Gestational Age Influences the Early Microarchitectural Changes in Response to Mechanical Ventilation in the Preterm Lamb Lung

Autor: Regina B. Oakley, David G. Tingay, Karen E. McCall, Elizabeth J. Perkins, Magdy Sourial, Peter A. Dargaville, Prue M. Pereira-Fantini

Publikováno v: Frontiers in Pediatrics, Vol 7 (2019)

Background: Preterm birth is associated with abnormal lung architecture, and a reduction in pulmonary function related to the degree of prematurity. A thorough understanding of the impact of gestational age on lung microarchitecture requires reproduc

Externí odkaz: https://doaj.org/article/073d434d3bd64377a82c3944dc2ff179

Dynamic positive end-expiratory pressure strategies using time and pressure recruitment at birth reduce early expression of lung injury in preterm lambs

Autor: David G. Tingay, Prue M. Pereira-Fantini, Martijn Miedema, Karen E. McCall, Elizabeth J. Perkins, Georgie Dowse, Nicholas Schinckel, Magdy Sourial, Peter G. Davis

Publikováno v: American Journal of Physiology. Lung Cellular and Molecular Physiology, 323(4), L464-L472. American Physiological Society
Tingay, D G, Pereira-Fantini, P M, Miedema, M, McCall, K E, Perkins, E J, Dowse, G, Schinckel, N, Sourial, M & Davis, P G 2022, ' Dynamic positive end-expiratory pressure strategies using time and pressure recruitment at birth reduce early expression of lung injury in preterm lambs ', American Journal of Physiology. Lung Cellular and Molecular Physiology, vol. 323, no. 4, pp. L464-L472 . https://doi.org/10.1152/ajplung.00047.2022

Positive end-expiratory pressure (PEEP) is critical to the preterm lung at birth, but the optimal PEEP level remains uncertain. The objective of this study was to determine the effect of maximum PEEP levels at birth on the physiological and injury re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f837068e41a85aaaba9a457313f594d
https://research.vumc.nl/en/publications/87b350c2-275a-44b5-b89a-38bd2ad17df5

Gradual aeration at birth is more lung protective than a sustained inflation in preterm lambs

Autor: Karen E. McCall, Jessica Thomson, Regina B. Oakley, Prue M. Pereira-Fantini, Elizabeth J. Perkins, Andreas D. Waldmann, Peter G Davis, Peter A. Dargaville, Raffaele Dellaca, David G. Tingay, Magdy Sourial, Martijn Miedema

Publikováno v: American journal of respiratory and critical care medicine, 200(5), 608-616. American Thoracic Society
American Journal of Respiratory and Critical Care Medicine

Rationale: The preterm lung is susceptible to injury during transition to air breathing at birth. It remains unclear whether rapid or gradual lung aeration at birth causes less lung injury. Objectives: To examine the effect of gradual and rapid aerat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b20fed72a176eb655228a3d9fcdc3752
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85068098981&origin=inward

The interrelationship of recruitment maneuver at birth, antenatal steroids, and exogenous surfactant on compliance and oxygenation in preterm lambs

Autor: Peter G Davis, Don Black, Karen E. McCall, Cornelis Elroy E. Zonneveld, Anna Lavizzari, Magdy Sourial, Anushi E Rajapaksa, Elizabeth J. Perkins, David G. Tingay

Publikováno v: Pediatric Research. 79:916-921

To describe the interrelationship between antenatal steroids, exogenous surfactant, and two approaches to lung recruitment at birth on oxygenation and respiratory system compliance (Cdyn) in preterm lambs.Lambs (n = 63; gestational age 127 ± 1 d) re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99e94263f76f1c913308f070704469fd
https://doi.org/10.1038/pr.2016.25

Plasma proteomics reveals gestational age-specific responses to mechanical ventilation and identifies the mechanistic pathways that initiate preterm lung injury

Autor: Prue M. Pereira-Fantini, Elizabeth J. Perkins, Regina B. Oakley, Karen E. McCall, Peter A. Dargaville, Vera Ignjatovic, Peter G Davis, Raffaele Dellaca, Sean G. Byars, David G. Tingay

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports

The preterm lung is particularly vulnerable to ventilator-induced lung injury (VILI) as a result of mechanical ventilation. However the developmental and pathological cellular mechanisms influencing the changing patterns of VILI have not been compreh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc75571d942a382929901f0077b25b05
https://doi.org/10.1038/s41598-018-30868-x