Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Karen H. Martin"'
Autor:
Stephanie L. Rellick, Gangqing Hu, Debra Piktel, Karen H. Martin, Werner J. Geldenhuys, Rajesh R. Nair, Laura F. Gibson
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract B-cell acute lymphoblastic leukemia (ALL) is characterized by accumulation of immature hematopoietic cells in the bone marrow, a well-established sanctuary site for leukemic cell survival during treatment. While standard of care treatment re
Externí odkaz:
https://doaj.org/article/02e67ef2e47e4759ada75b05f17cb760
Autor:
Matthew J. Novotny, Dacie R. Bridge, Karen H. Martin, Scott A. Weed, Robert B. Wysolmerski, Joan C. Olson
Publikováno v:
Biology Open, Vol 2, Iss 9, Pp 891-900 (2013)
Summary Cancer patients are known to be highly susceptible to Pseudomonas aeruginosa (Pa) infection, but it remains unknown whether alterations at the tumor cell level can contribute to infection. This study explored how cellular changes associated w
Externí odkaz:
https://doaj.org/article/ec074df46c454e85a8a9632009d0ec68
Autor:
Debbie Piktel, Javohn C. Moore, Sloan Nesbit, Samuel A. Sprowls, Michael D. Craig, Stephanie L. Rellick, Rajesh R. Nair, Ethan Meadows, John M. Hollander, Werner J. Geldenhuys, Karen H. Martin, Laura F. Gibson
Publikováno v:
Cancers
Volume 15
Issue 3
Pages: 707
Volume 15
Issue 3
Pages: 707
B-cell acute lymphoblastic leukemia (ALL) is derived from an accumulation of malignant, immature B cells in the bone marrow and blood. Relapse due, in part, to the emergence of tumor cells that are resistant to front line standard chemotherapy is ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0ecc62a089e43b41acd8a62869cb2e
Autor:
Ethan Meadows, Debbie Piktel, John M. Hollander, Karen H. Martin, Javohn C. Moore, Mark V. Pinti, Laura F. Gibson, Stephanie L. Rellick, Amanda Gatesman Ammer, Werner J. Geldenhuys
Publikováno v:
Free Radic Biol Med
B-cell acute lymphoblastic leukemia (ALL) affects both pediatric and adult patients. Chemotherapy resistant tumor cells that contribute to minimal residual disease (MRD) underlie relapse and poor clinical outcomes in a sub-set of patients. Targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f23382594780182a98bda82df05abaf
https://pubmed.ncbi.nlm.nih.gov/34496224
https://pubmed.ncbi.nlm.nih.gov/34496224
Publikováno v:
J Pharmacol Exp Ther
Disease relapse in B-cell acute lymphoblastic leukemia (ALL), either due to development of acquired resistance after therapy or because of de novo resistance, remains a therapeutic challenge. In the present study, we have developed a cytarabine (Ara-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6f979558125b28b0fbc89af904e3e09
https://doi.org/10.1124/jpet.118.255984
https://doi.org/10.1124/jpet.118.255984
Autor:
Debbie Piktel, Rajesh R. Nair, Stephanie L. Rellick, Werner J. Geldenhuys, Karen H. Martin, Michael D. Craig, Laura F. Gibson
Publikováno v:
Cancers; Volume 14; Issue 11; Pages: 2681
The lack of complete therapeutic success in the treatment of B-cell acute lymphoblastic leukemia (ALL) has been attributed, in part, to a subset of cells within the bone marrow microenvironment that are drug resistant. Recently, the cholesterol synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c293a043cd868c7eda58336c32c37c2
https://doi.org/10.3390/cancers14112681
https://doi.org/10.3390/cancers14112681
Autor:
Stephanie L. Rellick, Karen H. Martin, Debbie Piktel, Patrick Thomas, Quincy A. Hathaway, Laura F. Gibson, John M. Hollander, Pushkar Saralkar, Werner J. Geldenhuys, Rajesh R. Nair
Publikováno v:
Pharm Res
PURPOSE: Pyrvinium pamoate (PP) is an anthelmintic drug that has been found to have anti-cancer activity in several cancer types. In the present study, we evaluated PP for potential anti-leukemic activity in B-cell acute lymphoblastic leukemia (ALL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e44aeae70583fa127dc2a072f6d042
https://doi.org/10.1007/s11095-020-2767-4
https://doi.org/10.1007/s11095-020-2767-4
Autor:
Amanda Gatesman Ammer, Kathleen M. Brundage, James E. Coad, Elena N. Pugacheva, Malcolm D. Mattes, Karen H. Martin, Mackenzie Newman, Gina Sizemore, Sarah L. McLaughlin, Han-Gang Yu
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Background Unlike other breast cancer subtypes that may be treated with a variety of hormonal or targeted therapies, there is a need to identify new, effective targets for triple-negative breast cancer (TNBC). It has recently been recognized that mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ba6f45c2859052362e2d2d650c7a7d
https://pubmed.ncbi.nlm.nih.gov/32586284
https://pubmed.ncbi.nlm.nih.gov/32586284
Autor:
John M. Hollander, Werner J. Geldenhuys, Quincy A. Hathaway, Rajesh R. Nair, Debbie Piktel, Stephanie L. Rellick, Patrick Thomas, Laura F. Gibson, Pushkar Saralkar, Karen H. Martin
Reprogramming of cellular pathways is a crucial mechanism of drug resistance and survival in refractory acute lymphoblastic leukemia (ALL) cells. In the present study, we performed an unbiased gene expression analysis and identified a dysfunctional m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127564e415202405985b1c7924fbdf51
https://doi.org/10.1101/595959
https://doi.org/10.1101/595959
Autor:
Han-Gang Yu, Mackenzie Newman, James E. Coad, Karen H. Martin, Kathleen M. Brundage, Amanda Gatesman Ammer, Sarah L. McLaughlin
Publikováno v:
BMC Cancer
Background Human triple-negative breast cancer has limited therapeutic choices. Breast tumor cells have depolarized plasma membrane potential. Using this unique electrical property, we aim to develop an effective selective killing of triple-negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34f765f8f37b97be85e409bab821dc70
https://doi.org/10.1186/s12885-017-3168-x
https://doi.org/10.1186/s12885-017-3168-x