Zobrazeno 1 - 10
of 203
pro vyhledávání: '"Karen Bieback"'
Autor:
Merve Keles, Steve Grein, Natali Froese, Dagmar Wirth, Felix A. Trogisch, Rhys Wardman, Shruthi Hemanna, Nina Weinzierl, Philipp-Sebastian Koch, Stefanie Uhlig, Santosh Lomada, Gesine M. Dittrich, Malgorzata Szaroszyk, Ricarda Haustein, Jan Hegermann, Abel Martin-Garrido, Johann Bauersachs, Derk Frank, Norbert Frey, Karen Bieback, Julio Cordero, Gergana Dobreva, Thomas Wieland, Joerg Heineke
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 3, Pp 102306- (2024)
Pathological cardiac remodeling predisposes individuals to developing heart failure. Here, we investigated two co-regulated long non-coding RNAs (lncRNAs), termed Gadlor1 and Gadlor2, which are upregulated in failing hearts of patients and mice. Card
Externí odkaz:
https://doaj.org/article/35dc9f1f1a1a4ecda9219b0bc2786a74
Autor:
Xuehui Fan, Guoqiang Yang, Zhen Yang, Stefanie Uhlig, Katherine Sattler, Karen Bieback, Nazha Hamdani, Ibrahim El-Battrawy, Daniel Duerschmied, Xiaobo Zhou, Ibrahim Akin
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 116928- (2024)
Endothelial dysfunction contributes to the pathogenesis of Takotsubo syndrome (TTS). However, the exact mechanism underlying endothelial dysfunction in the setting of TTS has not been completely clarified. This study aims to investigate the roles of
Externí odkaz:
https://doaj.org/article/b0542bc8ca4d40fe9d591a793e101d7d
Autor:
Luisa Tengler, Moritz Tiedtke, Julia Schütz, Karen Bieback, Stefanie Uhlig, Marie-Nicole Theodoraki, Katja Nitschke, Thomas Stefan Worst, Elena Seiz, Claudia Scherl, Nicole Rotter, Sonja Ludwig
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract Small extracellular vesicles from saliva (SEVs) have high potential as biomarkers in Head and Neck cancer (HNC). However, there is no common consensus on the ideal method for their isolation. This study compared different ultracentrifugation
Externí odkaz:
https://doaj.org/article/85dae743409c4b7ab7ae3db9fd7f4118
Autor:
Renata Skovronova, Eleonora Scaccia, Sandra Calcat-i-Cervera, Benedetta Bussolati, Timothy O’Brien, Karen Bieback
Publikováno v:
Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-16 (2023)
Abstract Background Extracellular vesicles (EV) are considered a cell-free alternative to mesenchymal stromal cell (MSC) therapy. Numerous reports describe the efficacy of EV in conferring immunomodulation and promoting angiogenesis, yet others repor
Externí odkaz:
https://doaj.org/article/e00065f93b3f4c43885f9053132042a9
Autor:
Sandra Calcat-i-Cervera, Erika Rendra, Eleonora Scaccia, Francesco Amadeo, Vivien Hanson, Bettina Wilm, Patricia Murray, Timothy O’Brien, Arthur Taylor, Karen Bieback
Publikováno v:
Stem Cell Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Background Mesenchymal stromal cells (MSCs), commonly sourced from adipose tissue, bone marrow and umbilical cord, have been widely used in many medical conditions due to their therapeutic potential. Yet, the still limited understanding of t
Externí odkaz:
https://doaj.org/article/6e677206ca534025a0e639dd69a926f4
Autor:
Erika Rendra, Adriana Torres Crigna, Cristina Daniele, Carsten Sticht, Maike Cueppers, Mark Andreas Kluth, Christoph Ganss, Markus H. Frank, Norbert Gretz, Karen Bieback
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Acute kidney injury (AKI) is characterized by a rapid reduction in renal function and glomerular filtration rate (GFR). The broadly used anti-cancer chemotherapeutic agent cisplatin often induces AKI as an adverse drug side effect. Therapies targeted
Externí odkaz:
https://doaj.org/article/eda2ae136f194118a0671792b264cd29
Autor:
Tamiris Borges da Silva, Erika Rendra, Christopher A.W. David, Karen Bieback, Michael J. Cross, Bettina Wilm, Neill J. Liptrott, Patricia Murray
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 167, Iss , Pp 115624- (2023)
Mesenchymal stromal cells (MSCs) have been reported to display efficacy in a variety of preclinical models, but without long-term engraftment, suggesting a role for secreted factors, such as MSC-derived extracellular vesicles (EVs). MSCs are known to
Externí odkaz:
https://doaj.org/article/00ddb04672a54d6299c910861d8fcd0f
Autor:
Erika Rendra, Stefanie Uhlig, Isabell Moskal, Corinna Thielemann, Harald Klüter, Karen Bieback
Publikováno v:
Cells, Vol 13, Iss 2, p 121 (2024)
(1) Background: The chemotherapeutic drug cisplatin exerts toxic side effects causing acute kidney injury. Mesenchymal stromal cells can ameliorate cisplatin-induced kidney injury. We hypothesize that the MSC secretome orchestrates the vicious cycle
Externí odkaz:
https://doaj.org/article/e9143bf765834f4cbae752f9fd2f22f1
Autor:
Michael Keese, Jiaxing Zheng, Kaixuan Yan, Karen Bieback, Benito A. Yard, Prama Pallavi, Christoph Reissfelder, Mark Andreas Kluth, Martin Sigl, Vugar Yugublu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 24, p 17197 (2023)
Adipose-derived stem cells (ASCs) have been used as a therapeutic intervention for peripheral artery disease (PAD) in clinical trials. To further explore the therapeutic mechanism of these mesenchymal multipotent stromal/stem cells in PAD, this study
Externí odkaz:
https://doaj.org/article/22de4abea02e49b9959c46e9711a9034
Autor:
Hélène Willer, Gabriele Spohn, Kimberly Morgenroth, Corinna Thielemann, Susanne Elvers-Hornung, Peter Bugert, Bruno Delorme, Melanie Giesen, Thomas Schmitz-Rixen, Erhard Seifried, Christiane Pfarrer, Richard Schäfer, Karen Bieback
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Human Mesenchymal Stromal Cells (hMSCs) are a promising source for cell-based therapies. Yet, transition to phase III and IV clinical trials is remarkably slow. To mitigate donor variabilities and to obtain robust and valid clinical data, we aimed fi
Externí odkaz:
https://doaj.org/article/5373656f19b54ecbaf9a6cac11c3bbdb