Prescribing for change – safer antimicrobial use in hospitals

Autor: Sean O'Gorman, Arthur Jackson, Karen Fitzmaurice

Publikováno v: Clinical Medicine, Vol 24, Iss 6, Pp 100261- (2024)

The World Health Organization (WHO) has stated that antimicrobial resistance is one of the greatest health threats facing humanity and is responsible for significant morbidity and mortality, with a disproportionate impact on vulnerable groups of pati

Externí odkaz: https://doaj.org/article/f58063517b2e456bbd6ec89522bf0506

What are the critical steps in processing blood cultures? A prospective audit evaluating current practice of reporting blood cultures in a centralised laboratory serving secondary care hospitals

Autor: Jayakeerthi Rangaiah, Reela Varghese, David Garner, Manjula Meda, Farnaz Dashti, Clive Grundy, E Hutley, James Clayton, Katherine Groves, Karen Fitzmaurice

Publikováno v: Journal of Clinical Pathology. 70:361-366

AimsTo assess current procedures of processing positive blood cultures against national standards with an aim to evaluate its clinical impact and to determine the utility of currently available rapid identification and susceptibility tests in process

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0531c1372b29a9f0532dd3c3acafdd50
https://doi.org/10.1136/jclinpath-2016-204091

Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome

Autor: Spyros A. Kalams, M. Azim Ansari, Simon Mallal, Andri Rauch, E Barnes, Louise Barnett, Ian James, Anne Plauzolles, Mark A. Pilkinton, Karen Fitzmaurice, Mina John, Elouise Gaylard, Heidi E. Drummer, Silvana Gaudieri, Pooja Deshpande, Dermot Kelleher, Katja Pfafferott, Andrew Lucas, Michaela Lucas, Wyatt J. McDonnell, Cody A. Chastain, Shahzma Merani, Vincent Pedergnana, Paul Klenerman, Amy Prosser

Publikováno v: Scientific Reports
Lucas, Michaela; Deshpande, Pooja; James, Ian; Rauch, Andri; Pfafferott, Katja; Gaylard, Elouise; Merani, Shahzma; Plauzolles, Anne; Lucas, Andrew; McDonnell, Wyatt; Kalams, Spyros; Pilkinton, Mark; Chastain, Cody; Barnett, Louise; Prosser, Amy; Mallal, Simon; Fitzmaurice, Karen; Drummer, Heidi; Ansari, M. Azim; Pedergnana, Vincent; ... (2018). Evidence of CD4+ T cell-mediated immune pressure on the Hepatitis C virus genome. Scientific Reports, 8(1), p. 7224. Nature Publishing Group 10.1038/s41598-018-25559-6
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, 2018, 8 (1), pp.7224. ⟨10.1038/s41598-018-25559-6⟩

Hepatitis C virus (HCV)-specific T cell responses are critical for immune control of infection. Viral adaptation to these responses, via mutations within regions of the virus targeted by CD8+ T cells, is associated with viral persistence. However, id

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cacc2dfd3caf5077e3d86ba2c04ea74d
http://europepmc.org/articles/PMC5940905

Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection

Autor: Suzanne Norris, Stuart Sims, Elizabeth Freitas, Shazma Merani, Eugene M. Dempsey, Susan McKiernan, Narayan Ramamurthy, Karen Fitzmaurice, Ruth Simmons, Silvana Gaudieri, Dermot Kelleher, Danijela Petrovic, Paul Klenerman, Aideen Long, Susan M. Lea

Publikováno v: Gut

Background and aims: CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association be

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fbc9255e9936ce6d5f45860a1ce0e16
http://europepmc.org/articles/PMC3184218

Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection

Autor: Karen, Fitzmaurice, Jacob, Hurst, Megan, Dring, Andri, Rauch, Paul J, McLaren, Huldrych F, Günthard, Clair, Gardiner, Paul, Klenerman, S, Yerly

Publikováno v: Fitzmaurice, Karen; Hurst, Jacob; Dring, Megan; Rauch, Andri; McLaren, Paul J.; Günthard, Huldrych F.; Gardiner, Clair; Klenerman, Paul (2015). Additive effects of HLA alleles and innate immune genes determine viral outcome in HCV infection. Gut, 64(5), pp. 813-819. BMJ Publishing Group 10.1136/gutjnl-2013-306287
Gut, vol. 64, no. 5, pp. 813-819
Gut

BACKGROUND: Chronic HCV infection is a leading cause of liver-related morbidity globally. The innate and adaptive immune responses are thought to be important in determining viral outcomes. Polymorphisms associated with the IFNL3 (IL28B) gene are str

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::177457f2bfa4ca659716d56773dfd8c9
http://ora.ox.ac.uk/objects/uuid:ed57bf67-36e4-483c-90ab-33913485f021