Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Karen D McCloskey"'
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0193923 (2018)
Radiation-induced bladder toxicity is associated with radiation therapy for pelvic malignancies, arising from unavoidable irradiation of neighbouring normal bladder tissue. This study aimed to investigate the acute impact of ionizing radiation on the
Externí odkaz:
https://doaj.org/article/7475b03f28d54e9794d01d86744d95a2
Publikováno v:
Continence, Vol 10, Iss , Pp 101223- (2024)
The external urethral sphincter (EUS), composed of skeletal muscle, along with a smooth muscle-lined internal urethral sphincter (IUS), have crucial roles in maintaining continence during bladder filling and facilitating urine flow during voiding. Di
Externí odkaz:
https://doaj.org/article/0ac897f0276f460ba515539b3eec48fb
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53423 (2013)
Several populations of interstitial cells of Cajal (ICC) exist in the bladder, associated with intramural nerves. Although ICC respond to exogenous agonists, there is currently no evidence of their functional innervation. The objective was to determi
Externí odkaz:
https://doaj.org/article/c31b50e73f774a0a98e42773744c694e
Autor:
Niamh McKerr, Adone Mohd-Sarip, Hannah Dorrian, Conor Breen, Jacqueline A. James, Stephen McQuaid, Ian G. Mills, Karen D. McCloskey
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)
Abstract Prostate cancer is often treated by perturbing androgen receptor signalling. CACNA1D, encoding CaV1.3 ion channels is upregulated in prostate cancer. Here we show how hormone therapy affects CACNA1D expression and CaV1.3 function. Human pros
Externí odkaz:
https://doaj.org/article/8aae43c94ec84d0282f547ff3e22e3c2
Autor:
Vincenzo Barrese, Zena Wehbe, Alice Linden, Sarah McDowell, Elizabeth Forrester, Oleksander Povstyan, Karen D. McCloskey, Iain A. Greenwood
Publikováno v:
Physiological Reports, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract In addition, to their established role in cardiac myocytes and neurons, ion channels encoded by ether‐a‐go‐go‐related genes (ERG1‐3 or kcnh2,3 and 6) (kcnh2) are functionally relevant in phasic smooth muscle. The aim of the study w
Externí odkaz:
https://doaj.org/article/957e9568d5be40668d33d9da2ecdf533
Autor:
Celine Grenier, Filipa M. Lopes, Anna M. Cueto-González, Eulàlia Rovira-Moreno, Romy Gander, Benjamin W. Jarvis, Karen D. McCloskey, Alison M. Gurney, Glenda M. Beaman, William G. Newman, Adrian S. Woolf, Neil A. Roberts
Publikováno v:
Kidney International Reports.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e99cac17e249141bcf70ee1b164f9bc
https://doi.org/10.1016/j.ekir.2023.04.017
https://doi.org/10.1016/j.ekir.2023.04.017
Autor:
Celine Grenier, Filipa M. Lopes, Anna M Cueto-González, Eulàlia Rovira-Moreno, Romy Gander, Benjamin W Jarvis, Karen D. McCloskey, Alison M. Gurney, Glenda M. Beaman, William G. Newman, Adrian S. Woolf, Neil A. Roberts
Urinary tract malformations account for half of all children with kidney failure, and some have defined monogenic causes. One such disorder is urofacial, or Ochoa, syndrome (UFS), an autosomal recessive disease featuring a dyssynergic bladder with de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35e49d20332dfbc5e75ea504b3170f62
https://doi.org/10.1101/2022.12.06.22283097
https://doi.org/10.1101/2022.12.06.22283097
Autor:
Christopher H. Fry, Karen D. McCloskey
Publikováno v:
Fry, C H & McCloskey, K D 2021, ' Purinergic signalling in the urinary bladder : When function becomes dysfunction ', Autonomic Neuroscience: Basic and Clinical, vol. 235, 102852 . https://doi.org/10.1016/j.autneu.2021.102852
Auton Neurosci
Auton Neurosci
Knowledge of the participation of ATP and related purines in urinary tract physiology has been established over the last five decades through the work of many independent groups, inspired by, and building on the pioneering studies of Professor Geoffr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ee542cf4d239aaf62b75c0f66e8678
https://hdl.handle.net/1983/bd9b32b2-9f5b-4da2-81ab-90a28fe301d4
https://hdl.handle.net/1983/bd9b32b2-9f5b-4da2-81ab-90a28fe301d4
Publikováno v:
Manak, I, Gurney, A M, McCloskey, K D, Woolf, A S & Roberts, N A 2020, ' Dysfunctional bladder neurophysiology in urofacial syndrome Hpse2 mutant mice ', Neurourology and Urodynamics, vol. 39, no. 7, pp. 1930-1938 . https://doi.org/10.1002/nau.24450
Manak, I, Gurney, A, McCloskey, K D, Woolf, A S & Roberts, N 2020, ' Dysfunctional bladder neurophysiology in urofacial syndrome Hpse2 mutant mice ', Neurourology and Urodynamics, vol. 39, no. 7, pp. 1930-1938 . https://doi.org/10.1002/nau.24450
Manak, I, Gurney, A, McCloskey, K D, Woolf, A S & Roberts, N 2020, ' Dysfunctional bladder neurophysiology in urofacial syndrome Hpse2 mutant mice ', Neurourology and Urodynamics, vol. 39, no. 7, pp. 1930-1938 . https://doi.org/10.1002/nau.24450
Aims: Urofacial syndrome (UFS) is an autosomal recessive disease characterized by detrusor contraction against an incompletely dilated outflow tract. This dyssynergia causes dribbling incontinence and incomplete voiding. Around half of individuals wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0eb24a5ae6835f609ecdbc14da2f576
https://pubmed.ncbi.nlm.nih.gov/32609936
https://pubmed.ncbi.nlm.nih.gov/32609936
Autor:
Tufan Tarcan, Karl-Erik Andersson, Karen D. McCloskey, John E. Speich, Alan J. Wein, Bahareh Vahabi, Hikaru Hashitani, Lori A. Birder
Publikováno v:
Neurourol Urodyn
Several studies indicate that pelvic ischemia and oxidative stress may play a significant role in lower urinary tract dysfunction (LUTD), including detrusor overactivity (DO)/overactive bladder (OAB) and detrusor underactivity (DU)/underactive bladde
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76b2a86026054953d1d5887d69a7853
https://doi.org/10.1002/nau.24313
https://doi.org/10.1002/nau.24313