Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Karen B. Jourdan"'
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 287:L352-L359
Long-term infusion of prostacyclin, or its analogs, is an effective treatment for severe pulmonary arterial hypertension. However, dose escalation is often required to maintain efficacy. The aim of this study was to investigate the mechanisms of pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ece174ef4ec6640997b74df9c250b4ef
https://doi.org/10.1152/ajplung.00270.2003
https://doi.org/10.1152/ajplung.00270.2003
Autor:
Karen Sheares, Nicholas W. Morrell, Paul D. Upton, Xudong Yang, Karen B. Jourdan, Richard C. Trembath, Neal Morgan
Publikováno v:
Circulation. 104:790-795
Background Mutations in the type II receptor for bone morphogenetic protein (BMPR-II), a receptor member of the transforming growth factor-β (TGF-β) superfamily, underlie many cases of familial and sporadic primary pulmonary hypertension (PPH). We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5d475a21d5c54e76f4f8e5dc1e9338
https://doi.org/10.1161/hc3201.094152
https://doi.org/10.1161/hc3201.094152
Autor:
Karen B. Jourdan, Nicholas W. Morrell, N. A. Mason, Lu Long, Martin R. Wilkins, Peter G. Philips
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 280:L1359-L1369
Activation of adenylyl cyclase (AC), of which there are 10 diversely regulated isoforms, is important in regulating pulmonary vascular tone and remodeling. Immunohistochemistry in rat lungs demonstrated that AC2, AC3, and AC5/6 predominated in vascul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c2c18784cd052b2cc1cd6c8a448a3d7
https://doi.org/10.1152/ajplung.2001.280.6.l1359
https://doi.org/10.1152/ajplung.2001.280.6.l1359
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 21:105-110
Pulmonary hypertension is characterized by hypertrophy and hyperplasia of vascular smooth muscle occurring via an unknown mechanism. Cyclooxygenase (COX)-2 and inducible nitric oxide synthase (iNOS) are expressed under inflammatory conditions and pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::827d4cb4ea1e7b2101dba1c4f7b98548
https://doi.org/10.1165/ajrcmb.21.1.3502
https://doi.org/10.1165/ajrcmb.21.1.3502
Publikováno v:
British Journal of Pharmacology. 120:1280-1285
1. 8-Iso prostaglandin F2 alpha (8-iso PGF2 alpha) is one of a series of prostanoids formed independently of the cyclo-oxygenase pathway. It has been shown to be upregulated in many conditions of oxidant stress where its formation is induced by free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3006478169d0b7ce07e608e9fbce7881
https://doi.org/10.1038/sj.bjp.0701052
https://doi.org/10.1038/sj.bjp.0701052
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 13(9)
The isoprostanes are a group of biologically active arachidonic acid metabolites initially thought to be formed under conditions of oxidative stress and independently of cyclooxygenase. However, recent studies have demonstrated isoprostane production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82697741f0c502ebef9224ea5e4de2d8
https://pubmed.ncbi.nlm.nih.gov/10336884
https://pubmed.ncbi.nlm.nih.gov/10336884
Publikováno v:
Biochemical and biophysical research communications. 233(3)
Isoprostanes are prostaglandin (PG)-like compounds initially described as formed by a direct action of radicals on arachidonic acid. However, the isoprostane 8-iso PGF2 alpha, is released by platelets and monocytes by cyclo-oxygenase dependent pathwa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52fdaf9b7c6d5348526a16f8141cad3
https://pubmed.ncbi.nlm.nih.gov/9168911
https://pubmed.ncbi.nlm.nih.gov/9168911
Publikováno v:
Critical care medicine. 24(12)
Objective : Sepsis is characterized by systemic vasodilation and hyporesponsiveness to constrictor agents, at a time when the pulmonary circulation exhibits varying degrees of vasoconstriction. Plasma endothelin-1 concentrations are increased, but th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46213c4b00f09516ab2f29b7e6e92f44
https://pubmed.ncbi.nlm.nih.gov/8968269
https://pubmed.ncbi.nlm.nih.gov/8968269