Zobrazeno 1 - 10
of 232
pro vyhledávání: '"Karen Duff"'
Autor:
Sang Ryong Kim, Vincent Ries, Hsiao-Chun Cheng, Tatyana Kareva, Tinmarla F. Oo, W. Haung Yu, Karen Duff, Nikolai Kholodilov, Robert E. Burke
Publikováno v:
Neurobiology of Disease, Vol 44, Iss 2, Pp 215-222 (2011)
The mechanisms underlying the chronic neurodegeneration that occurs in Parkinson's disease (PD) are unknown. One emerging hypothesis is that neural systems deteriorate and eventually degenerate due to a primary failure of either extrinsic neurotrophi
Externí odkaz:
https://doaj.org/article/8cd59f1f030f417397036445fce9ad39
Autor:
Li Liu, Ian J. Orozco, Emmanuel Planel, Yi Wen, Alexis Bretteville, Pavan Krishnamurthy, Lili Wang, Mathieu Herman, Helen Figueroa, W. Haung Yu, Ottavio Arancio, Karen Duff
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 1, Pp 46-57 (2008)
In the last decade, multiple lines of transgenic APP overexpressing mice have been created that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the previously reported transgenic APP overexpressing rat models developed AD-l
Externí odkaz:
https://doaj.org/article/176eaee9e6aa4b5a841142b79871d76d
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 4, Pp 555-567 (2001)
The permeability of albumin, insulin, and human Aβ 1–40 at the blood–brain barrier (BBB) was determined in the normal adult mouse (B6/SJL) and in the double transgenic Alzheimer mouse (APP, PS1) by using an I.V. bolus injection technique to quan
Externí odkaz:
https://doaj.org/article/5fa2caa70a204de2a90de989dbe086bd
Autor:
Yasuji Matsuoka, Miquel Vila, Sarah Lincoln, Alison McCormack, Melanie Picciano, John LaFrancois, Xin Yu, Dennis Dickson, William J. Langston, Eileen McGowan, Matt Farrer, John Hardy, Karen Duff, Serge Przedborski, Donato A. Di Monte
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 3, Pp 535-539 (2001)
α-Synuclein has been identified as a major component of Lewy body inclusions, which are one of the pathologic hallmarks of idiopathic Parkinson's disease. Mutations in α-synuclein have been found to be responsible for rare familial cases of Parkins
Externí odkaz:
https://doaj.org/article/8e2813da0f1045a4bb948bd73bb938d0
Autor:
Lorenzo M. Refolo, Miguel A. Pappolla, Brian Malester, John LaFrancois, Tara Bryant-Thomas, Rong Wang, G.Stephen Tint, Kumar Sambamurti, Karen Duff
Publikováno v:
Neurobiology of Disease, Vol 7, Iss 4, Pp 321-331 (2000)
Recent data suggest that cholesterol metabolism is linked to susceptibility to Alzheimer's disease (AD). However, no direct evidence has been reported linking cholesterol metabolism and the pathogenesis of AD. To test the hypothesis that amyloid β-p
Externí odkaz:
https://doaj.org/article/63c83aa9944e4c6aa4e4629a93bf4f54
Autor:
Paul A. Barrow, Ruth M. Empson, Simon J. Gladwell, Caroline M. Anderson, Richard Killick, Xin Yu, John G.R. Jefferys, Karen Duff
Publikováno v:
Neurobiology of Disease, Vol 7, Iss 2, Pp 119-126 (2000)
Mutations in the presenilin-1 (PS1) gene cause approximately 50% of cases of early onset familial Alzheimer's disease. The function of this protein remains unknown. We have made an electrophysiological study of hippocampal slices from transgenic mice
Externí odkaz:
https://doaj.org/article/37bf0ed033834623a94554f796260b3a
Autor:
Li Liu, Valerie Drouet, Jessica W Wu, Menno P Witter, Scott A Small, Catherine Clelland, Karen Duff
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31302 (2012)
Tauopathy in the brain of patients with Alzheimer's disease starts in the entorhinal cortex (EC) and spreads anatomically in a defined pattern. To test whether pathology initiating in the EC spreads through the brain along synaptically connected circ
Externí odkaz:
https://doaj.org/article/c3290960259e4ec9a3089042ea462901
Autor:
William J Netzer, Craig Powell, Yi Nong, Jacqueline Blundell, Lili Wong, Karen Duff, Marc Flajolet, Paul Greengard
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10943 (2010)
beta-amyloid levels are elevated in Down syndrome (DS) patients throughout life and are believed to cause Alzheimer's disease (AD) in adult members of this population. However, it is not known if beta-amyloid contributes to intellectual disability in
Externí odkaz:
https://doaj.org/article/4220ca82a5624c5c9a26db686f44859e
Autor:
Connor Langworth-Green, Saisha Patel, Zane Jaunmuktane, Edwin Jabbari, Huw Morris, Maria Thom, Andrew Lees, John Hardy, Michael Zandi, Karen Duff
Publikováno v:
The Lancet Neurology. 22:430-442
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dfe08df0092b280a9b3c688ed258d6e1
https://doi.org/10.1016/s1474-4422(23)00038-8
https://doi.org/10.1016/s1474-4422(23)00038-8
Autor:
Rishi R. Agrawal, Kathleen Shannon, Ernest Fraenkel, Steven S. Gross, David N. Guilfoyle, Helen Y. Figueroa, Allissa Dillman, Karen Duff, Archana Ashok, Tal Nuriel, Estela Area-Gomez, Marta Pera, Hirra A. Arain, Qiuying Chen, Mark R. Cookson, Leila Pirhaji, Delfina Larrea
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-20 (2020)
Scientific Reports
Scientific Reports
The ε4 allele of apolipoprotein E (APOE) is the dominant genetic risk factor for late-onset Alzheimer’s disease (AD). However, the reason for the association between APOE4 and AD remains unclear. While much of the research has focused on the abili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45568ad65135cb2eadd210e151d3591f
http://link.springer.com/article/10.1038/s41598-020-61142-8
http://link.springer.com/article/10.1038/s41598-020-61142-8