Výsledky vyhledávání - "Karen E. Beagles"

Akademický článek

Comparison of Mesenchymal Stem Cells from Different Tissues to Suppress T-Cell Activation

Autor: Kirsten A. Keyser, Karen E. Beagles, Hans-Peter Kiem

Publikováno v: Cell Transplantation, Vol 16 (2007)

Graft-versus-host disease (GvHD) and graft rejection have remained significant complications of allogeneic stem cell transplantation. Mesenchymal stem cells (MSCs) from the bone marrow have been shown to suppress T-cell activation in vitro and in viv

Externí odkaz: https://doaj.org/article/cfd355c0472346649d70895cb769b335

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Quinolinic Acid Is Extruded from the Brain by a Probenecid-Sensitive Carrier System: A Quantitative Analysis

Autor: Paul F. Morrison, Melvyn P. Heyes, Karen E. Beagles, Gregory M. Morishige

Publikováno v: Journal of Neurochemistry. 72:2135-2144

Although the neurotoxic tryptophan-kynurenine pathway metabolite quinolinic acid originates in brain by both local de novo synthesis and entry from blood, its concentrations in brain parenchyma, extracellular fluid, and CSF are normally below blood v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce65d6824763021c357cefee61f7f263
https://doi.org/10.1046/j.1471-4159.1999.0722135.x

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Quinolinic Acid In Vivo Synthesis Rates, Extracellular Concentrations, and Intercompartmental Distributions in Normal and Immune-Activated Brain as Determined by Multiple-Isotope Microdialysis

Autor: Karen E. Beagles, Melvyn P. Heyes, Paul F. Morrison

Publikováno v: Journal of Neurochemistry. 70:281-291

Quinolinic acid (QUIN) kills neurons by activation of NMDA receptors that are accessed via the extracellular fluid (ECF). In vivo microdialysis was employed to quantify the dynamics of ECF QUIN levels. [(13)C7]QUIN was perfused through the probe for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c78a3f33c81c2bb94abc135cbcde7d0
https://doi.org/10.1046/j.1471-4159.1998.70010281.x

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Species heterogeneity between gerbils and rats: quinolinate production by microglia and astrocytes and accumulations in response to ischemic brain injury and systemic immune activation

Autor: Melvyn P. Heyes, Ju Li, Margit G. Proescholdt, Sanford P. Markey, Cai Y. Chen, Kensuke Kawai, Martin A. Proescholdt, Mark Zito, Thaddeus S. Nowak, Kuniaki Saito, Karen E. Beagles

Publikováno v: Journal of neurochemistry. 69(4)

Quinolinic acid is an excitotoxic kynurenine pathway metabolite, the concentration of which increases in human brain during immune activation. The present study compared quinolinate responses to systemic and brain immune activation in gerbils and rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd4b39e57ac53f5d632be8278f0b41d
https://pubmed.ncbi.nlm.nih.gov/9326281

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