Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karen C. Morrison"'
Total Synthesis, Stereochemical Assignment, and Biological Activity of All Known (−)-Trigonoliimines
Publikováno v:
The Journal of Organic Chemistry. 79:473-486
A full account of our concise and enantioselective total syntheses of all known (-)-trigonoliimine alkaloids is described. Our retrobiosynthetic analysis of these natural products enabled identification of a single bistryptamine precursor as a precur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea55163f8cc595e54f0c5002931f4a1
https://doi.org/10.1021/jo4020358
https://doi.org/10.1021/jo4020358
Autor:
Timothy A. Flood, Robert W. Huigens, Karen C. Morrison, Paul J. Hergenrother, Robert W. Hicklin, Michelle F. Richter
Publikováno v:
Nature Chemistry. 5:195-202
High-throughput screening is the dominant method used to identify lead compounds in drug discovery. As such, the makeup of screening libraries largely dictates the biological targets that can be modulated and the therapeutics that can be developed. U
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785225f6e1c8a3963f28899e03a07c9d
https://doi.org/10.1038/nchem.1549
https://doi.org/10.1038/nchem.1549
Publikováno v:
Analytical Biochemistry. 420:26-32
Perturbation of the tubulin/microtubule dynamic in cells is perhaps the single most important mode of action of anticancer drugs. Standard methods for identifying and evaluating compounds for their ability to alter tubulin polymerization are low thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a067f22ca8fd4a80b4c2d7ede42c2a7
https://doi.org/10.1016/j.ab.2011.08.020
https://doi.org/10.1016/j.ab.2011.08.020
Autor:
Perry Kennedy, Said M. Sebti, Karen C. Morrison, Paul J. Hergenrother, Liwei Chen, rajanikanth vangipurapu
Publikováno v:
Cancer Research. 78:1669-1669
Mutant KRas is a major driver of human cancer, yet currently no clinically approved therapies that directly target mutant KRas are available. In order to identify novel drugs that bind either mutant KRas or its effector Raf-1, we used alpha-screen an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d9f5f52a6460dbe849b32c355e1808
https://doi.org/10.1158/1538-7445.am2018-1669
https://doi.org/10.1158/1538-7445.am2018-1669
Publikováno v:
ChemInform. 45
Full details of the enantioselective total syntheses of all known (-)-trigonoliimine alkaloids already shortly reported in 2011 (see CI 2011-50-182) are given that had enabled the revision of the absolute stereochemistry of trigonoliimine A (Ia), B (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ca63fc77ec2a43943e5f1a66d08d0e
https://doi.org/10.1002/chin.201426200
https://doi.org/10.1002/chin.201426200
The full details for our enantioselective total syntheses of (−)-agelastatins A–F (1–6), the evolution of a new methodology for synthesis of substituted azaheterocycles, and the first side-by-side evaluation of all known (−)-agelastatin alkal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5dbfd33a8276e42c63ee7e27a4e1e7e
https://europepmc.org/articles/PMC3920459/
https://europepmc.org/articles/PMC3920459/
Publikováno v:
Natural product reports. 31(1)
Covering: up to 2013 Natural products and their derivatives are used as treatments for numerous diseases. Many of these compounds are structurally complex, possessing a high percentage of sp3 hybridized carbons and multiple stereogenic centers. Due t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8abfef427adad595b04b95719377b6f4
https://pubmed.ncbi.nlm.nih.gov/24219884
https://pubmed.ncbi.nlm.nih.gov/24219884
Publikováno v:
PMC
The epipolythiodiketopiperazine (ETP) alkaloids are a highly complex class of natural products with potent anticancer activity. Herein, we report the application of a flexible and scalable synthesis, allowing the construction of dozens of ETP derivat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56755417a0539d5e53f56920820f7b25
https://pubmed.ncbi.nlm.nih.gov/23914293
https://pubmed.ncbi.nlm.nih.gov/23914293
Autor:
Stephen T. Reeders, Milton E. Noelken, Mariko Mariyama, Kurt E. Ebner, Billy G. Hudson, Raghuram Kalluri, Karen C. Morrison, Sripad Gunwar
Publikováno v:
Journal of Biological Chemistry. 266:24018-24024
The autoantibodies of patients with Goodpasture syndrome are primarily targeted to the noncollagenous (NC1) domain of the alpha 3(IV) chain of basement membrane collagen (Saus, J., Wieslander, J., Langeveld, J. P. M., Quinones, S., and Hudson, B. G.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6214402a5620fa40cdd92f9d0c42ed58
https://doi.org/10.1016/s0021-9258(18)54385-4
https://doi.org/10.1016/s0021-9258(18)54385-4
Publikováno v:
Organic Letters. 11:2217-2218
A concise, biomimetic synthesis of the antifungal and antispasmodic natural product (+)-davanone is described. The key stereoselective reactions are a Sharpless asymmetric epoxidation, a thiazolium-catalyzed esterification, and a palladium-mediated c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce09dde8c7601b72fa3d5654496e9bb1
https://doi.org/10.1021/ol900697w
https://doi.org/10.1021/ol900697w