Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Karen DiLoreto"'
Autor:
Shannon Dallas, Thomas Wilde, Avijit Ghosh, Jianyao Wang, Yawei Dong, Gaochao Tian, Daohong Liao, Xueliang Li, Lawrence Szewczuk, Peter King, David C. Evans, Yifan Shi, Kurtis E. Bachman, Javier Suarez, Beth Pietrak, James P. Edwards, Carlo Sensenhauser, Hao Chen, Vineet Pande, Peter J. Connolly, Karen DiLoreto, William G Bonnette, Shefali Patel, Zhuming Zhang
Publikováno v:
Journal of Medicinal Chemistry. 64:11570-11596
Selective cyclooxygenase (COX)-2 inhibitors have been extensively studied for colorectal cancer (CRC) chemoprevention. Celecoxib has been reported to reduce the incidence of colorectal adenomas and CRC but is also associated with an increased risk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b02dbb581a1a9ad484e13ee726c09b
https://doi.org/10.1021/acs.jmedchem.1c00890
https://doi.org/10.1021/acs.jmedchem.1c00890
Autor:
Fuyong Du, Brian C. Shook, Karen DiLoreto, Guozhang Xu, Fengbin Song, Yin Liang, Michael David Gaul, Rosie Santulli, Dennis Rentzeperis, Annette Eckardt, Keith T. Demarest, Renee L. DesJarlais
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(20)
Type 2 diabetes mellitus (T2DM) is characterized by chronically elevated plasma glucose levels. The inhibition of glucagon-induced hepatic glucose output via antagonism of the glucagon receptor (GCGR) using a small-molecule antagonist is a promising
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b30b8f1be120fa7a91abbdd01da299a
https://pubmed.ncbi.nlm.nih.gov/31519374
https://pubmed.ncbi.nlm.nih.gov/31519374
Autor:
Norman D. Huebert, Zhang Rui, Rosie Santulli, Annette Eckardt, Karen DiLoreto, Michael David Gaul, Fengbin Song, Guozhang Xu, Zhao Bao-Ping, Renee L. DesJarlais, Brian C. Shook, Keith T. Demarest, Tianbao Lu, Dennis Rentzeperis
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(15)
A novel series of indazole/indole derivatives were discovered as glucagon receptor (GCGR) antagonists through scaffold hopping based on two literature leads: MK-0893 and LY-2409021. Further structure-activity relationship (SAR) exploration and optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::170801b02772370463fdfb74991104c7
https://pubmed.ncbi.nlm.nih.gov/31138472
https://pubmed.ncbi.nlm.nih.gov/31138472
Autor:
Jeremy M. Travins, Carl Crysler, Hufnagel Heather Rae, Karen DiLoreto, Norman Huebert, Michael X. Kolpak, Nalin L. Subasinghe, Jennifer Kirkpatrick, Stephen H. Eisennagel, Bruce E. Tomczuk, Wenxi Pan, Christopher J. Molloy, Ehab Khalil, Nisha S. Ninan, Shelley K. Ballentine, Kristi A. Leonard, Roger F. Bone, Richard Soll, Farah Ali, Michael D. Gaul
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:5303-5307
Complement C1s protease inhibitors have potential utility in the treatment of diseases associated with activation of the classical complement pathway such as humorally mediated graft rejection, ischemia-reperfusion injury (IRI), vascular leak syndrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44891a19d07c75d5617cf44b0ba3e337
https://doi.org/10.1016/j.bmcl.2012.06.030
https://doi.org/10.1016/j.bmcl.2012.06.030
Autor:
Anja Rode, Xiaoyan Chu, Esaie Pierre, Thomas Wanek, Jeevan Kunta, Mario Mezler, Clara Andonian, Jocelyn Yabut, Jodie Pang, Carolin Hoft, Stéphanie Chasseigneaux, Shannon Dallas, Oliver Langer, Xiaolin Zhang, Damir Simic, David Gomez-Zepeda, Karen DiLoreto, Liangfu Chen, Loic Laplanche, Tony Pereira, Marie-Claude Menet, Laurent Salphati, Nico Scheer, Xavier Declèves
Publikováno v:
Molecular pharmacology. 89(5)
Breast cancer resistance protein (BCRP) is expressed in various tissues, such as the gut, liver, kidney and blood brain barrier (BBB), where it mediates the unidirectional transport of substrates to the apical/luminal side of polarized cells. Thereby
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0f3f7f274bf64d012abb659bb9c9f6
https://pubmed.ncbi.nlm.nih.gov/26893303
https://pubmed.ncbi.nlm.nih.gov/26893303
Autor:
Dennis Kalamaridis, Karen DiLoreto
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781627037419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69b5e4776d87fe34a10156eded844328
https://doi.org/10.1007/978-1-62703-742-6_3
https://doi.org/10.1007/978-1-62703-742-6_3
