Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Karen H. Hales"'
Publikováno v:
Metabolites, Vol 13, Iss 8, p 945 (2023)
This article illustrates how dietary flaxseed can be used to reduce cancer risk, specifically by attenuating obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD). We utilize a targeted metabolomics dataset in combination with a rea
Externí odkaz:
https://doaj.org/article/47211d01c22c4cae85ff192e28f3fc9f
Publikováno v:
Molecules, Vol 26, Iss 18, p 5674 (2021)
We used an LC-MS/MS metabolomics approach to investigate one-carbon metabolism in the plasma of flaxseed-fed White Leghorn laying hens (aged 3.5 years). In our study, dietary flaxseed (via the activity of a vitamin B6 antagonist known as “1-amino d
Externí odkaz:
https://doaj.org/article/ec081b0a182243139dc66452c8f82064
Publikováno v:
Molecules
Volume 26
Issue 18
Molecules, Vol 26, Iss 5674, p 5674 (2021)
Volume 26
Issue 18
Molecules, Vol 26, Iss 5674, p 5674 (2021)
We used an LC-MS/MS metabolomics approach to investigate one-carbon metabolism in the plasma of flaxseed-fed White Leghorn laying hens (aged 3.5 years). In our study, dietary flaxseed (via the activity of a vitamin B6 antagonist known as “1-amino d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2df2261bbf80e6ecd6ccd88ed9144b9b
OBJECTIVES: In 2012, ovarian cancer accounted for 239,000 new cancer cases and 152,000 cancer-related deaths worldwide. Epidemiological studies around the world suggest that high dietary consumption of polyunsaturated fatty acids (PUFAs) reduces a wo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b122f078878cd37679a91c16272adbe
https://europepmc.org/articles/PMC6576081/
https://europepmc.org/articles/PMC6576081/
Autor:
Erfan Eilati, Rui Yu, Karen H. Hales, Dale B. Hales, Richard B. van Breemen, Kristine Fricano, Yan Zhuge
Publikováno v:
Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 89(4):179-187
Prevention of ovarian cancer is the best approach for reducing the impact of this deadly disease. The laying hen is a robust model of spontaneous ovarian cancer that recapitulates the human disease. Dietary intervention with flaxseed, the richest veg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126c90f4e06e35c69921f2b54b2298d4
Autor:
Tristan Shankara, Dale B. Hales, Thorsten Diemer, Karen H. Hales, John A. Allen, Steve Buck, Paul Janus
Publikováno v:
Endocrinology. 147:3924-3935
The first and rate-limiting step in the biosynthesis of steroid hormones is the transfer of cholesterol into mitochondria, which is facilitated by the steroidogenic acute regulatory (StAR) protein. Recent study of Leydig cell function has focused on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a719e13743576e0a8a93015fe915fff
https://doi.org/10.1210/en.2005-1204
https://doi.org/10.1210/en.2005-1204
Publikováno v:
Endocrine. 25:265-276
Chronic inflammatory disease and acute infection are well known to inhibit gonadal steroidogenesis. Previous studies have demonstrated that immune activation in response to lipopolysaccharide (LPS) results in reductions in serum testosterone, and thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f000613cbfaf501e739703259a99a841
https://doi.org/10.1385/endo:25:3:265
https://doi.org/10.1385/endo:25:3:265
Autor:
Sarah Eimerl, Zvi Granot, Naomi Melamed-Book, Eran Silverman, Karen H. Hales, Dale B. Hales, Rina Timberg, Ruth Friedlander, Joseph Orly, Douglas M. Stocco
Publikováno v:
Endocrine Research. 28:375-386
The Steroidogenic Acute Regulatory (StAR) protein is a mitochondrial protein required for the transport of cholesterol substrate to the P450scc enzyme located in the inner mitochondrial membranes of steroid producing cells. This study suggests that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4e0a01d533442f8796013cc8460e0e
https://doi.org/10.1081/erc-120016812
https://doi.org/10.1081/erc-120016812
Publikováno v:
Journal of Biological Chemistry. 276:46583-46596
The metabolism of cholesterol by cytochrome P450 side chain cleavage enzyme is hormonally regulated in steroidogenic tissues via intramitochondrial cholesterol transport. The mediating steroidogenic acute regulatory protein (StAR) is synthesized as a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90042e737742ea8425c0022f949ff8e4
https://doi.org/10.1074/jbc.m107815200
https://doi.org/10.1074/jbc.m107815200
Publikováno v:
Biology of Reproduction. 61:643-650
With interest in steroidogenic acute regulatory protein (StAR) involvement in the luteolytic process, we studied changes in serum progesterone levels and the concomitant expression of StAR mRNA and protein (37-, 32-, and 30-kDa forms) in postovulator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf1dacd745d9cd7f7872177a7770b31c
https://doi.org/10.1095/biolreprod61.3.643
https://doi.org/10.1095/biolreprod61.3.643