
The most deadly outbreak of Escherichia coli O104:H4 occurred in Europe in 2011. Here, we evaluated the effects of the retrograde trafficking inhibitor Retro-2 cycl in a murine model of E. coli O104:H4 infection. Systemic treatment with Retro-2 cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77598a83b508bcf5d8a3fff135624be9
https://europepmc.org/articles/PMC4505253/
https://europepmc.org/articles/PMC4505253/
Autor:
Robert Snoeck, Ernest Akorli, Arundhati Maitra, Karen Hinsinger, Sahar Kandil, Sanjib Bhakta, Fabrizio Pertusati, Blanka Gonczy, Timothy D. McHugh, Dimitrios Evangelopoulos, Marco Derudas, Michaela Serpi, Christopher McGuigan, Graciela Andrei, Jan Balzarini
Publikováno v:
Bioorganicmedicinal chemistry. 22(9)
The flavin-dependent thymidylate synthase X (ThyX), rare in eukaryotes and completely absent in humans, is crucial in the metabolism of thymidine (a DNA precursor) in many microorganisms including several human pathogens. Conserved in mycobacteria, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::557a2b31bfcf00cb4cd4eab3af7bcb2c
https://pubmed.ncbi.nlm.nih.gov/24690527
https://pubmed.ncbi.nlm.nih.gov/24690527
Autor:
Amanda Jane Tristram, Karen Hinsinger, Ned George Powell, Áine Sinéad Flynn, Fabrizio Pertusati, Christopher McGuigan, Jan Balzarini
Publikováno v:
European journal of medicinal chemistry. 78
The synthesis and in vitro biological evaluation of novel phosphonamidate and phosphonodiamidate prodrugs of adefovir and tenofovir are reported. The selected synthetic approach from free phosphonic acid via bis-trimethylsilyl ester intermediates aff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66071dd6dc55ad6e9362f69ab1435e1d
https://pubmed.ncbi.nlm.nih.gov/24686012
https://pubmed.ncbi.nlm.nih.gov/24686012
Autor:
Marco Derudas, Stanley D. Chamberlain, Michaela Serpi, Silvia Meneghesso, Christopher McGuigan, Claire Bourdin, Christophe Vanpouille, Nadège Hamon, Andrea Introini, Karen Hinsinger, Sahar Kandil, Leonid Margolis, Magdalena Slusarczyk, Fabrizio Pertusati, John Vernachio, Alexander A. Kolykhalov, Jan Balzarini, Karolina Madela
Publikováno v:
European Journal of Medicinal Chemistry
We herein report the application of the phosphorodiamidate phosphate prodrug approach to a series of thirteen nucleoside analogs with antiviral or anticancer activity. Twenty-five symmetrical phosphorodiamidates were synthesized, bearing esterified l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbba1960a9d171de1497e967d275061d
https://europepmc.org/articles/PMC4358806/
https://europepmc.org/articles/PMC4358806/
Autor:
Didier Le Nouen, Sandy Desrat, Théophile Tschamber, Morgan Donnard, Karen Hinsinger, Jacques Eustache
Publikováno v:
ChemInform. 42
Examples for functionalization of the substrates either prior to the metathesis reaction or following it are additionally given to demonstrate the value of this method for the preparation of nonclassical saccharides.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72a2d91f70ca80f6bbc4a0049ce720db
https://doi.org/10.1002/chin.201119048
https://doi.org/10.1002/chin.201119048
Autor:
Sandy Desrat, Morgan Donnard, Didier Le Nouen, Théophile Tschamber, Jacques Eustache, Karen Hinsinger
Publikováno v:
Tetrahedron
Tetrahedron, Elsevier, 2011, 67 (2), pp.339-357. ⟨10.1016/j.tet.2010.11.036⟩
Tetrahedron, 2011, 67 (2), pp.339-357. ⟨10.1016/j.tet.2010.11.036⟩
Tetrahedron, Elsevier, 2011, 67 (2), pp.339-357. ⟨10.1016/j.tet.2010.11.036⟩
Tetrahedron, 2011, 67 (2), pp.339-357. ⟨10.1016/j.tet.2010.11.036⟩
The rearrangement of dihydropyrans and dihydrofurans featuring appending olefins has been studied. The rearranged products bear resemblance with polyunsaturated di- and trisaccharides. Examples of functionalization prior to, or following, rearrangeme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41269c8cded5b707906627588eebf988
https://hal.archives-ouvertes.fr/hal-02319563
https://hal.archives-ouvertes.fr/hal-02319563