Zobrazeno 1 - 10 of 16 pro vyhledávání: '"Karen Clegg"'
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Abstract CT136: An open-label phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination in patients with advanced hematological malignancies
Autor: Tomasz Knurowski, Emma Searle, Karen Clegg, Neil Pegg, William West, Debbie Haynes, Kristopher Frese, Tim C. Somervaille
Publikováno v: Cancer Research. 83:CT136-CT136
Background Inobrodib (CCS1477) is a first in class potent, selective, and orally bioavailable inhibitor of the bromodomains of p300 and CBP, two closely related histone acetyl transferases with oncogenic roles in hematological malignancies. In pre-cl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::967621c9037f393099702a80509d632b
https://doi.org/10.1158/1538-7445.am2023-ct136
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5
Elektronická kniha
Doctoral Supervision and Research Culture : What We Know, What Works and Why
Autor: Karen Clegg, Gillian Houston, Owen Gower
Drawing on original survey data, reflective accounts, and case studies of supervisory practice in different disciplines, Doctoral Supervision and Research Culture explores the supervisor experience and demonstrates the craft, compassion and consisten
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6
Towards a framework for the recognition of good supervisory practice
Autor: Karen Clegg, Stan Taylor
Publikováno v: The Future of Doctoral Research ISBN: 9781003015383
Historically, it was assumed that the only requirement to be a research supervisor was to be research-active. If this was ever true, it is not today in view of recent seismic changes which have transformed the roles of supervisors. The latter have ha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e02eae615ed8f0189c01e580c5178d8c
https://doi.org/10.4324/9781003015383-24
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7
CCS1477, a Novel p300/CBP Bromodomain Inhibitor, Enhances Efficacy of Azacitidine and Venetoclax in Pre-Clinical Models of Acute Myeloid Leukaemia and Lymphoma
Autor: Gary J. Spencer, Karen Clegg, Andrew Hughes, Tim C. P. Somervaille, John A. Chadwick, William H. West, Nigel Brooks, Tomasz Knurowski, Neil Anthony Pegg
Publikováno v: Blood. 138:3291-3291
E1A binding protein (p300) and CREB binding protein (CBP) are two closely related histone acetyl transferases that co-activate key oncogenes such as MYC and IRF4 which are relevant in a number of haematological malignancies. Here we describe the effe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::895261a272175d42b978a038bff92d5b
https://doi.org/10.1182/blood-2021-148295
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10
Developing the next generation of academics
Autor: Karen Clegg, Giles Martin
Publikováno v: Innovative Assessment in Higher Education ISBN: 9780429506857
Innovative Assessment in Higher Education
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dba021e7c5cd6b81778364b47512c47
https://doi.org/10.4324/9780429506857-19
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