Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karen E. Duffy"'
Autor:
Patrick Branigan, Zhenhua Xu, Ivo Nnane, Philipp Badorrek, Damien Fink, Donald Raible, Zhenling Yao, Karen E. Duffy, Maarten van den Boer, Cathye Shu, Bart Frederick, Tong-Yuan Yang, Frédéric Baribaud
Publikováno v:
Br J Clin Pharmacol
Aims To assess safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD) and immunogenicity of CNTO 7160, an anti-interleukin-33 receptor (IL-33R) monoclonal antibody, in healthy subjects and patients with asthma or atopic dermatitis (AD). M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56489b453857e0b285608f97a6b7f8fe
https://doi.org/10.1111/bcp.14361
https://doi.org/10.1111/bcp.14361
Autor:
Robert A. Lamb, Yawei Li, Ramachandra Reddy, Brian Jones, Eilyn R. Lacy, Angela Filer, Jin Lu, Catherine Healy, Changbao Liu, Karen E. Duffy, Ted Petley, Sheng-Jiun Wu, Natalie Fursov
Publikováno v:
Molecular immunology. 75
The cell-surface receptor ST2L triggers cytokine release by immune cells upon exposure to its ligand IL-33. To study the effect of ST2L-dependent signaling in different cell types, we generated antagonist antibodies that bind different receptor domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee1f6831b509492255249ceba4d8773
https://pubmed.ncbi.nlm.nih.gov/27294560
https://pubmed.ncbi.nlm.nih.gov/27294560
Autor:
Anuk Das, Natalie Fursov, Geoffrey L. Chupp, Hemanth Ramaprakash, Cory M. Hogaboam, Ugur B. Ismailoglu, Karen E. Duffy, Ana Paula Moreira, Ana Lucia Coelho, Takehiko Shibata, Rachel M. Bredernitz
Publikováno v:
The American Journal of Pathology. 179:104-115
IL-33 and its soluble receptor and cell-associated receptor (ST2L) are all increased in clinical and experimental asthma. The present study addressed the hypothesis that ST2L impairs the therapeutic effects of CpG in a fungal model of asthma. C57BL/6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7fc9d8c61250ad789fc136fca28b2dd
https://doi.org/10.1016/j.ajpath.2011.03.032
https://doi.org/10.1016/j.ajpath.2011.03.032
Autor:
Jill Giles-Komar, Erin Johnston, Natalie Fursov, Michael A. Rycyzyn, Haiyan Jiang, Gordon Powers, Karen E. Duffy, Jamie Fisher, Theodore Petley, Adam Cotty
Publikováno v:
Hybridoma. 30:153-162
ST2L is a transmembrane receptor that belongs to the IL-1 receptor family. The receptor is expressed on various cell types including Th2 cells, mast cells, basophils, growth-activated fibroblasts, and vascular endothelial cells. ST2L activation by it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584cc867a0af6035d68b074740c82abf
https://doi.org/10.1089/hyb.2010.0100
https://doi.org/10.1089/hyb.2010.0100
Autor:
Karen E. Duffy, Rachel A Bunting, Lena Alexopoulou, Karen A Smalley, Heena Beck, Richard A. Flavell, Ted Petley, Xuesong Liu, Jamie Fisher, Lani San Mateo, Christine K. Ward, Roberta J. Lamb, Holly Raymond
Publikováno v:
Cellular Immunology. 267:9-16
Toll-like receptor 3 (TLR3) binds and signals in response to dsRNA and poly(I:C), a synthetic double stranded RNA analog. Activation of TLR3 triggers innate responses that may play a protective or detrimental role in viral infections or in immune-med
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f599a64692671013578181b4d4ebeed
https://doi.org/10.1016/j.cellimm.2010.10.008
https://doi.org/10.1016/j.cellimm.2010.10.008
Autor:
Scott A. Hoose, C. Cheng Kao, Jarrat Jordan, Roberta J. Lamb, Karen E. Duffy, Robert T. Sarisky, Robert C. Vaughan, C. T. Ranjith-Kumar, A. Eaton-Bassiri
Publikováno v:
Molecular and Cellular Biology
Toll-like receptor 3 (TLR3) can signal the production of a suite of cytokines and chemokines in response to double-stranded RNA (dsRNA) ligands or the dsRNA mimic poly(I-C). Using a human embryonic kidney 293T cell line to express human TLR3, we dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5410c8f539c49f77dac4466af824f064
https://doi.org/10.1128/mcb.00308-08
https://doi.org/10.1128/mcb.00308-08
Autor:
Jeremy Korteweg, Jill Carton, Mark Cunningham, Michael Brigham-Burke, Heena Beck, M. Lamine Mbow, Jill Giles-Komar, Roberta J. Lamb, Robert T. Sarisky, Jarrat Jordan, Lani San Mateo, Karen E. Duffy, Cynthia Duchala, Gabriela Canziani
Publikováno v:
Cellular Immunology. 248:103-114
Toll-like receptors are a family of pattern-recognition receptors that contribute to the innate immune response. Toll-like receptor 3 (TLR3) signals in response to foreign, endogenous and synthetic ligands including viral dsRNA, bacterial RNA, mitoch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0e3dc09253b69faebf92cdd4bb781cc
https://doi.org/10.1016/j.cellimm.2007.10.002
https://doi.org/10.1016/j.cellimm.2007.10.002
Autor:
Karen E. Duffy, Conway C. Huang, Bernard Y. Amegadzie, Robert T. Sarisky, M. Lamine Mbow, Lani San Mateo
Publikováno v:
Physiological Genomics. 26:125-133
To gain global pathway perspective of ex vivo viral infection models using human peripheral blood mononuclear cells (PBMCs), we conducted expression analysis on PBMCs of healthy donors. RNA samples were collected at 3 and 24 h after PBMCs were challe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a627c68db95ceea2cca0723fa590d85
https://doi.org/10.1152/physiolgenomics.00002.2006
https://doi.org/10.1152/physiolgenomics.00002.2006
Autor:
Hema Masarapu, Andreas Holzenburg, Mark Cunningham, Jon Santos, M. Lamine Mbow, Jingchuan Sun, Jin Xiong, Karen E. Duffy, Robert T. Sarisky, Roberta J. Lamb, C. Cheng Kao, C. T. Ranjith-Kumar
Publikováno v:
Journal of Biological Chemistry. 281:11144-11151
Toll-like receptors (TLRs) play critical roles in bridging the innate and adaptive immune responses. The human TLR3 recognizes foreign-derived double-stranded RNA and endogenous necrotic cell RNA as ligands. Herein we characterized the contribution o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4490276581a235b9fb40fa3c9e728040
https://doi.org/10.1074/jbc.m510442200
https://doi.org/10.1074/jbc.m510442200
Publikováno v:
Antimicrobial Agents and Chemotherapy. 44:1524-1529
Spontaneous mutations within the herpes simplex virus (HSV) genome are introduced by errors during DNA replication. Indicative of the inherent mutation rate of HSV DNA replication, heterogeneous HSV populations containing both acyclovir (ACV)-resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c458f5b381297c992551f0bea6cc1598
https://doi.org/10.1128/aac.44.6.1524-1529.2000
https://doi.org/10.1128/aac.44.6.1524-1529.2000