Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Karen B. Whittington"'
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245541 (2021)
While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated proteins. To investigate the role of citrull
Externí odkaz:
https://doaj.org/article/329c055308a6492b9e793275457ab734
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245541 (2021)
PLoS ONE
PLoS ONE
While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated proteins. To investigate the role of citrull
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98d218ffbeb2c054d7b394cd3e8ed50d
https://doaj.org/article/329c055308a6492b9e793275457ab734
https://doaj.org/article/329c055308a6492b9e793275457ab734
Publikováno v:
Arthritis Research & Therapy
Background Fingolimod (FTY720) is an immunomodulating drug that inhibits sphingosine-1-phosphate binding and blocks T-cell egress from lymph nodes. We analyzed the effect of FTY720 on the autoimmune T- and B-cell response in autoimmune arthritis and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110e29591163b20a59ed4c9b029b8667
https://doi.org/10.1186/s13075-015-0909-6
https://doi.org/10.1186/s13075-015-0909-6
Autor:
Kary A. Latham, Edward F. Rosloniec, Zhaohui Qian, Karen B. Whittington, David D. Brand, David C. Miller
Publikováno v:
The Journal of Immunology. 185:110-118
Although it is clear that CD4+ T cells play a major role in mediating the pathogenesis of autoimmunity, they often represent only a minor population at the site of inflammation in autoimmune diseases. To investigate the migration and specificity of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1232ec0c670841eb22d4c06dd90a53e2
https://doi.org/10.4049/jimmunol.1000416
https://doi.org/10.4049/jimmunol.1000416
Publikováno v:
The Journal of Immunology. 177:3884-3892
The expression of HLA-DR1 (DRB1*0101) is associated with an enhanced risk for developing rheumatoid arthritis (RA). To study its function, we have solved the three-dimensional structure of HLA-DR1 complexed with a candidate RA autoantigen, the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc08affcd40b0cea5d13420291f4c1d0
https://doi.org/10.4049/jimmunol.177.6.3884
https://doi.org/10.4049/jimmunol.177.6.3884
Publikováno v:
The Journal of Immunology. 168:253-259
Rheumatoid arthritis is an autoimmune disease in which susceptibility is strongly associated with the expression of specific HLA-DR haplotypes, including DR1 (DRB1*0101) and DR4 (DRB1*0401). As transgenes, both of these class II molecules mediate sus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41eebf4972faec442f5b2dc6bd5ef9b
https://doi.org/10.4049/jimmunol.168.1.253
https://doi.org/10.4049/jimmunol.168.1.253
Publikováno v:
Autoimmunity. 34:133-145
Susceptibility to collagen induced arthritis (CIA) in the murine model is linked to expression of the MHC class II alleles, I-Aq and I-Ar. We have examined the molecular basis for this MHC-linked susceptibility by studying the antigen presentation fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39edc822fead42207ea444850f9bdb12
https://doi.org/10.3109/08916930109001961
https://doi.org/10.3109/08916930109001961
Autor:
Bo Tang, Linda K. Myers, Edward F. Rosloniec, Karen B. Whittington, John M. Stuart, Andrew H. Kang
Publikováno v:
The Journal of Immunology. 160:3135-3142
The immunodominant T cell determinant of type II collagen (CII) recognized by DBA/1 mice (I-Aq) is CII 260–267. The aims of this study were to determine the role of the amino acid residues within CII 245–270 in T cell signal transduction. To that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc2120fd100e7b0f7d1fd6368a6191a3
https://doi.org/10.4049/jimmunol.160.7.3135
https://doi.org/10.4049/jimmunol.160.7.3135
Autor:
Edward F. Rosloniec1, David D. Brand, Linda K. Myers, Yukio Esaki, Karen B. Whittington, Dennis M. Zaller, Andrea Woods, John M. Stuart, Andrew H. Kang
Publikováno v:
The Journal of Immunology. 160:2573-2578
Although associations between the expression of particular HLA genes and the susceptibility to specific autoimmune diseases has been known for some time, the role that these HLA molecules play in the autoimmune response is unclear. Through the establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2312a0d0aa0264ba06ff4a72cb2159fb
https://doi.org/10.4049/jimmunol.160.6.2573
https://doi.org/10.4049/jimmunol.160.6.2573
Autor:
Kary A. Latham, Karen B. Whittington, Zhaohui Qian, David D. Brand, David C. Miller, Edward F. Rosloniec
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 190(11)
Regulatory T cells (Tregs) are critical homeostatic components in preventing the development of autoimmunity, and are a major focus for their therapeutic potential for autoimmune diseases. To enhance the efficacy of Tregs in adoptive therapy, we deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ed2abe078737cf137684034430b8b39
https://pubmed.ncbi.nlm.nih.gov/23630354
https://pubmed.ncbi.nlm.nih.gov/23630354