Effect of genome and environment on metabolic and inflammatory profiles.

Autor: Marina Sirota, Gonneke Willemsen, Purnima Sundar, Steven J Pitts, Shobha Potluri, Edi Prifti, Sean Kennedy, S Dusko Ehrlich, Jacoline Neuteboom, Cornelis Kluft, Karen E Malone, David R Cox, Eco J C de Geus, Dorret I Boomsma

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0120898 (2015)

Twin and family studies have established the contribution of genetic factors to variation in metabolic, hematologic and immunological parameters. The majority of these studies analyzed single or combined traits into pre-defined syndromes. In the pres

Externí odkaz: https://doaj.org/article/55fb8342b93a4d4d9dde147197d97bf2

Antimicrobial Peptide Omiganan Enhances Interferon Responses to Endosomal Toll‐Like Receptor Ligands in Human Peripheral Blood Mononuclear Cells

Autor: Karen E. Malone, Matthijs Moerland, Silvana M.G. Jirka, Tess D. Woutman, G. Feiss, Hendrika W. Grievink, Robert Rissmann, Mascha Schoonakker

Publikováno v: Clinical and Translational Science
Clinical and Translational Science, Vol 13, Iss 5, Pp 891-895 (2020)
Clinical and Translational Science, 13(5), 891-895. WILEY

LL-37 is a cationic antimicrobial peptide and the sole human member of cathelicidins. Besides its bactericidal properties, LL-37 is known to have direct immunomodulatory effects, among which enhancement of antiviral responses via endosomal toll-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d551a15881fccbd3c49390b4f1f8fd8
http://europepmc.org/articles/PMC7485948

Genetic epidemiology approach to estimating birth incidence and current disease prevalence for rhizomelic chondrodysplasia punctata

Autor: Shawn Ritchie, Tarik Luisman, Tara C. Smith, Karen E. Malone

Publikováno v: Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-8 (2021)

Background Rhizomelic chondrodysplasia punctata (RCDP) is an inherited ultra-rare disease which results in severely impaired physical and mental development. Mutations in one of five genes involved in plasmalogen biosynthesis have been reported to dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83f0b25f775484aba9a2ac1381b6130f
https://pubmed.ncbi.nlm.nih.gov/34229749

Whole blood assay as a model for in vitro evaluation of inflammasome activation and subsequent caspase-mediated interleukin-1 beta release

Autor: Matthijs Moerland, Jacobus Burggraaf, Dimitar Tasev, Karen E. Malone, Hendrika W. Grievink, Cornelis Kluft, Thi Anh Thu Tran, Katarzyna Lipinska

Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 4, p e0214999 (2019)

Processing of pro-interleukin (IL)-1β and IL-18 is regulated by multiprotein complexes, known as inflammasomes. Inflammasome activation results in generation of bioactive IL-1β and IL-18, which can exert potent pro-inflammatory effects. Our aim was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af383dcebdb2f040599f30cea587d56b
http://europepmc.org/articles/PMC6453527

MDCO-216 Does Not Induce Adverse Immunostimulation, in Contrast to Its Predecessor ETC-216

Autor: Matthijs Moerland, Joannes A. A. Reijers, David Kallend, J. Burggraaf, Peter L.J. Wijngaard, Johan Wouter Jukema, Karen E. Malone

Publikováno v: Cardiovascular Drugs and Therapy
Cardiovascular Drugs and Therapy, 31(4), 381-389

Purpose Aim of this study was to demonstrate that MDCO-216 (human recombinant Apolipoprotein A-I Milano) does not induce adverse immunostimulation, in contrast to its predecessor, ETC-216, which was thought to contain host cell proteins (HCPs) that e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc959458f237293ef5178c3986e87b95
https://hdl.handle.net/1887/95096