Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Karen E, Christensen"'
Autor:
Alaina M, Reagan, Karen E, Christensen, Leah C, Graham, Amanda A, Bedwell, Kierra, Eldridge, Rachael, Speedy, Lucas L, Figueiredo, Scott C, Persohn, Teodoro, Bottiglieri, Kwangsik, Nho, Michael, Sasner, Paul R, Territo, Rima, Rozen, Gareth R, Howell
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 42(12)
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer's disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b777dfaf3b327ed352bb333f71cdea06
https://pubmed.ncbi.nlm.nih.gov/36050860
https://pubmed.ncbi.nlm.nih.gov/36050860
Autor:
Karen E. Christensen, Olga V. Malysheva, Stephanie Carlin, Fernando Matias, Amanda J. MacFarlane, René L. Jacobs, Marie A. Caudill, Rima Rozen
Publikováno v:
Nutrients, Vol 14, Iss 1, p 127 (2021)
Folate and choline are interconnected metabolically. The MTHFD1 R653Q SNP is a risk factor for birth defects and there are concerns that choline deficiency may interact with this SNP and exacerbate health risks. 80–90% of women do not meet the Adeq
Externí odkaz:
https://doaj.org/article/22bf2917fcf54b0bbfe976a0061fea9e
Autor:
Alaina M Reagan, Karen E Christensen, Leah C Graham, Amanda A Bedwell, Kierra Eldridge, Rachael Speedy, Lucas L Figueiredo, Scott C Persohn, Teodoro Bottiglieri, Kwangsik Nho, Michael Sasner, Paul R Territo, Rima Rozen, Gareth R Howell
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:2333-2350
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer’s disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7482d7ee3029e817139cb404a3264cea
https://doi.org/10.1177/0271678x221122644
https://doi.org/10.1177/0271678x221122644
Autor:
Marta Cosín-Tomás, Yan Luan, Daniel Leclerc, Olga V. Malysheva, Nidia Lauzon, Renata H. Bahous, Karen E. Christensen, Marie A. Caudill, Rima Rozen
Publikováno v:
Nutrients, Vol 12, Iss 6, p 1716 (2020)
Fifteen to 20% of pregnant women may exceed the recommended intake of folic acid (FA) by more than four-fold. This excess could compromise neurocognitive and motor development in offspring. Here, we explored the impact of an FA-supplemented diet (5×
Externí odkaz:
https://doaj.org/article/031657503cd645c69bbbe426c1628c7b
Autor:
Alaina M. Reagan, Karen E. Christensen, Leah C. Graham, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, Lucas L. Figueiredo, Scott C. Persohn, Teodoro Bottiglieri, Michael Sasner, Paul R. Territo, Rima Rozen, Gareth R. Howell
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer’s disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a495d9decd9314e5a8bd0cf4d7825317
https://doi.org/10.1101/2021.12.16.472805
https://doi.org/10.1101/2021.12.16.472805
Autor:
Gareth R. Howell, Annat Haber, Karen E. Christensen, Gregory W. Carter, Alaina M. Reagan, Michael Sasner, Rima Rozen
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b2c1b3f58c4d7736c975525192bd1f4
https://doi.org/10.1002/alz.038657
https://doi.org/10.1002/alz.038657
Publikováno v:
The Journal of nutritional biochemistry. 88
Food fortification with folic acid and increased use of vitamin supplements have raised concerns about high folic acid intake. We previously showed that high folic acid intake was associated with hepatic degeneration, decreased levels of methylenetet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acb21f3c793d20f95a8804accb37f4be
https://pubmed.ncbi.nlm.nih.gov/33220403
https://pubmed.ncbi.nlm.nih.gov/33220403
Autor:
D. Sean Froese, Gawa Bidla, Jean-Louis Guéant, Brian M. Gilfix, Avi Saskin, David S. Rosenblatt, Courtney Ells, Matin Kerachian, Karen E. Christensen, David Watkins, Céline Chéry
Publikováno v:
Molecular genetics and metabolism. 130(3)
MTHFD1 is a trifunctional protein containing 10-formyltetrahydrofolate synthetase, 5,10-methenyltetrahydrofolate cyclohydrolase and 5,10-methylenetetrahydrofolate dehydrogenase activities. It is encoded by MTHFD1 and functions in the cytoplasmic fola
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f377896eee8f8ad4f740bc0c7140adc5
https://pubmed.ncbi.nlm.nih.gov/32414565
https://pubmed.ncbi.nlm.nih.gov/32414565
Autor:
Erland Arning, Karen E. Christensen, Olga V. Malysheva, Renata H. Bahous, Wenyang Hou, Marie A. Caudill, Liyuan Deng, Rima Rozen, Teodoro Bottiglieri, Loydie A. Jerome-Majewska
Publikováno v:
The Journal of Nutrition. 148:501-509
Background Suboptimal folate intake, a risk factor for birth defects, is common even in areas with folate fortification. A polymorphism in methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), R653Q (MTHFD1 c.1958 G > A), has also been associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f95e7335cec11f55ef644bb9e2076cfb
https://doi.org/10.1093/jn/nxy013
https://doi.org/10.1093/jn/nxy013
Autor:
Nidia Lauzon, Karen E. Christensen, Olga V. Malysheva, Renata H. Bahous, Marta Cosín-Tomás, Marie A. Caudill, Yan Luan, Rima Rozen, Daniel Leclerc
Publikováno v:
Nutrients, Vol 12, Iss 1716, p 1716 (2020)
Nutrients
Volume 12
Issue 6
Nutrients
Volume 12
Issue 6
Fifteen to 20% of pregnant women may exceed the recommended intake of folic acid (FA) by more than four-fold. This excess could compromise neurocognitive and motor development in offspring. Here, we explored the impact of an FA-supplemented diet (5&t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d5bef8534a7cba3de799d41b2a42db
https://doi.org/10.3390/nu12061716
https://doi.org/10.3390/nu12061716