DlgS97/SAP97, a neuronal isoform of discs large, regulates ethanol tolerance.

Autor: Rajani Maiya, Seonok Lee, Karen H Berger, Eric C Kong, Justin B Slawson, Leslie C Griffith, Kogo Takamiya, Richard L Huganir, Ben Margolis, Ulrike Heberlein

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e48967 (2012)

From a genetic screen for Drosophila melanogaster mutants with altered ethanol tolerance, we identified intolerant (intol), a novel allele of discs large 1 (dlg1). Dlg1 encodes Discs Large 1, a MAGUK (Membrane Associated Guanylate Kinase) family memb

Externí odkaz: https://doaj.org/article/f48803c03cd94b598bbfc915c6fb7e48

Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption

Autor: Michiel L. Bots, Georgy Bakalkin, Claire Troakes, Gérard Waeber, Anna-Liisa Hartikainen, Danielle M. Dick, Kay-Tee Khaw, Stéphane Cauchi, Toni-Kim Clarke, Jian'an Luan, Jaakko Kaprio, Charlotte Onland-Moret, Yurii S. Aulchenko, Wolfgang H. Sommer, Ben A. Oostra, Alberto Fernández-Medarde, Jouke-Jan Hottenga, Kari Stefansson, Angela Doering, Lachlan J. M. Coin, Kijoung Song, Ida Surakk, Sylvane Desrivières, Pimphen Charoen, Nicholas G. Martin, Jacqueline C.M. Witteman, John C. Chambers, Tim D. Spector, Stéphane Lobbens, Guangju Zhai, Peter Vollenweider, David Stacey, Anbarasu Lourdusamy, Ulrike Heberlein, Victor Hesselbrock, Leena Peltonen, James Scott, Miklós Palkovits, Albert Hofman, Xin Yuan, Cornelia M. van Duijn, Gunter Schumann, Yvonne T. van der Schouw, Nicole Vogelzangs, Nicole Soranzo, Paul Elliott, Brenda W.J.H. Penninx, Nicholas J. Wareham, Eugenio Santos, Silvia Polidoro, Diederick E. Grobbee, Norbert Dahmen, Daniel F. Gudbjartsson, Dorret I. Boomsma, Rainer Spanagel, Oliver Staehlin, Anke Tönjes, Matthieu Maroteaux, Ainhoa Bilbao, Eco J. C. de Geus, Francesca Ducci, Vincent Mooser, Mark I. McCarthy, Paolo Vineis, Christine Cavalcanti-Proença, Weihua Zhang, Nelson B. Freimer, Ruth J. F. Loos, Andres Metspalu, Tatiana Foroud, Rudolf A. de Boer, Thorarinn Tyrfingsson, Anneli Pouta, Beverley Balkau, Matti Isohanni, Paul F. O'Reilly, Massimo Mangino, Stephan J. L. Bakker, Elemi J. Breetvelt, Marjo-Riitta Järvelin, Tõnu Esko, Inga Prokopenko, Delphine Beury, Erich Wichmann, Gerjan Navis, Jaana Laitinen, John Whitfield, Karen H. Berger, Thorgeir E. Thorgeirsson, Alanna C. Easton, Brigitte Kuehnel, Ulla Sovio, Cuno S.P.M. Uiterwaal, Unnur Thorsteinsdottir, Fazil Aliev, Najaf Amin, Dale R. Nyholt, Alejandro Núñez, Dawn M. Waterworth, Mattijs E. Numans, Pim van der Harst, Michael Stumvoll, Howard J. Edenberg, Johannes H. Smit, Gonneke Willemsen, Andrew C. Heath, Simonetta Guarrera, Fulvio Ricceri, Joline W.J. Beulens, Giuseppe Matullo, Anokhi Ali Khan, Jean-Antoine Girault, Christian Mueller, Jaspal S. Kooner, André G. Uitterlinden, Jing Hua Zhao

Publikováno v: Proceedings of the National Academy of Sciences, 108(17), 7119-7124
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 108(17), 7119-7124. NATL ACAD SCIENCES
Proceedings of the National Academy of Sciences of the U.S.A., 108(17), 7119-7124. National Academy of Sciences
Schumann, G, Coin, L J M, Lourdusamy, A, Charoen, P, Berger, K H, Stacey, D, Desrivières, S, Aliev, F A, Khan, A A, Amin, N, Aulchenko, Y S, Bakalkin, G, Bakker, S J, Balkau, B, Beulens, J W, Bilbao, A, de Boer, R A, Beury, D, Bots, M L, Breetvelt, E J, Cauchi, S, Cavalcanti-Proença, C, Chambers, J C, Clarke, T K, Dahmen, N, de Geus, E J C, Dick, D, Duccia, F, Easton, A, Edenberg, H J, Esk, T, Fernández-Medarde, A, Foroud, T, Freimer, N B, Girault, J A, Grobbee, D E, Guarreray, S, Gudbjartsson, D F, Hartikainen, A-L, Heath, A C, Hesselbrock, V, Hofman, A, Hottenga, J J, Isohanni, M, Kaprio, J, Khaw, K T, Kuehnel, B, Laitinen, J, Lobbens, S, Luan, J, Mangino, M, Maroteau, M, Oostra, B A, O’Reilly, P F, Penninx, B W J H, Pouta, A, Prokopenko, I, Ricceri, F, Santos, E, Smit, J H, Soranzo, N, Stumvoll, M, Surakka, I, Thorgeirsson, T E, Thorsteinsdottir, U, Troakes, C, Tyrfingsson, T, Tönjes, A, Uiterwaal, C S, Uitterlinden, A G, van der Harst, P, van der Schouw, Y T, Staehlin, O, Vogelzangs, N, Vollenweider, P, Waeber, G, Wareham, N J, Waterworth, D, Whitfield, J B, Wichmann, H E, Willemsen, G, Witteman, J C, Martin, N G, Metspalu, A, Scott, J, Spector, T D, Loos, R J, Boomsma, D I, Mooser, V, Peltonen, L, Stefansson, K, van Duijn, C M, Vineis, P, Sommer, W H, Kooner, J S, Spanagel, R, Heberlein, U A, Numans, M E, Jarvelin, M-R & Elliott, P 2011, ' Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption ', Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 17, pp. 7119-7124 . https://doi.org/10.1073/pnas.1017288108
Proceedings of the National Academy of Sciences of the United States of America, vol. 108, no. 17, pp. 7119-7124
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 108(17), 7119-7124. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 108(17), 7119-7124. National Acad Sciences

Alcohol consumption is a moderately heritable trait, but the genetic basis in humans is largely unknown, despite its clinical and societal importance. We report a genome-wide association study meta-analysis of ∼2.5 million directly genotyped or imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::226a59d12e172033352f2534cacdc663
https://doi.org/10.1073/pnas.1017288108

Happyhour, a Ste20 Family Kinase, Implicates EGFR Signaling in Ethanol-Induced Behaviors

Autor: Ulrike Heberlein, Ammon B. Corl, Jeffrey A. Simms, Galit Ophir-Shohat, Julie Gesch, Selena E. Bartlett, Karen H. Berger

Publikováno v: Cell

SummaryThe consequences of alcohol use disorders (AUDs) are devastating to individuals and society, yet few treatments are currently available. To identify genes regulating the behavioral effects of ethanol, we conducted a genetic screen in Drosophil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50fdc266ad68e9482d611ed2ed1b6b37

Legionella pneumophilaDotA protein is required for early phagosome trafficking decisions that occur within minutes of bacterial uptake

Autor: Craig R. Roy, Karen H. Berger, Ralph R. Isberg

Publikováno v: Molecular Microbiology. 28:663-674

Numerous intracellular bacterial pathogens modulate the nature of the membrane-bound compartment in which they reside, although little is known about the molecular basis for this control. Legionella pneumophila is a bacterial pathogen able to grow wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad821949fd944d88f47de49e3d2f530
https://doi.org/10.1046/j.1365-2958.1998.00841.x

Mitochondrial distribution and inheritance

Autor: Michael P. Yaffe, Karen H. Berger

Publikováno v: Experientia. 52:1111-1116

Mechanisms mediating the inheritance of mitochondria are poorly understood, but recent studies with the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have begun to identify components that facilitate this essential process. These comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74f02e3921c204aea316e6afa7ceae2
https://doi.org/10.1007/bf01952109