Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Karen Daugherty"'
Autor:
Benjamin A Smith, Shae B Padrick, Lynda K Doolittle, Karen Daugherty-Clarke, Ivan R Corrêa Jr, Ming-Qun Xu, Bruce L Goode, Michael K Rosen, Jeff Gelles
Publikováno v:
eLife, Vol 2 (2013)
During cell locomotion and endocytosis, membrane-tethered WASP proteins stimulate actin filament nucleation by the Arp2/3 complex. This process generates highly branched arrays of filaments that grow toward the membrane to which they are tethered, a
Externí odkaz:
https://doaj.org/article/101ba6f4735146f682e1059f11779d6f
Publikováno v:
Proceedings of the National Academy of Sciences. 110:1285-1290
Actin filament nucleation by actin-related protein (Arp) 2/3 complex is a critical process in cell motility and endocytosis, yet key aspects of its mechanism are unknown due to a lack of real-time observations of Arp2/3 complex through the nucleation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a829ceee59599cd4d5cfd42a8a6fd77
https://doi.org/10.1073/pnas.1211164110
https://doi.org/10.1073/pnas.1211164110
Publikováno v:
Journal of Biological Chemistry. 285:8481-8491
The Arp2/3 complex is a conserved seven-subunit actin-nucleating machine activated by WASp (Wiskott Aldrich syndrome protein). Despite its central importance in a broad range of cellular processes, many critical aspects of the mechanism of the Arp2/3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c93f3e8b16011efb68861624131249
https://doi.org/10.1074/jbc.m109.054957
https://doi.org/10.1074/jbc.m109.054957
Autor:
Lynda K. Doolittle, Shae B. Padrick, Ivan R. Corrêa, Michael K. Rosen, Karen Daugherty-Clarke, Jeff Gelles, Benjamin Smith, Ming Qun Xu, Bruce L. Goode
Publikováno v:
eLife, Vol 2 (2013)
eLife
eLife
During cell locomotion and endocytosis, membrane-tethered WASP proteins stimulate actin filament nucleation by the Arp2/3 complex. This process generates highly branched arrays of filaments that grow toward the membrane to which they are tethered, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::916990601d5f93c9057babd638666e09
https://elifesciences.org/articles/01008
https://elifesciences.org/articles/01008
Autor:
Irwin H. Krakoff, Karen Daugherty, Martin N. Raber, Dah Hsi Ho, William T. Bradner, Richard Pazdur
Publikováno v:
Investigational New Drugs. 9:377-382
FK973 is a novel, substituted dihydrobenzoxazine structurally similar to mitomycin. FK973 lacks cross-resistance with mitomycin, doxorubicin, and vincristine in murine tumor models. A phase I study of FK973 was initiated using a 30-minute infusion re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::939380b04063d80d600f932664af0315
https://doi.org/10.1007/bf00183587
https://doi.org/10.1007/bf00183587
Autor:
Karen Daugherty-Clarke, Bruce L. Goode
Publikováno v:
Developmental cell. 15(3)
EspF U , a protein secreted by pathogenic enterohaemorrhagic E. coli (EHEC), activates N-WASp/WASp to induce actin pedestal formation in host cells. Two recent papers in Nature show that EspF U exploits a WASp activation strategy so extreme that it m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0275bb65b9dfcb2104bed7a5a68dde99
https://pubmed.ncbi.nlm.nih.gov/18804428
https://pubmed.ncbi.nlm.nih.gov/18804428
Publikováno v:
JNCI Journal of the National Cancer Institute. 86:51-53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac1d3b609b365947d9485f5d119dfad
https://doi.org/10.1093/jnci/86.1.51
https://doi.org/10.1093/jnci/86.1.51
Publikováno v:
Investigational New Drugs. 11:67-69
Based on encouraging in vitro and in vivo data, 14 consecutive patients with measurable metastatic previously untreated colorectal carcinoma were treated with a combination of intravenous etoposide and subcutaneous alpha-interferon. Etoposide was giv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690cdaa2fd26462177479ef175fd159f
https://doi.org/10.1007/bf00873914
https://doi.org/10.1007/bf00873914
Autor:
Jaffer A. Ajani, Roxann Blackburn, James L. Abbruzzese, Yehuda Z. Patt, Dennie V. Jones, Bernard Levin, Karen Daugherty
Publikováno v:
Investigational New Drugs. 10:211-213
Didemnin B is a depsipeptide derived from a Caribbean tunicate (sea squirt) that has demonstrated antineoplastic activity against a variety of murine tumor models, including the L1210 and P388 leukemia, the B16 melanoma, and M5076 sarcoma cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bced6de05ca8b1db531c9967958a46
https://doi.org/10.1007/bf00877248
https://doi.org/10.1007/bf00877248
Autor:
David H. Ilson, Patrick M. Lynch, Richard Pazdur, David P. Kelsen, Jaffer A. Ajani, Karen Daugherty
Publikováno v:
Journal of the National Cancer Institute. 86(14)
BACKGROUND Carcinomas of the esophagus and gastroesophageal junction are uncommon and account for approximately 1% of all malignancies in the United States. Advanced squamous cell carcinoma or adenocarcinoma of these sites remains incurable. The medi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f899f957422991530a78861d507e385
https://pubmed.ncbi.nlm.nih.gov/7912736
https://pubmed.ncbi.nlm.nih.gov/7912736