Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Karen E Porter"'
Autor:
Alisah Hussain, Yaw Asare-Amankwah, Shehryar Qureshi, M. Julie Thornton, Timothy M. Palmer, Israel O. Bolanle, Ian C. Wood, Neil A. Turner, Karen E. Porter, Andrew Tedder, Kirsten Riches-Suman
Publikováno v:
Diabetology, Vol 5, Iss 2, Pp 178-189 (2024)
Type 2 diabetes mellitus (T2DM) patients suffer premature development of cardiovascular disease and commonly require cardiac revascularization using the autologous saphenous vein (SV). Smooth muscle cells (SMCs) are the principal cell type within the
Externí odkaz:
https://doaj.org/article/15f145fa74e24a0589f43ea88e26c4cd
Autor:
Sara D Pugh, David A MacDougall, Shailesh R Agarwal, Robert D Harvey, Karen E Porter, Sarah Calaghan
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106905 (2014)
The number of people taking statins is increasing across the globe, highlighting the importance of fully understanding statins' effects on the cardiovascular system. The beneficial impact of statins extends well beyond regression of atherosclerosis t
Externí odkaz:
https://doaj.org/article/dd91de595505428ea0da847f5f3119e5
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34747 (2012)
The angiotensin converting enzymes (ACEs) are the key catalytic components of the renin-angiotensin system, mediating precise regulation of blood pressure by counterbalancing the effects of each other. Inhibition of ACE has been shown to improve path
Externí odkaz:
https://doaj.org/article/d4683c853a8446b58faf39c900a72ef6
Autor:
Gemma K. Lyall, Gurpreet K. Birk, Emma Harris, Carrie Ferguson, Kirsten Riches‐Suman, Mark T. Kearney, Karen E. Porter, Karen M. Birch
Publikováno v:
Physiological Reports, Vol 10, Iss 16, Pp n/a-n/a (2022)
Abstract Background Menopause represents a turning point where vascular damage begins to outweigh reparative processes, leading to increased cardiovascular disease (CVD) risk. Exercise training reduces CVD risk in postmenopausal females via improveme
Externí odkaz:
https://doaj.org/article/c6a4f06f1d584b7c8c8a0cf352e8fb84
Autor:
Karen E Hemmings, Natalie J Haywood, Katherine I Bridge, Andrew Walker, Hema Viswambharan, Katie J. Simmons, Richard M Cubbon, Karen E. Porter, Ajay M. Shah, Jane Brown, David J. Beech, Emily R. Clark, Natallia Makava, Mark T. Kearney, Yilizila Abudushalamu, Khalid M. Naseem, Stephen B. Wheatcroft, Helen Imrie, Anna Skromna, V Kate Gatenby, Naima Endesh, Nadira Yuldasheva, Piruthivi Sukumar, T. Simon Futers, Paul A. Cordell
Publikováno v:
Circulation Research
Supplemental Digital Content is available in the text.
Rationale: A hallmark of type 2 diabetes is insulin resistance, which leads to increased endothelial cell (EC) production of superoxide and a simultaneous reduction in the availability of th
Rationale: A hallmark of type 2 diabetes is insulin resistance, which leads to increased endothelial cell (EC) production of superoxide and a simultaneous reduction in the availability of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9060219ad1bcabd2b1ca0baba0d5a0bb
https://eprints.whiterose.ac.uk/177316/16/CIRCRESAHA.121.319517.pdf
https://eprints.whiterose.ac.uk/177316/16/CIRCRESAHA.121.319517.pdf
Autor:
Karen E. Porter, Frans A. van Nieuwenhoven, Vasili Stylianidis, Richard Foster, Nicola M Blythe, Neil A. Turner, Katsuhiko Muraki, Jing Li, Hamish T. J. Gilbert, Kevin Cuthbertson, Mark J. Drinkhill, David J. Beech, Elizabeth L. Evans, Joe Swift, Melanie J. Ludlow
Publikováno v:
Journal of Biological Chemistry, 294(46), 17395-17408. American Society for Biochemistry and Molecular Biology, Inc.
Blythe, N M, Muraki, K, Ludlow, M J, Stylianidis, V, Gilbert, H T J, Evans, E L, Cuthbertson, K, Foster, R, Swift, J, Li, J, Drinkhill, M J, van Nieuwenhoven, F A, Porter, K E, Beech, D J & Turner, N A 2019, ' Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion ', The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA119.009167
The Journal of Biological Chemistry
Blythe, N M, Muraki, K, Ludlow, M J, Stylianidis, V, Gilbert, H T J, Evans, E L, Cuthbertson, K, Foster, R, Swift, J, Li, J, Drinkhill, M J, van Nieuwenhoven, F A, Porter, K E, Beech, D J & Turner, N A 2019, ' Mechanically activated Piezo1 channels of cardiac fibroblasts stimulate p38 mitogen-activated protein kinase activity and interleukin-6 secretion ', The Journal of biological chemistry . https://doi.org/10.1074/jbc.RA119.009167
The Journal of Biological Chemistry
Piezo1 is a mechanosensitive cation channel with widespread physiological importance; however, its role in the heart is poorly understood. Cardiac fibroblasts help preserve myocardial integrity and play a key role in regulating its repair and remodel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9105908f59f377a695a247e5ae82f4b9
https://doi.org/10.1074/jbc.ra119.009167
https://doi.org/10.1074/jbc.ra119.009167
Autor:
Lee D. Roberts, Karen E. Porter, Chris Peers, Moza M. Al-Owais, Aisling Minard, Robin S. Bon, Nishani T. Hettiarachchi, Jason L. Scragg, Eulashini Chuntharpursat-Bon, Piruthivi Sukumar, Faye L. Styles, Jonathan D. Lippiat
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Cellular energy metabolism is fundamental for all biological functions. Cellular proliferation requires extensive metabolic reprogramming and has a high energy demand. The Kv1.3 voltage-gated potassium channel drives cellular proliferation. Kv1.3 cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a2f1285293c271db0c08d5bd308c1a6
Autor:
Karen E. Porter, Neil A. Turner, David J. O'Regan, Kirsten Riches-Suman, Marc A. Bailey, Karen E Hemmings
Publikováno v:
Cells
Cells, Vol 10, Iss 919, p 919 (2021)
Volume 10
Issue 4
Cells, Vol 10, Iss 919, p 919 (2021)
Volume 10
Issue 4
Increased cardiovascular morbidity and mortality in individuals with type 2 diabetes (T2DM) is a significant clinical problem. Despite advancements in achieving good glycaemic control, this patient population remains susceptible to macrovascular comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793eed8e1f522f160a0cc97fb37968b6
http://europepmc.org/articles/PMC8073820
http://europepmc.org/articles/PMC8073820
Autor:
Karen E Hemmings, Richard Foster, Karen E. Porter, Marc A. Bailey, Heba Shawer, David J. Beech
Publikováno v:
Circulation. 142
Vascular smooth muscle cells (VSMC) are physiologically quiescent cells optimised for vascular contractility and the modulation of vascular tone. Platelet-derived growth factor (PDGF) signalling is a critical driver of pathological remodelling of nat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2f97ef173ccd4b4ac45efd23a558d2d7
https://doi.org/10.1161/circ.142.suppl_3.16436
https://doi.org/10.1161/circ.142.suppl_3.16436
Autor:
Karen E. Porter, Neil A. Turner, Karen E Hemmings, Kirsten Riches-Suman, Marc A. Bailey, David J. O'Regan
Increased cardiovascular morbidity and mortality in individuals with type 2 diabetes (T2DM) is a significant clinical problem. Despite advancements in achieving good glycaemic control, this patient population remains susceptible to macrovascular comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b967871c61efc41b97dcdb61a1e03d5c
https://doi.org/10.1101/2020.08.12.248542
https://doi.org/10.1101/2020.08.12.248542