Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Karen Ellis James"'
Autor:
Karen Ellis James, Maia M. Cherney, Jie Liu, Ting-Wai Lee, James C. Powers, Michael N.G. James, Lindsay D. Eltis
Publikováno v:
Journal of Molecular Biology
The SARS coronavirus main peptidase (SARS-CoV M(pro)) plays an essential role in the life-cycle of the virus and is a primary target for the development of anti-SARS agents. Here, we report the crystal structure of M(pro) at a resolution of 1.82 Angs
Autor:
Carly Huitema, Karen Ellis James, Ting-Wai Lee, Maia M. Cherney, Jie Liu, James C. Powers, Michael N.G. James, Lindsay D. Eltis
Publikováno v:
Journal of Molecular Biology
The main peptidase (M(pro)) from the coronavirus (CoV) causing severe acute respiratory syndrome (SARS) is one of the most attractive molecular targets for the development of anti-SARS agents. We report the irreversible inhibition of SARS-CoV M(pro)
Autor:
Wendy Carter, Zhao Zhao Li, Jowita Mikolajczyk, Alan J. Barrett, James C. Powers, Juliana L. Asgian, Guy S. Salvesen, Karen Ellis James
Publikováno v:
Journal of Medicinal Chemistry. 45:4958-4960
Aza-peptide epoxides, a new class of irreversible protease inhibitors, are specific for the clan CD cysteine proteases. The inhibitors have second-order rate constants up to 10(5) M(-1) s(-1), with the most potent epoxides having the S,S stereochemis
Autor:
Juliana L Asgian, Markus G. Grütter, Amy J. Campbell, Özlem Doğan Ekici, Jowita Mikolajczyk, Karen Ellis James, James C Powers, Zhao Zhao Li, Guy S. Salvesen, Stjepan Jelakovic, Rajkumar Ganesan
Publikováno v:
Journal of medicinal chemistry. 49(19)
Aza-peptide Michael acceptors are a novel class of inhibitors that are potent and specific for caspases-2, -3, -6, -7, -8, -9, and -10. The second-order rate constants are in the order of 10(6) M(-1) s(-1). The aza-peptide Michael acceptor inhibitor
Autor:
Karen Ellis James, Jowita Mikolajczyk, Juliana L Asgian, Zhao Zhao Li, Guy S. Salvesen, John R Rubin, Özlem Doğan Ekici, James C Powers
Publikováno v:
Journal of medicinal chemistry. 47(6)
Aza-peptide epoxides, a novel class of irreversible protease inhibitors, are specific for the clan CD cysteine proteases. Aza-peptide epoxides with an aza-Asp residue at P1 are excellent irreversible inhibitors of caspases-1, -3, -6, and -8 with seco
Autor:
James C Powers, E. Hansell, Brian J Rukamp, Karen Ellis James, Guy S. Salvesen, Jan Potempa, Zhao Zhao Li, Jowita Mikolajczyk, James H. McKerrow, Jan Dvorák, James Travis, Juliana L Asgian, Özlem Doğan Ekici, Conor R. Caffrey, Marion G. Götz
Aza-peptide Michael acceptors are a new class of irreversible inhibitors that are highly potent and specific for clan CD cysteine proteases. The aza-Asp derivatives were specific for caspases, while aza-Asn derivatives were effective legumain inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f99ce2cbcfdba8d5a8690c4e1db94b29
https://ruj.uj.edu.pl/xmlui/handle/item/68517
https://ruj.uj.edu.pl/xmlui/handle/item/68517
Autor:
Karen Ellis James, Rob Lemmens, Ivonne M.J.J. van Vlijmen-Willems, Joost Schalkwijk, Diana Olthuis, Kiyotaka Hitomi, Huub J. M. Op den Camp, James C. Powers, Ikuko Hara-Nishimura, Harald T. Johansen, Patrick L.J.M. Zeeuwen
Publikováno v:
Human Molecular Genetics, 13, 10, pp. 1069-79
Human Molecular Genetics, 13, 1069-79
Human Molecular Genetics, 13, 1069-1079
Human Molecular Genetics, 13, 10, pp. 1069-1079
Human Molecular Genetics, 13, 1069-79
Human Molecular Genetics, 13, 1069-1079
Human Molecular Genetics, 13, 10, pp. 1069-1079
Contains fulltext : 149986.pdf (Publisher’s version ) (Closed access) Homozygosity for Cst6 null alleles causes the phenotype of the ichq mouse, which is a model for human harlequin ichthyosis (OMIM 242500), a genetically heterogeneous group of ker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd3ddd13997e7aad117e9145a5583779
https://doi.org/10.1093/hmg/ddh115
https://doi.org/10.1093/hmg/ddh115
Publikováno v:
Chemical reviews. 102(12)
Autor:
Marion G. Götz, Karen Ellis James, James C. Powers, Elizabeth Hansell, Jan Dvořák, Amritha Seshaadri, Daniel Sojka, James H. McKerrow, Conor R. Caffrey, Petr Kopáček
Publikováno v:
Journal of Medicinal Chemistry; Apr2008, Vol. 51 Issue 9, p2816-2832, 17p