Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karen E. Thur"'
Autor:
Helen J. Cassaday, Karen E. Thur
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
Activation of 5-hydroxytyptamine6 (5-HT6) receptors stimulates attentional switching and 5-HT6 receptor antagonists are putative drugs for psychosis. Latent inhibition (LI) provides a pre-clinical model of attentional switching and ‘antipsychotic-l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a80abf0eebf92a8d622758b5d36561
https://doi.org/10.1177/0269881119882855
https://doi.org/10.1177/0269881119882855
Publikováno v:
Biochemistry and Cell Biology. 93:581-586
Glycosphingolipids (GSLs) are hybrid molecules consisting of the sphingolipid ceramide linked to a mono- or oligo-saccharide. In comparison to other membrane lipids, the family of GSLs stands out because of the extensive variation in the carbohydrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe9cecaa7f1de4ce54e696aa45e3ab4f
https://doi.org/10.1139/bcb-2015-0074
https://doi.org/10.1139/bcb-2015-0074
Autor:
Karen E. Thur, Helen J. Cassaday
Publikováno v:
Pharmacology, Biochemistry, and Behavior
The effects of the serotonergic (5-hydroxytryptamine, 5-HT) agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT; 0.2 and 0.4 mg/kg i.p.) were examined in trace conditioning (Experiment 1) and overshadowing (Experiment 2) procedures. Both experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31b32db65b502ac630099a52fd5997e8
https://doi.org/10.1016/j.pbb.2019.172797
https://doi.org/10.1016/j.pbb.2019.172797
Autor:
Nagendra Babu Thillaiappan, Simon N. Waddington, Christina M. Ridley, Jessica Shanahan, Aarnoud C. van der Spoel, Charlotte M. Walden, Karen E. Thur, Ahad A. Rahim, Frances M. Platt, Karly Uhl, Ann Shen
Publikováno v:
Journal of Biological Chemistry. 288:26052-26066
β-Glucosidase 2 (GBA2) is an enzyme that cleaves the membrane lipid glucosylceramide into glucose and ceramide. The GBA2 gene is mutated in genetic neurological diseases (hereditary spastic paraplegia and cerebellar ataxia). Pharmacologically, GBA2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257119283e92522125db298c47724734
https://doi.org/10.1074/jbc.m113.463562
https://doi.org/10.1074/jbc.m113.463562
Publikováno v:
Neuropharmacology
The cognitive effects of MDMA (‘Ecstasy’) are controversial, particularly in the case of acute administration of low doses. Latent inhibition (LI) refers to the reduction in conditioning to a stimulus that has received non-reinforced pre-exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb2de2fef525269e75a99bfdc0743c71
https://doi.org/10.1016/j.neuropharm.2012.11.012
https://doi.org/10.1016/j.neuropharm.2012.11.012
Publikováno v:
The International Journal of Neuropsychopharmacology
Latent inhibition (LI) manifests as poorer conditioning to a stimulus that has previously been experienced without consequence. There is good evidence of dopaminergic modulation of LI, as the effect is reliably disrupted by the indirect dopamine (DA)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cef34d4e76ebde16608c87b11be0685
https://doi.org/10.1017/s1461145711001751
https://doi.org/10.1017/s1461145711001751
Publikováno v:
Advances in Medical Sciences. 56:71-79
Purpose: To examine the effect of dopamine depletion in nucleus accumbens on trace conditioning; to distinguish the role of core and shell sub-regions, as far as possible. Material/Methods: 6-hydroxydopamine was used to lesion dopamine terminals with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa91422bb506164f18210aa6aac4eccc
https://doi.org/10.2478/v10039-011-0014-2
https://doi.org/10.2478/v10039-011-0014-2
Publikováno v:
Behavioral Neuroscience
There is good evidence that the medial prefrontal cortex (mPFC) is involved in different aspects of recognition memory. However, the mPFC is a heterogeneous structure, and the contribution of the prelimbic (PL) and infralimbic (IL) cortices to recogn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a137fe1506ed6786c762479b3537e13d
https://doi.org/10.1037/a0023337
https://doi.org/10.1037/a0023337
Publikováno v:
Pharmacology, Biochemistry, and Behavior
The evidence for cognitively enhancing effects of 5-hydroxytryptamine6 (5-HT6) receptor antagonists such as Ro 04-6790 is inconsistent and seems to depend on the behavioral test variant in use. Trace conditioning holds promise as a behavioral assay f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5e2f2b01d06dbf4039664951f8518a
Publikováno v:
Journal of Psychopharmacology (Oxford, England)
Latent inhibition (LI) is demonstrated when non-reinforced pre-exposure to a to-be-conditioned stimulus retards later learning. Learning is similarly retarded in overshadowing, in this case using the relative intensity of competing cues to manipulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c305a29f9c00d4c2a1ccab9223f5e8f
http://eprints.nottingham.ac.uk/3210/
http://eprints.nottingham.ac.uk/3210/