Výsledky vyhledávání - "Karen B. Young"

Structure and expression of the mouse cardiac calsequestrin gene

Autor: Guoxiang Chu, Evangelia G. Kranias, Wen Zhao, Karen B. Young, Konrad Frank, Yoji Sato, Laurence Mesnard-Rouiller, Kobra Haghighi

Publikováno v: Basic Research in Cardiology. 96:636-644

Calsequestrin is a sarcoplasmic reticulum protein, which plays a predominant role in diastolic Ca2+-storage in the mammalian heart. The present study was designed to define the gene structure, developmental and tissue specific expression of the murin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39138107b0093d29ad2b2ab506692325
https://doi.org/10.1007/s003950170016

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Overexpression of phospholamban in slow‐twitch skeletal muscle is associated with depressed contractile function and muscle remodeling

Autor: Karen B. Young, Evangelia G. Kranias, Michael J Gerst, James Gulick, Jeffrey Robbins, Qiujing Song, Guoxiang Chu, Ingrid L. Grupp

Publikováno v: The FASEB Journal. 18:974-976

The relative amount of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) and its crucial inhibitor phospholamban (PLN) are closely regulated and play a pivotal role in maintaining muscle function. The functional importance of PLN has been intensively inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c7371dde9960fa1cba900e5ae6d4576
https://doi.org/10.1096/fj.03-1058fje

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EXPLORING SPIRITUAL WELL-BEING AMONG SURVIVORS OF COLORECTAL AND LUNG CANCER

Autor: Karen B. Young, Costellia H. Talley, Kimberly S. Clay

Publikováno v: Journal of religionspirituality in social work. 29(1)

This descriptive, exploratory study is part of a larger observational study of the quality of cancer care delivered to population-based cohorts of newly-diagnosed patients with lung and colorectal cancer. The current study explores the role of spirit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4108fd8539d30f513ea30e7eca95c084
https://pubmed.ncbi.nlm.nih.gov/20625520

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Enhanced myocyte contractility and Ca2+ handling in a calcineurin transgenic model of heart failure

Autor: Karen B. Young, Jeffrey Robbins, Melissa C. Colbert, Guoxiang Chu, Paul D. Lampe, Konrad Frank, Evangelia G. Kranias, Atsushi Sanbe, Steven M. Schwartz, Andrew N. Carr, Atsuko Yatani, Jeffery D. Molkentin, J.William Lester

Publikováno v: Cardiovascular research. 54(1)

Objective: Impaired myocyte Ca2+ handling is a common characteristic of failing hearts and increases in calcineurin activity, a Ca2+-sensitive phosphatase, have been implicated in heart failure phenotype. Transgenic mice with cardiac-specific express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a70a8f6bc6d14ec096da32c3fcdce1
https://pubmed.ncbi.nlm.nih.gov/12062367

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Genetic Alterations and Modeling of Cardiovascular Physiology

Autor: Albrecht Schmidt, Evangelia G. Kranias, Vivek J. Kadambi, Karen B. Young

Publikováno v: Developments in Cardiovascular Medicine ISBN: 9781461356615

Animal models have provided invaluable tools in improving our understanding of cardiac physiology and the mechanisms underlying heart disease. Until recently, available models were generated by surgical or pharmacological interventions or were the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5388d447e2cb6795431cd8867a04c5be
https://doi.org/10.1007/978-1-4615-1653-8_2

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A single site (Ser16) phosphorylation in phospholamban is sufficient in mediating its maximal cardiac responses to beta -agonists

Autor: Guoxiang Chu, James W. Lester, Wusheng Luo, Evangelia G. Kranias, Jing Zhai, Karen B. Young

Publikováno v: The Journal of biological chemistry. 275(49)

Phospholamban (PLB) can be phosphorylated at Ser(16) by cyclic AMP-dependent protein kinase and at Thr(17) by Ca(2+)-calmodulin-dependent protein kinase during beta-agonist stimulation. A previous study indicated that mutation of S16A in PLB resulted

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3573256e270c2f46c0136e0435424f3a
https://pubmed.ncbi.nlm.nih.gov/10988285

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