Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation

Autor: Judith M.E.M. Cosemans, Matthew T. Harper, Johan W. M. Heemskerk, Karen Gilio, Alastair W. Poole, Kellie J. Hall

Publikováno v: PLoS ONE
PLoS ONE, Vol 3, Iss 9, p e3277 (2008)

BACKGROUND: PKCtheta is a novel protein kinase C isozyme, predominately expressed in T cells and platelets. PKCtheta(-/-) T cells exhibit reduced activation and PKCtheta(-/-) mice are resistant to autoimmune disease, making PKCtheta an attractive the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c0816b62cd637f333d1eaaef3e6ee83

Functional Divergence of Platelet Protein Kinase C (PKC) Isoforms in Thrombus Formation on Collagen

Autor: Imke C. A. Munnix, Karen Gilio, Johan W. M. Heemskerk, Alastair W. Poole, Michael Leitges, Lenneke Prinzen, Jeffery D. Molkentin, Matthew T. Harper, Olga Konopatskaya, Judith M.E.M. Cosemans, Qinghang Liu

Publikováno v: The Journal of Biological Chemistry
Journal of Biological Chemistry, 285(30), 23408-23417. American Society for Biochemistry and Molecular Biology, Inc.

Arterial thrombosis, a major cause of myocardial infarction and stroke, is initiated by activation of blood platelets by subendothelial collagen. The protein kinase C (PKC) family centrally regulates platelet activation, and it is becoming clear that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8ae02971e768105958b70048517fb2c
https://cris.maastrichtuniversity.nl/en/publications/552c65f6-6087-44a1-a378-8e2edef9feb2

Collagen‐mimetic peptides mediate flow‐dependent thrombus formation by high‐ or low‐affinity binding of integrin α2β1 and glycoprotein VI

Autor: Karen Gilio, Tilman M. Hackeng, Hans Deckmyn, Marion A.H. Feijge, Nicolas Raynal, P A Smethurst, Imke C. A. Munnix, Richard W. Farndale, Johan W. M. Heemskerk, Pia Siljander

Publikováno v: Journal of Thrombosis and Haemostasis. 6:2132-2142

Summary. Background: Collagen acts as a potent surface for platelet adhesion and thrombus formation under conditions of blood flow. Studies using collagen-derived triple-helical peptides have identified the GXX’GER motif as an adhesive ligand for p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502f6e8073fcaf96c4990c8c84adb22b
https://doi.org/10.1111/j.1538-7836.2008.03167.x

Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation*

Autor: Magdalena Chrzanowska-Wodnicka, Judith M.E.M. Cosemans, Marion A.H. Feijge, Stewart O. Sage, Shigeo Koyasu, Rivka Lillian, Johan W. M. Heemskerk, Simone M. Schoenwaelder, Karen Gilio, Pierre Mangin, Servé Olieslagers, Imke C. A. Munnix, Paola E. J. van der Meijden, Shaun P. Jackson

Platelets are activated by adhesion to vascular collagen via the immunoglobulin receptor, glycoprotein VI (GPVI). This causes potent signaling toward activation of phospholipase Cgamma2, which bears similarity to the signaling pathway evoked by T- an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9d5b4f155321de9b15f59a4e68023f
https://europepmc.org/articles/PMC2797144/

PKCalpha regulates platelet granule secretion and thrombus formation in mice

Autor: Sidney W. Whiteheart, Karen Gilio, Johan W. M. Heemskerk, Alastair W. Poole, Judith M.E.M. Cosemans, Yan Zhao, Paul Verkade, Zubair A. Karim, Jeffery D. Molkentin, Matthew T. Harper, Olga Konopatskaya, Steve P. Watson

Publikováno v: The Journal of clinical investigation. 119(2)

Platelets are central players in atherothrombosis development in coronary artery disease. The PKC family provides important intracellular mechanisms for regulating platelet activity, and platelets express several members of this family, including the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0be64c30d079a1358237ad39b536c24
https://pubmed.ncbi.nlm.nih.gov/19147982