Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Karen Akinsanya"'
Autor:
Alan S. Futran, Tao Lu, Katherine Amberg-Johnson, Jiayi Xu, Xiaoxiao Yang, Saidi He, Sarah Boyce, Jeffrey A. Bell, Robert Pelletier, Takao Suzuki, Xianhai Huang, Heng Qian, Liping Fang, Li Xing, Zhaowu Xu, Stephen E. Kurtz, Jeffrey W. Tyner, Wayne Tang, Tao Guo, Karen Akinsanya, David Madge, Kristian K. Jensen
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109693- (2024)
Summary: The USP7 deubiquitinase regulates proteins involved in the cell cycle, DNA repair, and epigenetics and has been implicated in cancer progression. USP7 inhibition has been pursued for the development of anti-cancer therapies. Here, we describ
Externí odkaz:
https://doaj.org/article/ad0bc59a163a477bae0474b6a3ff6a2d
Autor:
Adam Olszewski, David Kahn, Brian Yoo, Zhe Nie, Goran Krilov, Joanne Tan, Hamish Wright, Daniel Weiss, Wu Yin, Karen Akinsanya
Publikováno v:
HemaSphere, Vol 7, p e40906a2 (2023)
Externí odkaz:
https://doaj.org/article/c2d45a9f909a49f5a88cdda9039a17d1
Autor:
Roshni R. Singaraja, Ian Tietjen, G. Kees Hovingh, Patrick L. Franchini, Chris Radomski, Kenny Wong, Margaret vanHeek, Ioannis M. Stylianou, Linus Lin, Liangsu Wang, Lyndon Mitnaul, Brian Hubbard, Michael Winther, Maryanne Mattice, Annick Legendre, Robin Sherrington, John J. Kastelein, Karen Akinsanya, Andrew Plump, Michael R. Hayden
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 8, Pp 1693-1701 (2014)
While genetic determinants strongly influence HDL cholesterol (HDLc) levels, most genetic causes underlying variation in HDLc remain unknown. We aimed to identify novel rare mutations with large effects in candidate genes contributing to extreme HDLc
Externí odkaz:
https://doaj.org/article/3119e73763574be8bb7cf6c60fea70f6
Autor:
Richard Hargreaves, Karen Akinsanya, Seena K. Ajit, Neel T. Dhruv, Jamie Driscoll, Peter Farina, Narender Gavva, Marie Gill, Andrea Houghton, Smriti Iyengar, Carrie Jones, Annemieke Kavelaars, Ajamete Kaykas, Walter J. Koroshetz, Pascal Laeng, Jennifer M. Laird, Donald C. Lo, Johan Luthman, Gordon Munro, Michael L. Oshinsky, G. Sitta Sittampalam, Sarah A. Woller, Amir P. Tamiz
Publikováno v:
Expert Opinion on Therapeutic Targets. 26:811-822
The Helping to End Addiction Long-termIn 2020, the National Institutes of Health (NIH) held the Target Validation for Non-Addictive Therapeutics Development for Pain workshop to gather insights from key opinion leaders in academia, industry, and vent
Publikováno v:
Drug Discovery Today: Technologies. 39:111-117
Computational chemistry and structure-based design have traditionally been viewed as a subset of tools that could aid acceleration of the drug discovery process, but were not commonly regarded as a driving force in small molecule drug discovery. In t
Autor:
Lyuben Tsvetkov, Janét Pittsenbarger, Christian Atsriku, Paul Devine, Karen Dingley, Adam Levinson, Sayan Mondal, Joseph Piccotti, Roman Shimanovich, Lin Tang, Daniel Weiss, Jacky Woo, Min Ye, Wu Yin, Karen Akinsanya, Wayne Tang, Hamish Wright, Elie Traer, Kristian Jensen
Publikováno v:
Blood. 140:5961-5962
Autor:
Wu Yin, Zhe Nie, Karen Dingley, Michael Trzoss, Goran Krilov, Netonia Marshall, Shulu Feng, Robert Pelletier, Jeff Bell, Paul Devine, Peter Skrdla, Roman Shimanovich, Min Ye, David Calkins, Mary Grimes, Wayne Tang, Andrew Placzek, Morgan Lawrenz, Fiona McRobb, Aleksey Gerasyuto, Victoria Feher, Sayan Mondal, Kristian Jensen, Hamish Wright, Daniel Weiss, Karen Akinsanya
Publikováno v:
Blood. 138:1187-1187
Introduction: MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1) is a key mediator of the NF-κB signaling pathway, the main driver of a subset of B-cell lymphomas and functions by forming a complex with CARMA1 and BCL10 to me
Autor:
Liping Fang, Takao Suzuki, Kristian Jensen, Mats A. Svensson, Robert Pelleltier, Jeffrey A. Bell, Zef Konst, Hamish Wright, Wayne Tang, Katherine Amberg-Johnson, Shuping Xu, Xianhai Huang, Karen Dingley, Yan Zhang, Heng Qian, Markus K. Dahlgren, Michael Trzoss, Alan Futran, Karen Akinsanya, Xiaoxiao Yang, Sarah Boyce, Saidi He, Li Xing, Jiayi Xu, Tao Guo, David Madge, Tao Lu, Heidi Koldsoe, Fang-Yu Lin, Zhaowu Xu, Jie Xu, Engin Yapici
Publikováno v:
Cancer Research. 81:1338-1338
Introduction: Ubiquitin-specific protease 7 (USP7) is a deubiquitinase that regulates several proteins involved in cell cycle, DNA repair, genomic stability, and epigenetics and has been implicated in cancer progression. A key substrate of USP7 is MD
Autor:
Kristian Jensen, Wayne Tang, Mary Grimes, David Calkins, W. George Lai, Sayan Mondal, Victoria A. Feher, Jeff Bell, Wu Yin, Fiona M. McRobb, Shulu Feng, Michael Trzoss, Goran Krilov, Hamish Wright, Andrew Placzek, Robert Pelletier, Morgan Lawrenz, Nie Zhe, Aleksey Gerasyuto, Karen Akinsanya
Publikováno v:
Blood. 136:30-30
Introduction: MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1), was identified as a translocation protein fused with cIAP2 in mucosa-associated lymphoid tissue (MALT) B cell lymphomas. MALT1, a key mediator of NF-κB signali
Autor:
Jose, Castro-Perez, Nathan, Hatcher, Nana, Kofi Karikari, Sheng-Ping, Wang, Vivienne, Mendoza, Henry, Shion, Alan, Millar, John, Shockcor, Mark, Towers, David, McLaren, Vinit, Shah, Stephen, Previs, Karen, Akinsanya, Michele, Cleary, Thomas P, Roddy, Douglas G, Johns
Publikováno v:
Rapid communications in mass spectrometry : RCM. 28(22)
The ability to quantify rates of formation, regression and/or remodeling of atherosclerotic plaque should facilitate a better understanding of the pathogenesis and management of cardiovascular disease. In the current study, we coupled a stable isotop