Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Karen F, Berman"'
Autor:
Madeline H. Garvey, Tiffany Nash, J. Shane Kippenhan, Philip Kohn, Carolyn B. Mervis, Daniel P. Eisenberg, Jean Ye, Michael D. Gregory, Karen F. Berman
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Understanding neurogenetic mechanisms underlying neuropsychiatric disorders such as schizophrenia and autism is complicated by their inherent clinical and genetic heterogeneity. Williams syndrome (WS), a rare neurodevelopmental condition in
Externí odkaz:
https://doaj.org/article/c13498acbf25494da707b14cb8b122fd
Autor:
Leonardo Sportelli, Daniel P. Eisenberg, Roberta Passiatore, Enrico D’Ambrosio, Linda A. Antonucci, Jasmine S. Bettina, Qiang Chen, Aaron L. Goldman, Michael D. Gregory, Kira Griffiths, Thomas M. Hyde, Joel E. Kleinman, Antonio F. Pardiñas, Madhur Parihar, Teresa Popolizio, Antonio Rampino, Joo Heon Shin, Mattia Veronese, William S. Ulrich, Caroline F. Zink, Alessandro Bertolino, Oliver D. Howes, Karen F. Berman, Daniel R. Weinberger, Giulio Pergola
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract The polygenic architecture of schizophrenia implicates several molecular pathways involved in synaptic function. However, it is unclear how polygenic risk funnels through these pathways to translate into syndromic illness. Using tensor decom
Externí odkaz:
https://doaj.org/article/bdf3671448254ff98814912fb8b64f61
Autor:
Shau-Ming Wei, Michael D. Gregory, Tiffany Nash, Andrea de Abreu e Gouvêa, Carolyn B. Mervis, Katherine M. Cole, Madeline H. Garvey, J. Shane Kippenhan, Daniel P. Eisenberg, Bhaskar Kolachana, Peter J. Schmidt, Karen F. Berman
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109113- (2024)
Summary: Pubertal timing, including age at menarche (AAM), is a heritable trait linked to lifetime health outcomes. Here, we investigate genetic mechanisms underlying AAM by combining genome-wide association study (GWAS) data with investigations of t
Externí odkaz:
https://doaj.org/article/5dfc18eed7bb45aeb146d7a4022ab560
Autor:
Angela M. Ianni, Daniel P. Eisenberg, Erie D. Boorman, Sara M. Constantino, Catherine E. Hegarty, Michael D. Gregory, Joseph C. Masdeu, Philip D. Kohn, Timothy E. Behrens, Karen F. Berman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Foraging behavior requires weighing costs of time to decide when to leave one reward patch to search for another. Computational and animal studies suggest that striatal dopamine is key to this process; however, the specific role of dopamine
Externí odkaz:
https://doaj.org/article/8b16c463319b429da899f1c251095ffb
Autor:
J. Shane Kippenhan, Michael D. Gregory, Tiffany Nash, Philip Kohn, Carolyn B. Mervis, Daniel P. Eisenberg, Madeline H. Garvey, Katherine Roe, Colleen A. Morris, Bhaskar Kolachana, Ariel M. Pani, Leah Sorcher, Karen F. Berman
Publikováno v:
Journal of Neurodevelopmental Disorders, Vol 15, Iss 1, Pp 1-13 (2023)
Abstract Background Williams syndrome (WS), a rare neurodevelopmental disorder caused by hemizygous deletion of ~ 25 genes from chromosomal band 7q11.23, affords an exceptional opportunity to study associations between a well-delineated genetic abnor
Externí odkaz:
https://doaj.org/article/3c215d21ffc540c18549592b98b88ec2
Autor:
Olanrewaju A. Ogunleye, Harish Raviprakash, Ashlee M. Simmons, Rhasaan T.M. Bovell, Pedro E. Martinez, Jack A. Yanovski, Karen F. Berman, Peter J. Schmidt, Elizabeth C. Jones, Hadi Bagheri, Nadia M. Biassou, Li-Yueh Hsu
Publikováno v:
Tomography, Vol 9, Iss 1, Pp 139-149 (2023)
Background: The development of adipose tissue during adolescence may provide valuable insights into obesity-associated diseases. We propose an automated convolutional neural network (CNN) approach using Dixon-based magnetic resonance imaging (MRI) to
Externí odkaz:
https://doaj.org/article/816eee209bf045f58103607194eec338
Autor:
Shau-Ming Wei, Erica B. Baller, Pedro E. Martinez, Allison C. Goff, Howard J. Li, Philip D. Kohn, J. Shane Kippenhan, Steven J. Soldin, David R. Rubinow, David Goldman, Peter J. Schmidt, Karen F. Berman
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Substantial evidence suggests that circulating ovarian steroids modulate behavior differently in women with PMDD than in those without this condition. However, hormonal state-related abnormalities of neural functioning in PMDD remain to be b
Externí odkaz:
https://doaj.org/article/d6239705833b4e6d9e2b52e67061ff3c
Autor:
Rachael K. Blackman, Dwight Dickinson, Daniel P. Eisenberg, Michael D. Gregory, José A. Apud, Karen F. Berman
Publikováno v:
Schizophrenia Research: Cognition, Vol 27, Iss , Pp 100223- (2022)
Cognitive symptoms of schizophrenia are reported to be minimally responsive to treatment with antipsychotic medications, though variability exists and many prior studies have significant confounds. Here, we examined the response of cognitive symptoms
Externí odkaz:
https://doaj.org/article/b0736ae187b74af2aecddd7097b75af4
Autor:
Emily E. Burke, Joshua G. Chenoweth, Joo Heon Shin, Leonardo Collado-Torres, Suel-Kee Kim, Nicola Micali, Yanhong Wang, Carlo Colantuoni, Richard E. Straub, Daniel J. Hoeppner, Huei-Ying Chen, Alana Sellers, Kamel Shibbani, Gregory R. Hamersky, Marcelo Diaz Bustamante, BaDoi N. Phan, William S. Ulrich, Cristian Valencia, Amritha Jaishankar, Amanda J. Price, Anandita Rajpurohit, Stephen A. Semick, Roland W. Bürli, James C. Barrow, Daniel J. Hiler, Stephanie C. Page, Keri Martinowich, Thomas M. Hyde, Joel E. Kleinman, Karen F. Berman, Jose A. Apud, Alan J. Cross, Nicholas J. Brandon, Daniel R. Weinberger, Brady J. Maher, Ronald D. G. McKay, Andrew E. Jaffe
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Here, authors present results of a hiPSC transcriptomics study on corticogenesis from multiple donors across four transitions in differentiation. They present a bulk data deconvolution method and show that co-culturing human NPCs with rodent astrocyt
Externí odkaz:
https://doaj.org/article/a91415f76f3b4ff6b00a1fb9ef500aaf
Autor:
Sayan Ghosal, Qiang Chen, Giulio Pergola, Aaron L. Goldman, William Ulrich, Karen F. Berman, Giuseppe Blasi, Leonardo Fazio, Antonio Rampino, Alessandro Bertolino, Daniel R. Weinberger, Venkata S. Mattay, Archana Venkataraman
Publikováno v:
NeuroImage, Vol 238, Iss , Pp 118200- (2021)
We propose a novel optimization framework that integrates imaging and genetics data for simultaneous biomarker identification and disease classification. The generative component of our model uses a dictionary learning framework to project the imagin
Externí odkaz:
https://doaj.org/article/cf018b37d14c4dbc9f8f24dc45d26ce6