Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Karen C. Angel"'
Publikováno v:
Chemical Research in Toxicology. 22:1086-1095
Oligonucleotides containing a site-specific N(6)-(2-deoxy-d-erythro-pentofuranosyl)-2,6-diamino-3,4-dihydro-4-oxo-5-N-methylformamidopyrimidine (MeFapy-dGuo) lesion were synthesized, and their in vitro replication by Escherichia coli DNA polymerase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525aac12f73e8061d29519e3d1373540
https://doi.org/10.1021/tx900047c
https://doi.org/10.1021/tx900047c
Publikováno v:
Journal of Biological Chemistry. 282:19831-19843
Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) has been shown to catalyze bypass of 7,8-dihydro-8-oxodeoxyguanosine (8-oxoG) in a highly efficient and relatively accurate manner. Crystal structures have revealed a potential role for Arg(332) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b22890f67b4311a7491eae42462f2708
https://doi.org/10.1074/jbc.m702290200
https://doi.org/10.1074/jbc.m702290200
Publikováno v:
Journal of Biological Chemistry. 282:13573-13584
Previous work has shown that Sulfolobus solfataricus DNA polymerase Dpo4-catalyzed bypass of O6-methylguanine (O6-MeG) proceeds largely in an accurate but inefficient manner with a “wobble” base pairing between C and O6-MeG (Eoff, R. L., Irimia,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f18dbb2e5cef5c1f7f0997be45979b9b
https://doi.org/10.1074/jbc.m700656200
https://doi.org/10.1074/jbc.m700656200
Autor:
Jeong-Yun Choi, Choua C. Vu, F. Peter Guengerich, Lisa A. Peterson, Goutam Chowdhury, Hong Zang, Karen C. Angel
Publikováno v:
Journal of Biological Chemistry. 281:38244-38256
Previous studies have shown that replicative bacterial and viral DNA polymerases are able to bypass the mutagenic lesions O(6)-methyl and -benzyl (Bz) G. Recombinant human polymerase (pol) delta also copied past these two lesions but was totally bloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85fe7aff1dc2d19a93185256e287e54c
https://doi.org/10.1074/jbc.m608369200
https://doi.org/10.1074/jbc.m608369200
Autor:
Carmelo J. Rizzo, Jeong-Yun Choi, Goutam Chowdhury, F. Peter Guengerich, Karen C. Angel, James S. Stover
Publikováno v:
Journal of Biological Chemistry. 281:25297-25306
Heterocyclic arylamines are highly mutagenic and cause tumors in animal models. The mutagenicity is attributed to the C8- and N2-G adducts, the latter of which accumulates due to slower repair. The C8- and N 2-G adducts derived from 2-amino-3-methyli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f88bb146f1814f2f6e582397beb82f9f
https://doi.org/10.1074/jbc.m605699200
https://doi.org/10.1074/jbc.m605699200
Publikováno v:
Chemical Research in Toxicology. 19:859-867
The mechanisms by which derivatives of polycyclic aromatic hydrocarbons (PAHs) cause mutations have been of considerable interest. Three different N(6)-adenyl PAH-diol epoxide oligonucleotide derivatives were studied with the archebacterial translesi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7201c71277534281ffa15bb7b6272dac
https://doi.org/10.1021/tx060056s
https://doi.org/10.1021/tx060056s
Autor:
Carmelo J. Rizzo, F. Peter Guengerich, Ivan D. Kozekov, Karen C. Angel, Hong Zang, Jeong-Yun Choi, Angela K. Goodenough
Publikováno v:
Chemical Research in Toxicology. 19:879-886
1,N(2)-Etheno(epsilon)guanine (epsilon) is formed in DNA as a result of exposure to certain vinyl monomers (e.g., vinyl chloride) or from lipid peroxidation. This lesion has been shown to be mutagenic in bacteria and mammalian cells. 1,N(2)-epsilon-G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18796e2a8aba163a93c046b627c8b5e6
https://doi.org/10.1021/tx060051v
https://doi.org/10.1021/tx060051v
Autor:
Angela K. Goodenough, Carmelo J. Rizzo, Martin Egli, Hong Zang, Jeong-Yun Choi, F. Peter Guengerich, Ivan D. Kozekov, Lioudmila V. Loukachevitch, Karen C. Angel, Adriana Irimia
Publikováno v:
Journal of Biological Chemistry. 280:29750-29764
1,N2-Etheno(ϵ)guanine is a mutagenic DNA lesion derived from lipid oxidation products and also from some chemical carcinogens. Gel electrophoretic analysis of the products of primer extension by Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4) in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b17cf05f212abb37e212a89b3617139
https://doi.org/10.1074/jbc.m504756200
https://doi.org/10.1074/jbc.m504756200
Autor:
Michael L. Cullivan, Larry A. Sonna, Craig M. Lilly, Karen C. Angel, Stephen L. Gaffin, Richard E. Pratt
Publikováno v:
Journal of Applied Physiology. 92:2208-2220
We studied the effect of heat shock on gene expression by normal human cells. Peripheral blood mononuclear cells (PBMCs) were obtained from healthy adults. Paired samples from each subject were subjected to either 20 min of heat shock (43°C) or cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fff45eb831dc3a7f9fb02415db6798c8
https://doi.org/10.1152/japplphysiol.01002.2001
https://doi.org/10.1152/japplphysiol.01002.2001
Autor:
Feng Wang, Carmelo J. Rizzo, Goutam Chowdhury, Karen C. Angel, Michael P. Stone, F. Peter Guengerich, Robert J. Turesky, C. Eric Elmquist, Albena Kozekova, Craig A. Garmendia, James S. Stover, Plamen P. Christov
Publikováno v:
Chemical research in toxicology. 23(6)
2-Amino-3-methylimidazo[4,5-f]naphthelene is a carbocyclic analogue of the dietary carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in which a naphthalene ring system replaces the quinoline unit of IQ. The activity of 2-amino-3-methylimidazo[4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374f478dd741515e55b05dcc385e8921
https://pubmed.ncbi.nlm.nih.gov/20377178
https://pubmed.ncbi.nlm.nih.gov/20377178