Zobrazeno 1 - 10
of 217
pro vyhledávání: '"Karen E, Pollok"'
Autor:
Kexin Li, Xun Sun, Hudie Li, Hailan Ma, Meng Zhou, Kazumasa Minami, Keisuke Tamari, Kazuhiko Ogawa, Pankita H. Pandya, M. Reza Saadatzadeh, Melissa A. Kacena, Karen E. Pollok, Bai-Yan Li, Hiroki Yokota
Publikováno v:
Genes and Diseases, Vol 10, Iss 4, Pp 1641-1656 (2023)
Cancer cells tend to develop resistance to chemotherapy and enhance aggressiveness. A counterintuitive approach is to tame aggressiveness by an agent that acts opposite to chemotherapeutic agents. Based on this strategy, induced tumor-suppressing cel
Externí odkaz:
https://doaj.org/article/d040b7e31d9e44aebea1c63c1d145289
Autor:
Nur P. Damayanti, M. Reza Saadatzadeh, Erika Dobrota, Josue D. Ordaz, Barbara J. Bailey, Pankita H. Pandya, Khadijeh Bijangi-Vishehsaraei, Harlan E. Shannon, Anthony Alfonso, Kathy Coy, Melissa Trowbridge, Anthony L. Sinn, Zhong-Yin Zhang, Rosa I. Gallagher, Julia Wulfkuhle, Emanuel Petricoin, Angela M. Richardson, Mark S. Marshall, Alex Lion, Michael J. Ferguson, Karl E. Balsara, Karen E. Pollok
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)
Abstract Pleomorphic xanthoastrocytoma (PXA) is a rare subset of primary pediatric glioma with 70% 5-year disease free survival. However, up to 20% of cases present with local recurrence and malignant transformation into more aggressive type anaplast
Externí odkaz:
https://doaj.org/article/e5789262b3ec42119349962b8c13096b
TIGIT contributes to the regulation of 4-1BB and does not define NK cell dysfunction in glioblastoma
Autor:
Kyle B. Lupo, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, Aaron A. Cohen-Gadol, Veronika Slivova, MacKenzie McIntosh, Karen E. Pollok, Sandro Matosevic
Publikováno v:
iScience, Vol 26, Iss 12, Pp 108353- (2023)
Summary: TIGIT is a receptor on human natural killer (NK) cells. Here, we report that TIGIT does not spontaneously induce inhibition of NK cells in glioblastoma (GBM), but rather acts as a decoy-like receptor, by usurping binding partners and regulat
Externí odkaz:
https://doaj.org/article/fc412162de6f40f686eec4555f885cb5
Autor:
Qiaomu Tian, Peng Zhang, Yihan Wang, Youhui Si, Dengping Yin, Christopher R Weber, Melissa L Fishel, Karen E Pollok, Bo Qiu, Fei Xiao, Anita S Chong
Publikováno v:
eLife, Vol 12 (2023)
Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, and despite advancements in disease management, the 5 -year survival rate stands at only 12%. Triptolides have potent anti-tumor activity against different types of can
Externí odkaz:
https://doaj.org/article/a0417a7ca68f4cbb9b4bc3e0f6eb02c6
Autor:
Joy Garrett, Erin Metzger, Mark W. Dewhirst, Karen E. Pollok, John J. Turchi, Isabelle C. Le Poole, Kira Couch, Logan Lew, Anthony Sinn, Jeffrey M. Zaleski, Joseph R. Dynlacht
Publikováno v:
International Journal of Hyperthermia, Vol 39, Iss 1, Pp 405-413 (2022)
Background Enediynes are anti-cancer agents that are highly cytotoxic due to their propensity for low thermal activation of radical generation. The diradical intermediate produced from Bergman cyclization of the enediyne moiety may induce DNA damage
Externí odkaz:
https://doaj.org/article/7245f922c324473d88674548fe76d2e9
Autor:
Kexin Li, Qingji Huo, Nathan H Dimmitt, Guofan Qu, Junjie Bao, Pankita H Pandya, M Reza Saadatzadeh, Khadijeh Bijangi-Vishehsaraei, Melissa A Kacena, Karen E Pollok, Chien-Chi Lin, Bai-Yan Li, Hiroki Yokota
Publikováno v:
eLife, Vol 12 (2023)
Osteosarcoma (OS) is the common primary bone cancer that affects mostly children and young adults. To augment the standard-of-care chemotherapy, we examined the possibility of protein-based therapy using mesenchymal stem cells (MSCs)-derived proteome
Externí odkaz:
https://doaj.org/article/ba8234a336c14e4ea67c0a581db5fd95
Autor:
Xiaohui Zhan, Yusong Liu, Asha Jacob Jannu, Shaoyang Huang, Bo Ye, Wei Wei, Pankita H. Pandya, Xiufen Ye, Karen E. Pollok, Jamie L. Renbarger, Kun Huang, Jie Zhang
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
BackgroundRhabdomyosarcoma (RMS) is a soft tissue sarcoma usually originated from skeletal muscle. Currently, RMS classification based on PAX–FOXO1 fusion is widely adopted. However, compared to relatively clear understanding of the tumorigenesis i
Externí odkaz:
https://doaj.org/article/79d6fc076e1c45328c77bf086a59641c
Autor:
Luke R. Jackson, Megan R. Masi, Bryce M. Selman, George E. Sandusky, Hamideh Zarrinmayeh, Sudip K. Das, Surendra Maharjan, Nian Wang, Qi-Huang Zheng, Karen E. Pollok, Scott E. Snyder, Phillip Zhe Sun, Gary D. Hutchins, Elizabeth R. Butch, Michael C. Veronesi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Many drugs that show potential in animal models of glioblastoma (GBM) fail to translate to the clinic, contributing to a paucity of new therapeutic options. In addition, animal model development often includes histologic assessment, but multiparametr
Externí odkaz:
https://doaj.org/article/dce0b57be4ec432d8870dea6dcea66e1
Autor:
Pamela S. VanderVere-Carozza, Navnath S. Gavande, Shadia I. Jalal, Karen E. Pollok, Elmira Ekinci, Joshua Heyza, Steve M. Patrick, Andi Masters, John J. Turchi, Katherine S. Pawelczak
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Replication protein A (RPA) plays essential roles in DNA replication, repair, recombination, and the DNA damage response (DDR). Retrospective analysis of lung cancer patient data demonstrates high RPA expression as a negative prognostic biomarker for
Externí odkaz:
https://doaj.org/article/1d4434aabcf24c4eb69ee21c9ff5887f
Autor:
Lijun Cheng, Pankita H. Pandya, Enze Liu, Pooja Chandra, Limei Wang, Mary E. Murray, Jacquelyn Carter, Michael Ferguson, Mohammad Reza Saadatzadeh, Khadijeh Bijangi-Visheshsaraei, Mark Marshall, Lang Li, Karen E. Pollok, Jamie L. Renbarger
Publikováno v:
BMC Medical Genomics, Vol 12, Iss S1, Pp 89-106 (2019)
Abstract Background While most pediatric sarcomas respond to front-line therapy, some bone sarcomas do not show radiographic response like soft-tissue sarcomas (rhabdomyosarccomas) but do show 90% necrosis. Though, new therapies are urgently needed t
Externí odkaz:
https://doaj.org/article/c84d516da0b2495cade50ee11486450f