Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karen Hasty"'
Autor:
Wei Dong, Cheng Tian, Z. Galvin Li, Matthew Bounds, Jiamin Ma, David D. Brand, Xiaoyun Liu, Yanhong Cao, Arielle Beard, Jian Yan, Karen Hasty, John Stuart, Kui Li, Hongsik Cho, Elizabeth A. Fitzpatrick, Linda K. Myers, Yan Jiao, Weikuan Gu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract When IL-1 receptor antagonist (IL-1rn) is knocked out, mice have shown strain background dependent and major QTL regulated susceptibility to spontaneously inflammatory arthritis disease (SAD). The impact on bone properties resulting from the
Externí odkaz:
https://doaj.org/article/a142c5c0a9554584a4639c96315f0450
Autor:
Wei Dong, Cheng Tian, Z. Galvin Li, David Brand, Yanhong Cao, Xiaoyun Liu, Jiamin Ma, Andy Chai, Linda K. Myers, Jian Yan, Karen Hasty, John Stuart, Yan Jiao, Weikuan Gu, Xiaojun Cai
Publikováno v:
Laboratory Animal Research, Vol 39, Iss 1, Pp 1-9 (2023)
Abstract Sex difference has shown in the arthritis diseases in human population and animal models. We investigate how the sex and symmetry vary among mouse models with different genomic backgrounds. Disease data of sex and limbs accumulated in the pa
Externí odkaz:
https://doaj.org/article/2e651b699e3d42939daf63ce8d6455b7
Publikováno v:
Active Learning in Higher Education. 3:117-127
Empowerment of workers has been occurring for a number of years in a high percentage of international business organizations. This shift of decision-making from upper-level management to the workers themselves has created a demand for entry-level emp
Publikováno v:
The Journal of Immunology. 198:127.28-127.28
Toll-like receptor (TLR) signaling has been implicated with the initiation and progression of rheumatoid arthritis (RA). Disruption of TLR signaling at early stages of RA might thereby provide an opportunity to halt the RA progression and ameliorate
Autor:
Ae-Kyung Yi, Tae Won Yoon, Hongsik Cho, David Brand, Young-In Kim-Hoehamer, Jeoung-Eun Park, Karen Hasty, John Stuart
Publikováno v:
The Journal of Immunology. 194:67.5-67.5
Rheumatoid arthritis (RA) may be initiated in part by signaling through Toll-like receptors (TLRs). Disruption of TLR signaling may provide an opportunity to halt the RA process in the earliest stages. We investigated whether protein kinase D1 (PKD1)
Publikováno v:
The Journal of Immunology. 186:110.19-110.19
MDA5 is a pattern recognition receptor responsible for detecting double stranded viral RNA in the cytoplasm. Ligation of MDA5 leads to the induction of inflammatory cytokines and type one interferons (IFN-I) that help coordinate the adaptive and inna
Publikováno v:
The Journal of Immunology. 186:101.9-101.9
Treg cells play an integral role in preventing autoimmunity, and the enhancement of Treg function is an attractive approach for the treatment of autoimmunity. Toward this goal, we have investigated the efficacy and mechanism of action of FTY720 in pr
Publikováno v:
The Journal of Immunology. 184:93.20-93.20
Nucleic-acid sensing molecules provide a first line of defense against microbial infections, but recent studies have shown that their inappropriate activation could promote autoimmunity. MDA-5 senses virally-derived RNA in the cytoplasm, which leads
Publikováno v:
Annals of Biomedical Engineering; Mar2007, Vol. 35 Issue 3, p419-428, 10p
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