Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Karen E. Marshall"'
Autor:
Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/8d84e8da21eb45a592eba0b8d3402fde
Autor:
Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Tau35 is a truncated form of tau found in human brain in a subset of tauopathies. Tau35 expression in mice recapitulates key features of human disease, including progressive increase in tau phosphorylation, along with cognitive and motor dysfunction.
Externí odkaz:
https://doaj.org/article/be685484133d4c3a8d3091c5db1f9df6
Autor:
Sebastian S. Oakley, Mahmoud B. Maina, Karen E. Marshall, Youssra K. Al-Hilaly, Charlie R. Harrington, Claude M. Wischik, Louise C. Serpell
Publikováno v:
Frontiers in Neurology, Vol 11 (2020)
Tau plays an important pathological role in a group of neurodegenerative diseases called tauopathies, including Alzheimer's disease, Pick's disease, chronic traumatic encephalopathy and corticobasal degeneration. In each disease, tau self-assembles a
Externí odkaz:
https://doaj.org/article/5b7b64b5eba24b5790a5b05d5ddc4ab8
Autor:
Karen E. Marshall, Kurtis Mengham, Matthew C. Spink, Lyra Vania, Hannah Jane Pollard, Michele C. Darrow, Elizabeth Duke, Maria Harkiolaki, Louise C. Serpell
Protein misfolding is common to neurodegenerative diseases (NDs) including Alzheimer’s disease (AD), which is characterized by self-assembly and accumulation of Amyloid-beta in the brain. Furthermore, impaired proteostatic mechanisms have been impl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab65cb22dc489115d6b465df851b1325
https://doi.org/10.21203/rs.3.rs-2189678/v1
https://doi.org/10.21203/rs.3.rs-2189678/v1
Autor:
Youssra K, Al-Hilaly, Karen E, Marshall, Liisa, Lutter, Luca, Biasetti, Kurtis, Mengham, Charles R, Harrington, Wei-Feng, Xue, Claude M, Wischik, Louise C, Serpell
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2551
Tau is a natively unfolded protein that contributes to the stability of microtubules. Under pathological conditions such as Alzheimer's disease (AD), tau protein misfolds and self-assembles to form paired helical filaments (PHFs) and straight filamen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d5ebe12eb3fbc8d0128307e019baa14d
https://pubmed.ncbi.nlm.nih.gov/36310203
https://pubmed.ncbi.nlm.nih.gov/36310203
Autor:
Youssra K. Al-Hilaly, Karen E. Marshall, Liisa Lutter, Luca Biasetti, Kurtis Mengham, Charles R. Harrington, Wei-Feng Xue, Claude M. Wischik, Louise C. Serpell
Publikováno v:
Methods in Molecular Biology ISBN: 9781071625965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfec2dab062f29bdce33aab424c72ec1
https://doi.org/10.1007/978-1-0716-2597-2_12
https://doi.org/10.1007/978-1-0716-2597-2_12
Autor:
Andrew Nunn, Rachel Schembri, Lauren A Booker, Peter A. Cistulli, David J Berlowitz, Karen E. Marshall, Timothy Geraghty, Bonne Lee, Andrea Townson, A. Graham, Doug Brown, Cynthia Bennett, Raj Singhal, Sue Pieri-Davies, Susan Cross, Najib T. Ayas, Deborah Short, Martin R. McClelland, Pradeep Thumbikat, Jacqueline M Ross, Marnie Graco, Sally Green
Publikováno v:
Archives of Physical Medicine and Rehabilitation. 100:2276-2282
Objective To describe continuous positive airway pressure (CPAP) use for treatment of obstructive sleep apnea (OSA) in acute tetraplegia, including adherence rates and associated factors. Design Secondary analysis of CPAP data from a multinational ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d0a9bff5cdd0c02810c21af1926616
https://doi.org/10.1016/j.apmr.2019.07.005
https://doi.org/10.1016/j.apmr.2019.07.005
Publikováno v:
Cellular and Molecular Life Sciences
Misfolding and aggregation of proteins is strongly linked to several neurodegenerative diseases, but how such species bring about their cytotoxic actions remains poorly understood. Here we used specifically-designed optical reporter probes and live f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0f2d917e21ada2d87a7560570190f8
Autor:
Astrid Nardecchia, Mahmoud Bukar Maina, Karen E. Marshall, Devkee M. Vadukul, Hannah Franklin, Louise C. Serpell
Publikováno v:
FEBS lettersReferences. 594(21)
Amyloid fibrils found in plaques in Alzheimer’s disease (AD) brains are composed of amyloid-β peptides. Oligomeric amyloid-β 1-42 (Aβ42) is thought to play a critical role in neurodegeneration in AD. Here, we determine how size and conformation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4aecc74c09ff5906dd47a246648cc26
https://pubmed.ncbi.nlm.nih.gov/32871611
https://pubmed.ncbi.nlm.nih.gov/32871611
Misfolding and aggregation of proteins is strongly linked to several neurodegenerative diseases but how such species bring about their cytotoxic actions remains poorly understood. Here we used specifically-designed optical reporter probes and live fl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e42e42a7be9c43d432182705b3757ca
https://doi.org/10.1101/598540
https://doi.org/10.1101/598540