Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Karen E Olson"'
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101932 (2014)
Group I introns are pre-mRNA introns that do not require the spliceosome for their removal. Instead, they fold into complex three-dimensional structures and catalyze two transesterification reactions, thereby excising themselves and joining the flank
Externí odkaz:
https://doaj.org/article/4c1aafcf84af416b840e3feb2c07887c
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86473 (2014)
How does a non-coding RNA evolve in cells? To address this question experimentally we evolved a trans-splicing variant of the group I intron ribozyme from Tetrahymena over 21 cycles of evolution in E.coli cells. Sequence variation was introduced duri
Externí odkaz:
https://doaj.org/article/b377cb67b6cd4aff99797f892a65d256
Autor:
Martin Rylance, Hans-Henrik Kogsbøll, Craig Cipolla, Carl T. Montgomery, Michael B. Smith, W. David Norman, Karen E. Olson, C. Mark Pearson
Publikováno v:
Day 2 Wed, February 01, 2023.
The focus on unconventional technology and operations, has been relentless during the last 15 - 20 years, while conventional operations have continued to tick along delivering their effective solutions globally. However, with unconventional operation
Autor:
Karen E. Olson
This astonishing crime novel—inspired by the Tudor era—takes the reader into the world of Kate Parker, who has just married billionaire Hank Tudor when a headless body is discovered near their summer home...Kate Parker knows what she's getting in
Autor:
Karen E. Olson
A computer hacker on the run heads to Paris to get answers but the truth may come at a price in this technothriller from the author of Betrayed.With a price on her head, computer hacker Tina Adler is determined to stay offline. Only one person knows
Autor:
Karen E. Olson
A computer hacker working to clear her name discovers a dangerous threat could closer than she knows in this technothriller from the author of Hidden. Framed for ordering a hit on mobster Tony DeMarco, Tina Adler is forced to re-enter the shadowy wor
Autor:
Karen E. Olson
An ex-cyberthief is on the run from her past in an “electrifying” thriller by the author of Hidden: “an addictive page-turner with a stunner of a finale” (Kirkus Reviews). For fifteen years, her name was Nicole Jones. Then her criminal past c
Autor:
Karen E. Olson
A computer hacker's criminal past comes back to haunt her in this “edge-of-your-seat thriller” from the author of Vanished (Alison Gaylin, USA Today–bestselling author). Nicole Jones lives off the grid. She doesn't have a driver's license, pass
Autor:
Karen E. Olson, Ulrich Müller
Publikováno v:
RNA. 18:581-589
Group I intron ribozymes can repair mutated mRNAs by replacing the 3′-terminal portion of the mRNA with their own 3′-exon. This trans-splicing reaction has the potential to treat genetic disorders and to selectively kill cancer cells or virus-inf