Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Karen Hellauer"'
Publikováno v:
Journal of Biological Chemistry. 277:17671-17676
The yeast PDR5 gene encodes an efflux pump that confers multidrug resistance. Expression of PDR5 is positively regulated by the transcription factors Pdr1p and Pdr3p that recognize the same pleiotropic drug resistance elements (PDREs) in the PDR5 pro
Publikováno v:
Molecular and Cellular Biology. 16:6096-6102
The Gal4, Put3, and Ppr1 yeast zinc cluster proteins bind as homodimers to DNA sequences composed of palindromic CGG triplets. Spacing between the triplets specifies the target site for a given zinc cluster protein. In addition, Hap1p, another zinc c
Publikováno v:
Genetics. 188(3)
In Saccharomyces cerevisiae, optimal utilization of various compounds as a nitrogen source is mediated by a complex transcriptional network. The zinc cluster protein Dal81 is a general activator of nitrogen metabolic genes, including those for Γ-ami
Publikováno v:
Molecular pharmacology. 68(5)
Tirapazamine (TPZ) is an anticancer drug that targets topoisomerase II. TPZ is preferentially active under hypoxic conditions. The drug itself is not harmful to cells; rather, it is reduced to a toxic radical species by an NADPH cytochrome P450 oxido
Publikováno v:
The Journal of biological chemistry. 276(17)
Chromatin plays an important role in regulating eukaryotic gene expression. Chromatin is composed of DNA wrapped around a nucleosome core (consisting of two copies of the well conserved histones H2A, H2B, H3, and H4) and a more variable linker histon
Publikováno v:
Nucleic acids research. 28(4)
Hap1 is a yeast transcriptional activator which controls expression of genes such as CYC1 and CYC7. Our results show that Hap1 activity is dependent on a functional chromatin remodeling complex SWI/SNF. Using a modified two-hybrid screen with Hap1 as
Publikováno v:
The Journal of biological chemistry. 273(29)
Yeast zinc cluster proteins form a major class of yeast transcriptional regulators. They usually bind as homodimers to target DNA sequences, with each monomer recognizing a CGG triplet. Orientation and spacing between the CGG triplet specifies the re
The yeast zinc cluster protein HAP1, a member of the GAL4 family, is a transcriptional activator that binds as a homodimer to target DNA sequences. These targets include the upstream activating sequences of the CYC1 and CYC7 genes, which have no obvi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108fcdd8b7fea3b65ad01ef8547041ba
https://europepmc.org/articles/PMC145800/
https://europepmc.org/articles/PMC145800/