Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Karen Hayton"'
Autor:
Thomas E. Wellems, Janni Papakrivos, Peter C. Dumoulin, Bruce L. Henschen, Anna Liu, Karen Hayton
Publikováno v:
Molecular and Biochemical Parasitology. 187:103-110
Aotus nancymaae, the owl monkey, provides a useful laboratory model for research to develop drugs and vaccines against human falciparum malaria; however, many Plasmodium falciparum parasites are unable to invade A. nancymaae erythrocytes, rendering t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47763e050ab68246ede1a770578f3783
https://doi.org/10.1016/j.molbiopara.2012.12.005
https://doi.org/10.1016/j.molbiopara.2012.12.005
Autor:
Jian Li, Karen Hayton, Vivek Gopalan, Gilean McVean, Sudhir Varma, Bruce L. Henschen, Ming Yi, Martine Zilversmit, Philip Awadalla, Xin-zhuan Su, Thomas E. Wellems, Vijayaraj Nagarajan, Hongying Jiang, Robert M. Stephens, Na Li, Jianbing Mu
Publikováno v:
Genome Biology
BACKGROUND: The human malaria parasite Plasmodium falciparum survives pressures from the host immune system and antimalarial drugs by modifying its genome. Genetic recombination and nucleotide substitution are the two major mechanisms that the parasi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38a25aa59a509375d60f3e6ec131727b
https://doi.org/10.1186/gb-2011-12-4-r33
https://doi.org/10.1186/gb-2011-12-4-r33
Publikováno v:
Journal of Clinical Investigation. 119:2496-2505
Malaria continues to exert a tremendous health burden on human populations, reflecting astonishingly successful adaptations of the causative Plasmodium parasites. We discuss here how this burden has driven the natural selection of numerous polymorphi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e23784d8d8d089761ccbc6d850ce7fe
https://doi.org/10.1172/jci38307
https://doi.org/10.1172/jci38307
Autor:
Karen Hayton, Xin-zhuan Su
Publikováno v:
Current Genetics. 54:223-239
Drug resistance in malaria parasites is a serious public health burden, and resistance to most of the antimalarial drugs currently in use has been reported. A better understanding of the molecular mechanisms of drug resistance is urgently needed to s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32be9ea697e340daa54f0710ea518353
https://doi.org/10.1007/s00294-008-0214-x
https://doi.org/10.1007/s00294-008-0214-x
Autor:
Thomas J. Templeton, Karen Hayton
Publikováno v:
Molecular Microbiology. 67:236-240
Summary The apicomplexa are parasitic protozoa that are responsible for important human and animal diseases, including malaria, toxoplasmosis, cryptosporidiosis, coccidiosis and babesiosis. Like other members of the superphylum Alveolata, apicomplexa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fcb3d3fd0f594452a965ac7b23b202c
https://doi.org/10.1111/j.1365-2958.2007.06062.x
https://doi.org/10.1111/j.1365-2958.2007.06062.x
Autor:
Lanxuan Doan, Godfrey Lisk, David A. Hill, Karen Hayton, Ajay Pillai, Sanjay A. Desai, Fatima Nawaz
Publikováno v:
Proceedings of the National Academy of Sciences. 104:1063-1068
Erythrocytes infected with malaria parasites exhibit marked increases in permeability to organic and inorganic solutes. The plasmodial surface anion channel (PSAC), an unusual voltage-dependent ion channel induced on the host membrane after infection
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db3b21582725f035a75e7c758cd7764
https://doi.org/10.1073/pnas.0610353104
https://doi.org/10.1073/pnas.0610353104
Autor:
Zamin Iqbal, Michel Theron, Paul Vauterin, Kelda Gould, Susana Campino, Julian C. Rayner, Eleanor Drury, Daniel Mead, Upeka Samarakoon, Bronwyn MacInnis, Karen Hayton, Xin-zhuan Su, Michael T. Ferdig, Lisa C. Ranford-Cartwright, Thomas E. Wellems, Alistair Miles, Jonathan M. Mwangi, Gil McVean, Richard D. Pearson, Dominic P. Kwiatkowski, Valentin Ruano Rubio, John O'Brien
The malaria parasite Plasmodium falciparum has a great capacity for evolutionary adaptation to evade host immunity and develop drug resistance. Current understanding of parasite evolution is impeded by the fact that a large fraction of the genome is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f52007a8cb4f36336f0d6da2e911ff
https://doi.org/10.1101/024182
https://doi.org/10.1101/024182
Autor:
Mitchell S. Abrahamsen, Lakshminarayan M. Iyer, Karen Hayton, Cesar Mejia, L. Aravind, Annemarie Bonawitz, Thomas J. Templeton, Gabriele Pradel
Publikováno v:
The Journal of Experimental Medicine
The recent sequencing of several apicomplexan genomes has provided the opportunity to characterize novel antigens essential for the parasite life cycle that might lead to the development of new diagnostic and therapeutic markers. Here we have screene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5abdc8c3647e4d3c87d214a2105ff62b
https://doi.org/10.1084/jem.20031274
https://doi.org/10.1084/jem.20031274
Publikováno v:
Blood. 101:3309-3315
Although selection of hemoglobin C (HbC) by malaria has been speculated for decades, only recently have epidemiologic studies provided support for HbC protection against malaria in West Africa. A reduced risk of malaria associated with the homozygous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d536469da178be3293248dabe8f2af9
https://doi.org/10.1182/blood-2002-10-3105
https://doi.org/10.1182/blood-2002-10-3105
Malaria is the major parasitic disease in tropical developing countries, causing approximately 300 to 500 million febrile illnesses and at least 1.2 million deaths each year. Current antimalarial drugs and mosquito control programs constitute importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a66927b86acce172cae43b555a4e4ee6
https://doi.org/10.1128/9781555817572.ch30
https://doi.org/10.1128/9781555817572.ch30