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Publikováno v:
Analytica Chimica Acta. 929:31-38
Gangliosides are found in abundance in the central nervous system of vertebrates. Their metabolic disruption and dysfunction are associated with various neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. In order to impr
Autor:
Angela Rowan, Karen Cechner, Baozhong Xin, Max Wiznitzer, Qianyang Huang, Andi Wang, Paul McJarrow, Danting Liu, Julia Szekely, Heng Wang, Valerie Sency, Aimin Zhou, Alicia Bright, JoAnn Brace
Publikováno v:
JIMD Reports ISBN: 9783662586464
Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides. GM3 synthase deficiency (GM3D) causes an absence of GM3 and all downstream biosynthetic derivatives. The affected individuals manifest with severe irritability, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621b332bd4d8c76576f3909b510df700
https://doi.org/10.1007/8904_2018_134
https://doi.org/10.1007/8904_2018_134
Publikováno v:
Analytical biochemistry. 455
Gangliosides are a family of glycosphingolipids characterized by mono- or polysialic acid-containing oligosaccharides linked through 1,3- and 1,4-β glycosidic bonds with subtle differences in structure that are abundantly present in the central nerv