Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Karen Ghauharali-van der Vlugt"'
Autor:
Jason M R Gill, Carlos Celis-Morales, Mirthe Muilwijk, Irene G M van Valkengoed, Frédéric M Vaz, Susan M I Goorden, Michel H Hof, Karen Ghauharali-van der Vlugt, Femke S Beers-Stet
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
Introduction People of South Asian origin are at high risk of type 2 diabetes (T2D), but the underpinning mechanisms are not fully understood. We determined ethnic differences in acylcarnitine, amino acid and sphingolipid concentrations and determine
Externí odkaz:
https://doaj.org/article/f8c49b90a75841f9a8c6429f5ab29b0e
Autor:
AndréR.A. Marques, Mina Mirzaian, Hisako Akiyama, Patrick Wisse, Maria J. Ferraz, Paulo Gaspar, Karen Ghauharali-van der Vlugt, Rianne Meijer, Pilar Giraldo, Pilar Alfonso, Pilar Irún, Maria Dahl, Stefan Karlsson, Elena V. Pavlova, Timothy M. Cox, Saskia Scheij, Marri Verhoek, Roelof Ottenhoff, CindyP.A.A. van Roomen, Navraj S. Pannu, Marco van Eijk, Nick Dekker, Rolf G. Boot, Herman S. Overkleeft, Edward Blommaart, Yoshio Hirabayashi, Johannes M. Aerts
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 3, Pp 451-463 (2016)
The membrane lipid glucosylceramide (GlcCer) is continuously formed and degraded. Cells express two GlcCer-degrading β-glucosidases, glucocerebrosidase (GBA) and GBA2, located in and outside the lysosome, respectively. Here we demonstrate that throu
Externí odkaz:
https://doaj.org/article/57f08df9b338494281ce0b82ea7d752a
Autor:
Marco van Eijk, Jan Aten, Nora Bijl, Roelof Ottenhoff, Cindy P A A van Roomen, Peter F Dubbelhuis, Ingar Seeman, Karen Ghauharali-van der Vlugt, Hermen S Overkleeft, Cynthia Arbeeny, Albert K Groen, Johannes M F G Aerts
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4723 (2009)
Adipose tissue is a critical mediator in obesity-induced insulin resistance. Previously we have demonstrated that pharmacological lowering of glycosphingolipids and subsequently GM3 by using the iminosugar AMP-DNM, strikingly improves glycemic contro
Externí odkaz:
https://doaj.org/article/4de7292dc62c4bccba10a1b9b8fc6b87
Autor:
Anna Andersson, Anna Cäcilia Ingham, Sofie Edslev, Julie B. K. Sølberg, Lone Skov, A. Koch, Karen Ghauharali-van der Vlugt JM, Femke Stet S, Marie-Charlotte Brüggen, Ivone Jakasa, Sanja Kezic, Jacob Thyssen
Background: Atopic dermatitis (AD) endotypes differ with ethnicity. We examined the skin microbiota, cytokine-, and lipid-profiles in Greenlandic Inuit and Danish children with AD. Methods: 25 Inuit children with AD and 25 Inuit control children were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d0cfc395833ae1e6f9a8d1c15b58c6d
https://doi.org/10.22541/au.167715638.86180804/v1
https://doi.org/10.22541/au.167715638.86180804/v1
Autor:
Sanja Kezic, Maeve A. McAleer, Ivone Jakasa, Susan M.I. Goorden, Karen Ghauharali‐van der Vlugt, Femke S. Beers‐Stet, Judith Meijer, Jeroen Roelofsen, Monique M. Nieman, André B.P. van Kuilenburg, Alan D. Irvine
Publikováno v:
British journal of dermatology, 186(6), 988-996. Wiley-Blackwell
Background: Atopic dermatitis (AD) is characterized by immune dysregulations and an impaired skin barrier, including abnormalities in lipid organization. In the stratum corneum (SC), β-glucocerebrosidase (GBA) mediates transformation of glucosylcera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdce4c26db20388f3627290fe6472ba2
https://pure.amc.nl/en/publications/children-with-atopic-dermatitis-show-increased-activity-of-glucocerebrosidase-and-stratum-corneum-levels-of-glucosylcholesterol-that-are-strongly-related-to-the-local-cytokine-milieu(08fb36be-8893-4458-a5a1-cc09b2f0fd5f).html
https://pure.amc.nl/en/publications/children-with-atopic-dermatitis-show-increased-activity-of-glucocerebrosidase-and-stratum-corneum-levels-of-glucosylcholesterol-that-are-strongly-related-to-the-local-cytokine-milieu(08fb36be-8893-4458-a5a1-cc09b2f0fd5f).html
Autor:
Karen Ghauharali-van der Vlugt, Jason M.R. Gill, Susan M. I. Goorden, Frédéric M. Vaz, Carlos Celis-Morales, Mirthe Muilwijk, Irene G. M. van Valkengoed, Femke S Beers-Stet, Michel H. Hof
Publikováno v:
BMJ open diabetes research & care, 8(1). BMJ Publishing Group
BMJ open diabetes research & care, 8(1)
BMJ Open Diabetes Research & Care
Muilwijk, M, Goorden, S M I, Celis-Morales, C, Hof, M H, Ghauharali-van der Vlugt, K, Beers-Stet, F S, Gill, J M R, Vaz, F M & van Valkengoed, I G M 2020, ' Contributions of amino acid, acylcarnitine and sphingolipid profiles to type 2 diabetes risk among South-Asian Surinamese and Dutch adults ', BMJ open diabetes research & care, vol. 8, no. 1 . https://doi.org/10.1136/bmjdrc-2019-001003
BMJ open diabetes research & care, 8(1)
BMJ Open Diabetes Research & Care
Muilwijk, M, Goorden, S M I, Celis-Morales, C, Hof, M H, Ghauharali-van der Vlugt, K, Beers-Stet, F S, Gill, J M R, Vaz, F M & van Valkengoed, I G M 2020, ' Contributions of amino acid, acylcarnitine and sphingolipid profiles to type 2 diabetes risk among South-Asian Surinamese and Dutch adults ', BMJ open diabetes research & care, vol. 8, no. 1 . https://doi.org/10.1136/bmjdrc-2019-001003
IntroductionPeople of South Asian origin are at high risk of type 2 diabetes (T2D), but the underpinning mechanisms are not fully understood. We determined ethnic differences in acylcarnitine, amino acid and sphingolipid concentrations and determined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2ed4457d41bcae30b4a2ecf94f1f25
https://pure.amc.nl/en/publications/contributions-of-amino-acid-acylcarnitine-and-sphingolipid-profiles-to-type-2-diabetes-risk-among-southasian-surinamese-and-dutch-adults(27ac016d-f83f-4c7a-b771-0b0292e223bd).html
https://pure.amc.nl/en/publications/contributions-of-amino-acid-acylcarnitine-and-sphingolipid-profiles-to-type-2-diabetes-risk-among-southasian-surinamese-and-dutch-adults(27ac016d-f83f-4c7a-b771-0b0292e223bd).html
Autor:
Johannes M. F. G. Aerts, Anton P. Bussink, Jocelyne Vreede, Wilma E. Donker-Koopman, Marri Verhoek, Carla E. M. Hollak, Karen Ghauharali-van der Vlugt, Rolf G. Boot, Richard R. Sprenger
Publikováno v:
FEBS Journal. 276:5678-5688
Chitotriosidase (CHIT1) is a chitinase that is secreted by activated macrophages. Plasma chitotriosidase activity reflects the presence of lipid-laden macrophages in patients with Gaucher disease. CHIT1 activity can be conveniently measured using flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1501ff514bbb263461c8c874783aa001
https://doi.org/10.1111/j.1742-4658.2009.07259.x
https://doi.org/10.1111/j.1742-4658.2009.07259.x
Autor:
Aldi Poppema, Johanna E. M. Groener, Mirjam Langeveld, Karen Ghauharali-van der Vlugt, Sijmen Kuiper, Carla E. M. Hollak, Johannes M. F. G. Aerts
Publikováno v:
Clinica chimica acta; international journal of clinical chemistry, 389(1-2), 109-113. Elsevier
BACKGROUND: Patients with Gaucher disease show signs of insulin resistance. The ganglioside GM3 has recently shown to be a negative regulator of insulin sensitivity. In fibroblasts of Gaucher patients, deficient in degradation of glucosylceramide, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7be7025322dda8a2cbde1b6b67eb471
https://doi.org/10.1016/j.cca.2007.12.001
https://doi.org/10.1016/j.cca.2007.12.001
Autor:
Rolf G. Boot, Karen Ghauharali-van der Vlugt, Anton P. Bussink, Johanna E. M. Groener, Johannes M. F. G. Aerts
Publikováno v:
Analytical biochemistry, 384(1), 191-193. Academic Press Inc.
ResearcherID
ResearcherID
Chitinases are hydrolases capable of hydrolyzing the abundant natural polysaccharide chitin. Next to artificial fluorescent substrates, more physiological chito-oligomers are commonly used in chitinase assays. Analysis of chito-oligosaccharides produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd54a2e15912862ba9f0b96da81cad76
https://doi.org/10.1016/j.ab.2008.09.028
https://doi.org/10.1016/j.ab.2008.09.028
Autor:
Anton P, Bussink, Marri, Verhoek, Jocelyne, Vreede, Karen, Ghauharali-van der Vlugt, Wilma E, Donker-Koopman, Richard R, Sprenger, Carla E, Hollak, Johannes M F G, Aerts, Rolf G, Boot
Publikováno v:
The FEBS journal. 276(19)
Chitotriosidase (CHIT1) is a chitinase that is secreted by activated macrophages. Plasma chitotriosidase activity reflects the presence of lipid-laden macrophages in patients with Gaucher disease. CHIT1 activity can be conveniently measured using flu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2d4a2deaad8ea1247a2ba2426779618d
https://pubmed.ncbi.nlm.nih.gov/19725875
https://pubmed.ncbi.nlm.nih.gov/19725875