Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Karen C. Holdridge"'
Autor:
Andrew J. Aschenbrenner, Jason Hassenstab, Guoqiao Wang, Yan Li, Chengjie Xiong, Eric McDade, David B. Clifford, Stephen Salloway, Martin Farlow, Roy Yaari, Eden Y. J. Cheng, Karen C. Holdridge, Catherine J. Mummery, Colin L. Masters, Ging-Yuek Hsiung, Ghulam Surti, Gregory S. Day, Sandra Weintraub, Lawrence S. Honig, James E. Galvin, John M. Ringman, William S. Brooks, Nick C. Fox, Peter J. Snyder, Kazushi Suzuki, Hiroyuki Shimada, Susanne Gräber, Randall J. Bateman
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Demonstrating a slowing in the rate of cognitive decline is a common outcome measure in clinical trials in Alzheimer’s disease (AD). Selection of cognitive endpoints typically includes modeling candidate outcome measures in the many, richly phenoty
Externí odkaz:
https://doaj.org/article/729c320574be4f4a868a3bad97db96d9
Autor:
Diana Otero Svaldi, Ixavier A. Higgins, Karen C. Holdridge, Roy Yaari, Michael Case, Luc Bracoud, David Scott, Sergey Shcherbinin, John R. Sims
Publikováno v:
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, Vol 8, Iss 1, Pp n/a-n/a (2022)
Abstract Introduction Solanezumab is a monoclonal antibody that preferentially binds soluble amyloid beta and promotes its clearance from the brain. The aim of this post hoc analysis was to assess the effect of low‐dose solanezumab (400 mg) on glob
Externí odkaz:
https://doaj.org/article/c88699e26d684a68be60ce2fde940679
Publikováno v:
Alzheimer's & Dementia.
Autor:
Christopher H. van Dyck, Roger Clarnette, Susan Mills, John C. Morris, Carlos Cruchaga, Anna Santacruz, Ging-Yuek Robin Hsiung, Roy Yaari, Suman Jayadev, Caroline Giacobino, William S. Brooks, Robert A. Koeppe, Raquel Sánchez-Valle, Anne M. Fagan, Eric McDade, Sarah B. Berman, Catherine J. Mummery, Florence Pasquier, Scott M. Berry, Randall J. Bateman, Brian A. Gordon, Jorge J. Llibre-Guerra, Maïté Formaglio, Paul S. Aisen, Paulo Fontoura, Mark A. Mintun, Bruno Dubois, Erik D. Roberson, Kelley Coalier, Ronald G. Thomas, Martin R. Farlow, John R. Sims, Serge Gauthier, Douglas Galasko, Mario Masellis, G. Mustafa Surti, Barbara A. Wendelberger, Guoqiao Wang, James J. Lah, Yan Li, David B. Clifford, David Wallon, Paul Delmar, Alison Goate, Rachelle S. Doody, Didier Hannequin, Stephen Salloway, Geoffrey A. Kerchner, Karen C. Holdridge, Ivonne Z. Jimenez-Velazquez, Janice M. Hitchcock, Monika Baudler, Lawrence S. Honig, Tammie L.S. Benzinger, Clifford R. Jack, Peter J. Snyder, Scott W. Andersen, J. Pariente, Andrew J. Aschenbrenner, Jason Hassenstab, Richard J. Perrin, Colin L. Masters, Chengjie Xiong, Jared R. Brosch, B. Joy Snider
Publikováno v:
Nat Med
Dominantly inherited Alzheimer's disease (DIAD) causes predictable biological changes decades before the onset of clinical symptoms, enabling testing of interventions in the asymptomatic and symptomatic stages to delay or slow disease progression. We
Autor:
Roy Yaari, Chung-Kai Sun, Kathryn V. Papp, Karen C. Holdridge, Reisa A. Sperling, Paul Maruff, Dorene M. Rentz, Michael A. Yassa, Adrian Schembri, Rema Raman, Michael C. Donohue, Paul S. Aisen, Alette M. Wessels, Craig E.L. Stark
Publikováno v:
The journal of prevention of Alzheimer's disease
Background: Computerized cognitive assessments may improve Alzheimer’s disease (AD) secondary prevention trial efficiency and accuracy. However, they require validation against standard outcomes and relevant biomarkers. Objective: To assess the fea
Autor:
Guoqiao, Wang, Yan, Li, Chengjie, Xiong, Eric, McDade, David B, Clifford, Susan L, Mills, Anna M, Santacruz, Andrew J, Aschenbrenner, Jason, Hassenstab, Tammie L S, Benzinger, Brian A, Gordon, Anne M, Fagan, Kelley A, Coalier, Jorge J, Libre-Guerra, Austin, McCullough, Nelly, Joseph-Mathurin, Charles D, Chen, Catherine, Mummery, Barbara A, Wendelberger, Serge, Gauthier, Mario, Masellis, Karen C, Holdridge, Roy, Yaari, Saptarshi, Chatterjee, John, Sims, Paul, Delmar, Geoffrey A, Kerchner, Tobias, Bittner, Carsten, Hofmann, Randall J, Bateman
Publikováno v:
Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 14
While the Dominantly Inherited Alzheimer Network Trials Unit (DIAN-TU) was ongoing, external data suggested higher doses were needed to achieve targeted effects; therefore, doses of gantenerumab were increased 5-fold, and solanezumab was increased 4-
Autor:
John R. Sims, Jennifer R. Gatchel, Gad A. Marshall, Rema Raman, Roy Yaari, Rebecca E. Amariglio, Paul S. Aisen, Karen C. Holdridge, Chung-Kai Sun, Dorene M. Rentz, Rachel F. Buckley, Sietske A.M. Sikkes, Joshua D. Grill, Keith A. Johnson, Michael C. Donohue, Reisa A. Sperling
Publikováno v:
Journal of Prevention of Alzheimer's Disease, 8(3), 257-262. Springer International Publishing AG
The journal of prevention of Alzheimer's disease
A4 Study Team 2021, ' Item-Level Investigation of Participant and Study Partner Report on the Cognitive Function Index from the A4 Study Screening Data ', Journal of Prevention of Alzheimer's Disease, vol. 8, no. 3, pp. 257-262 . https://doi.org/10.14283/jpad.2021.8
The journal of prevention of Alzheimer's disease
A4 Study Team 2021, ' Item-Level Investigation of Participant and Study Partner Report on the Cognitive Function Index from the A4 Study Screening Data ', Journal of Prevention of Alzheimer's Disease, vol. 8, no. 3, pp. 257-262 . https://doi.org/10.14283/jpad.2021.8
Background: Greater subjective cognitive changes on the Cognitive Function Index (CFI) was previously found to be associated with elevated amyloid (Aß) status in participants screening for the A4 Study, reported by study partners and the participant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ac90d6d301c4777a891d46a48d2b06
https://research.vumc.nl/en/publications/11eab1bd-57d2-4c47-9893-465aa12fa7e3
https://research.vumc.nl/en/publications/11eab1bd-57d2-4c47-9893-465aa12fa7e3
Autor:
Didier Hannequin, Jared R. Brosch, B. Joy Snider, Anna Santacruz, Anne M. Fagan, Suman Jayadev, William S. Brooks, Colin L. Masters, Erik D. Roberson, Mario Masellis, Susan Mills, Christopher H. Dyck, Florence Pasquier, Paulo Fontoura, Bruno Dubois, Monika Baudler, Lawrence S. Honig, Doug R. Galasko, James J. Lah, Peter J. Snyder, David Wallon, Geoffrey A. Kerchner, Eric McDade, Guoqiao Wang, Andrew J. Aschenbrenner, Jason Hassenstab, Roy Yaari, Ghulam M. Surti, Raquel Sánchez-Valle, Jérémie Pariente, Stephen Salloway, Carlos Cruchaga, Randall J. Bateman, Ivonne Z. Jimenez-Velazquez, Robert A. Koeppe, John C. Morris, Serge Gauthier, Clifford R. Jack, Sarah B. Berman, Alison Goate, Catherine J. Mummery, Martin R. Farlow, Karen C. Holdridge, Rachelle S. Doody, Tammie L.S. Benzinger, Scott W. Andersen, Chengjie Xiong, Ging-Yuek Robin Hsiung, Roger Clarnette, Paul Delmar, Maïté Formaglio, Mark A. Mintun, Kelley Coalier, John R. Sims, Brian A. Gordon, David B. Clifford
Publikováno v:
Alzheimer's & Dementia. 16
Autor:
Eric Siemers, Suzanne Hendrix, Alette M. Wessels, JonDavid Sparks, Michael Case, Paul S. Aisen, Scott W. Andersen, Hong Liu-Seifert, Karen C. Holdridge
Publikováno v:
Journal of Biopharmaceutical Statistics. 27:1104-1114
Little research has been conducted on the statistical properties of composite measures comprising linear combinations of continuous component scales. We assessed the quantitative relationship between the composites and their individual components reg
Publikováno v:
Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
Introduction Effectiveness of Alzheimer's disease (AD) treatments is commonly evaluated with coprimary outcomes; cognition with function to ensure clinical meaningfulness of a cognitive effect. Methods We reviewed the literature for functional outcom