Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Karen E. Boschen"'
Publikováno v:
Disease Models & Mechanisms, Vol 14, Iss 6 (2021)
Genetics are a known contributor to differences in alcohol sensitivity in humans with fetal alcohol spectrum disorders (FASDs) and in animal models. Our study profiled gene expression in gastrulation-stage embryos from two commonly used, genetically
Externí odkaz:
https://doaj.org/article/874245c3cb784d4891acb702ec9263a5
Publikováno v:
Brain Sciences, Vol 3, Iss 1, Pp 1-38 (2012)
Developmental alcohol exposure both early in life and during adolescence can have a devastating impact on normal brain structure and functioning, leading to behavioral and cognitive impairments that persist throughout the lifespan. This review discus
Externí odkaz:
https://doaj.org/article/473785958e9a483eb6a3fe64bb40b837
Publikováno v:
Alcohol. 106:1-9
Alcohol exposure during the formation and closure of the neural tube, or neurulation (embryonic day [E] 8-10 in mice; ∼4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53e48bdabf243f087aabd091967a869c
https://doi.org/10.1016/j.alcohol.2022.09.001
https://doi.org/10.1016/j.alcohol.2022.09.001
Autor:
Eric W. Fish, Haley N. Mendoza‐Romero, Charlotte A. Love, Constance J. Dragicevich, Michael D. Cannizzo, Karen E. Boschen, Austin Hepperla, Jeremy M. Simon, Scott E. Parnell
Publikováno v:
Birth Defects Research. 114:1229-1243
During early development, alcohol exposure causes apoptotic cell death in discrete regions of the embryo which are associated with distinctive patterns of later-life abnormalities. In gastrulation, which occurs during the third week of human pregnanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d8ec58d3de394ad5051142d436cb0f
https://doi.org/10.1002/bdr2.2009
https://doi.org/10.1002/bdr2.2009
Publikováno v:
Reprod Toxicol
Neurulation-stage alcohol exposure (NAE; embryonic day [E] 8–10) is associated with midline craniofacial and CNS defects that likely arise from disruption of morphogen pathways, such as Sonic hedgehog (Shh). Notably, midline anomalies are also a ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3339787af96b39e8d873047dfcdd5751
https://doi.org/10.1016/j.reprotox.2021.09.002
https://doi.org/10.1016/j.reprotox.2021.09.002
Publikováno v:
Alcohol Clin Exp Res
BACKGROUND: Early gestational alcohol exposure is associated with severe craniofacial and CNS dysmorphologies and behavioral abnormalities during adolescence and adulthood. Alcohol exposure during the formation of the neural tube (gestational day [GD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fb87f6f66419291b0c8e3a0ff7e700a
https://pubmed.ncbi.nlm.nih.gov/32557641
https://pubmed.ncbi.nlm.nih.gov/32557641
Autor:
Haley N. Mendoza-Romero, Eric W. Fish, Somnath Mukhopadhyay, Laura B. Murdaugh, Gregory J. Cole, Kevin P. Williams, Scott E. Parnell, Chengjin Zhang, Oswald Boa-Amponsem, Lhoucine Chdid, Michael Tarpley, Karen E. Boschen
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
We tested whether cannabinoids (CBs) potentiate alcohol-induced birth defects in mice and zebrafish, and explored the underlying pathogenic mechanisms on Sonic Hedgehog (Shh) signaling. The CBs, Δ9-THC, cannabidiol, HU-210, and CP 55,940 caused alco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::306800fa432ec808bf40a53c577a39f6
http://europepmc.org/articles/PMC6831672
http://europepmc.org/articles/PMC6831672
Neurulation-stage alcohol exposure (NAE; embryonic day [E] 8-10) is associated with midline craniofacial and CNS defects that likely arise from disruption of morphogen pathways, such as Sonic hedgehog (Shh). Notably, midline anomalies are also a hall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73ec372da2ab2e9471078d24e3bbc3ef
Publikováno v:
Developmental Neurobiology. 77:708-725
Alcohol exposure in utero can result in Fetal Alcohol Spectrums Disorders (FASD). Measures of hippocampal neuroplasticity, including long-term potentiation, synaptic and dendritic organization, and adult neurogenesis, are consistently disrupted in ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::728cf899a13fc29be21fa30a683754f7
https://doi.org/10.1002/dneu.22448
https://doi.org/10.1002/dneu.22448
Publikováno v:
Neuroscience. 324:355-366
Aberrant activation of the developing immune system can have long-term negative consequences on cognition and behavior. Teratogens, such as alcohol, activate microglia, the brain’s resident immune cells, which could contribute to the lifelong defic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac03a91725ca58fe69d210592c7022c
https://doi.org/10.1016/j.neuroscience.2016.03.033
https://doi.org/10.1016/j.neuroscience.2016.03.033