Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Karen E. Iles"'
Autor:
Karen E. Iles, Dale A. Dickinson
Environmental health sciences is that discipline of public health that seeks to identify factors outside the body, which impact overall health, and then transmits that knowledge to the public and health-care workers to improve the health of the publi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c962d9abb902cf58b08d3088bc2d3582
https://doi.org/10.1016/b978-0-12-803678-5.00133-8
https://doi.org/10.1016/b978-0-12-803678-5.00133-8
Autor:
Jérémie Roux, Michel Carles, Brant M. Wagener, Naseem Anjum, Karen E. Iles, Mathieu Lafargue, Dong Liu, Jean-Ehrland Ricci, Jaroslaw W. Zmijewski, Jean-Francois Pittet, Cilina Rodriguez
Publikováno v:
Anesthesiology. 120:1450-1462
Background: The heat-shock response (HSR) protects from insults, such as ischemia–reperfusion injury, by inhibiting signaling pathways activated by sterile inflammation. However, the mechanisms by which the HSR activation would modulate lung damage
Autor:
Marybeth Howard, Karen E. Iles, Jérémie Roux, Dale A. Dickinson, Arnaud Goolaerts, Sarah C. Christiaans, Jean-Francois Pittet, Byron Miyazawa, Michael A. Matthay, Naseem Anjum
Publikováno v:
Shock (Augusta, Ga.), vol 39, iss 2
Acute lung injury (ALI) is a clinical syndrome characterized by hypoxia, which is caused by the breakdown of the alveolar capillary barrier. Interleukin 1β (IL-1β), a cytokine released within the airspace in ALI, downregulates the α subunit of the
Autor:
Mitchell J. Cohen, José A. Fernández, Mathieu Lafargue, Michel Carles, Nastasha Bir, Arnaud Goolaerts, Karen E. Iles, Jean-Francois Pittet, Marybeth Howard, John H. Griffin, Jérémie Roux
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 45:632-641
Inhibition of the small GTPase RhoA attenuates the development of pulmonary edema and restores positive alveolar fluid clearance in a murine model of Pseudomonas aeruginosa pneumonia. Activated protein C (aPC) blocks the development of an unfavorably
Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species
Publikováno v:
The FASEB Journal
The mechanisms by which replicating influenza viruses decrease the expression and function of amiloride-sensitive epithelial sodium channels (ENaCs) have not been elucidated. We show that expression of M2, a transmembrane influenza protein, decreases
Autor:
Praveen K. Vayalil, Ae-Kyung Yi, Edward M. Postlethwait, Karen E. Iles, Rui-Ming Liu, Jinah Choi
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 293:L1281-L1292
Transforming growth factor (TGF)-beta upregulates plasminogen activator inhibitor type 1 (PAI-1) in a variety of cell types, and PAI-1 is considered to be an essential factor for the development of fibrosis. Our previous studies demonstrated that TGF
Autor:
Anupam Agarwal, Vijay Vidyasagar, Pam Powell, Phil Chumley, Francisco J. Schopfer, Karen E. Iles, Marcienne M. Wright, Paul R. S. Baker, Bruce A. Freeman
Publikováno v:
Proceedings of the National Academy of Sciences. 103:4299-4304
Nitroalkenes are a class of cell signaling mediators generated by NO and fatty acid-dependent redox reactions. Nitrated fatty acids such as 10- and 12-nitro-9,12-octadecadienoic acid (nitrolinoleic acid, LNO 2 ) exhibit pluripotent antiinflammatory c
Autor:
Edward M. Postlethwait, Karen E. Iles, Yannick Laperche, Rui-Ming Liu, Henry Jay Forman, Honglei Liu, Hongqiao Zhang
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 34:174-181
Gamma-glutamyl transpeptidase (GGT) plays critical roles in glutathione homeostasis and metabolism. Rat GGT is a single-copy gene from which seven types of GGT mRNA with a common protein encoding sequence, but different 5'-untranslated regions, may b
Autor:
Yuqing E. Chen, Francisco J. Schopfer, Scott Sweeney, Carlos Batthyány, Yiming Lin, Paul R. S. Baker, Alison L. Groeger, Karen E. Iles, Laura M. S. Baker, Marshall H. Long, Steven R. Woodcock, Bruce P. Branchaud, Bruce A. Freeman
Publikováno v:
Journal of Biological Chemistry. 280:42464-42475
Mass spectrometric analysis of human plasma and urine revealed abundant nitrated derivatives of all principal unsaturated fatty acids. Nitrated palmitoleic, oleic, linoleic, linolenic, arachidonic and eicosapentaenoic acids were detected in concert w