Výsledky vyhledávání - "Karen E Kempsell"

Akademický článek

Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype.

Autor: James Ross Cooper, Muhammad Bilal Abdullatif, Edward C Burnett, Karen E Kempsell, Franco Conforti, Howard Tolley, Jane E Collins, Donna E Davies

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164438 (2016)

Pulmonary research requires models that represent the physiology of alveolar epithelium but concerns with reproducibility, consistency and the technical and ethical challenges of using primary or stem cells has resulted in widespread use of continuou

Externí odkaz: https://doaj.org/article/df08cee82f3c4168936d7f0b2349f097

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Akademický článek

Temporal Expression of Peripheral Blood Leukocyte Biomarkers in a Macaca fascicularis Infection Model of Tuberculosis; Comparison with Human Datasets and Analysis with Parametric/Non-parametric Tools for Improved Diagnostic Biomarker Identification.

Autor: Sajid Javed, Leanne Marsay, Alice Wareham, Kuiama S Lewandowski, Ann Williams, Michael J Dennis, Sally Sharpe, Richard Vipond, Nigel Silman, Graham Ball, Karen E Kempsell

Publikováno v: PLoS ONE, Vol 11, Iss 5, p e0154320 (2016)

A temporal study of gene expression in peripheral blood leukocytes (PBLs) from a Mycobacterium tuberculosis primary, pulmonary challenge model Macaca fascicularis has been conducted. PBL samples were taken prior to challenge and at one, two, four and

Externí odkaz: https://doaj.org/article/ac8b5b308364458d806563b68366957d

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Akademický článek

The ‘analysis of gene expression and biomarkers for point-of-care decision support in Sepsis‘ study; temporal clinical parameter analysis and validation of early diagnostic biomarker signatures for severe inflammation andsepsis-SIRS discrimination

Autor: Tamas Szakmany, Eleanor Fitzgerald, Harriet N. Garlant, Tony Whitehouse, Tamas Molnar, Sanjoy Shah, Dong Ling Tong, Judith E. Hall, Graham R. Ball, Karen E. Kempsell

Publikováno v: Frontiers in Immunology, Vol 14 (2024)

IntroductionEarly diagnosis of sepsis and discrimination from SIRS is crucial for clinicians to provide appropriate care, management and treatment to critically ill patients. We describe identification of mRNA biomarkers from peripheral blood leukocy

Externí odkaz: https://doaj.org/article/e2e53056187d42e986309d120efa0695

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Evaluation of Host Protein Biomarkers by ELISA From Whole Lysed Peripheral Blood for Development of Diagnostic Tests for Active Tuberculosis

Autor: Harriet N. Garlant, Kalaiarasan Ellappan, Matthew Hewitt, Prem Perumal, Simon Pekeleke, Nadina Wand, Jo Southern, Saka Vinod Kumar, Harish Belgode, Ibrahim Abubakar, Sanjeev Sinha, Seshadri Vasan, Noyal Mariya Joseph, Karen E. Kempsell

Publikováno v: Frontiers in Immunology. 13

Tuberculosis (TB) remains a significant global health crisis and the number one cause of death for an infectious disease. The health consequences in high-burden countries are significant. Barriers to TB control and eradication are in part caused by d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ef288232232b59769017c5fa36b3034

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Validation of Differentially Expressed Immune Biomarkers in Latent and Active Tuberculosis by Real-Time PCR

Autor: Marc Lipman, Timothy D. McHugh, Karen E. Kempsell, Mohamed Bilal Abdullatif, Prem Perumal, Isobella Honeyborne, Harriet N. Garlant, Seshadri S. Vasan, Ronan Breen, Sanjeev Sinha, Harish Narasimha Belgode, George Santis, Jo Southern, Noyal Mariya Joseph, Ibrahim Abubakar, Saka Vinod Kumar, Kalaiarasan Ellappan

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2021)

Tuberculosis (TB) remains a major global threat and diagnosis of active TB ((ATB) both extra-pulmonary (EPTB), pulmonary (PTB)) and latent TB (LTBI) infection remains challenging, particularly in high-burden countries which still rely heavily on conv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2ae29c657e2e203828abdd484cd63e
http://europepmc.org/articles/PMC8029985

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Development of a Bioinformatics Framework for Identification and Validation of Genomic Biomarkers and Key Immunopathology Processes and Controllers in Infectious and Non-infectious Severe Inflammatory Response Syndrome

Autor: Dong Ling Tong, Karen E. Kempsell, Tamas Szakmany, Graham Ball

Publikováno v: Frontiers in Immunology
Frontiers in Immunology, Vol 11 (2020)

Sepsis is defined as dysregulated host response caused by systemic infection, leading to organ failure. It is a life-threatening condition, often requiring admission to an intensive care unit (ICU). The causative agents and processes involved are mul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e11773d6e0c8ad79877dc7aba933a6
https://doi.org/10.3389/fimmu.2020.00380

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Development and Assessment of a Diagnostic DNA Oligonucleotide Microarray for Detection and Typing of Meningitis-Associated Bacterial Species

Autor: Sonal Shah, Peter Marsh, Stephen P Kidd, Michael J. Elmore, Andrew Telfer Brunton, Richard Vipond, Steve M. Green, Stephanie A Bannister, Anvy Thomas, Karen E. Kempsell, Elizabeth Kirby, Nigel Silman

Publikováno v: High-Throughput
Volume 7
Issue 4
High-Throughput, Vol 7, Iss 4, p 32 (2018)

Meningitis is commonly caused by infection with a variety of bacterial or viral pathogens. Acute bacterial meningitis (ABM) can cause severe disease, which can progress rapidly to a critical life-threatening condition. Rapid diagnosis of ABM is criti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a6bc93977b2337a702b7c49bb04b818

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Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype

Autor: Donna E. Davies, Franco Conforti, James Ross Cooper, Howard Tolley, Karen E. Kempsell, Muhammad Bilal Abdullatif, Jane E. Collins, Edward C. Burnett

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0164438 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cb6c6a26cc48ef00fa33eb46363bdd
https://pubmed.ncbi.nlm.nih.gov/27792742

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Autor: Graham Ball, Mike Dennis, Sally Sharpe, Ann Williams, Sajid Javed, Richard Vipond, Nigel Silman, Alice Wareham, Kuiama S. Lewandowski, Leanne Marsay, Karen E. Kempsell

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 5, p e0154320 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::898f98d695f45122046998c869172e70
http://europepmc.org/articles/PMC4882019

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