Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Karen Agaronyan"'
Publikováno v:
Immunity. 56:687-694
Autor:
Xiaohua Peng, Jooyoung Kim, Gayatri Gupta, Karen Agaronyan, Madeleine C. Mankowski, Asawari Korde, Shervin S. Takyar, Hyeon Jun Shin, Victoria Habet, Sarah Voth, Jonathon P. Audia, De Chang, Xinran Liu, Lin Wang, Ying Cai, Xuefei Tian, Shuta Ishibe, Min-Jong Kang, Susan Compton, Craig B. Wilen, Charles S. Dela Cruz, Lokesh Sharma
Publikováno v:
J Immunol
Postviral bacterial infections are a major health care challenge in coronavirus infections, including COVID-19; however, the coronavirus-specific mechanisms of increased host susceptibility to secondary infections remain unknown. In humans, coronavir
Autor:
Paloma Martinez-Redondo, Dongmei Ji, Taosheng Huang, Refik Kayali, David M. Lee, Karen Agaronyan, Shiyu Luo, Shoukhrat Mitalipov, Nuria Marti Gutierrez, Ying Li, Crystal Van Dyken, Diana Wu, Jeffrey T. Jensen, Hong Ma, Riffat Ahmed, Aida Platero-Luengo, Xinjian Wang, Rebecca Tippner-Hedges, David Battaglia, Dmitry Temiakov, Juan Carlos Izpisua Belmonte, Amy Koski, Jun Wu, Paula Amato, Eunju Kang, Susan B. Olson, Don P. Wolf, Cengiz Cinnioglu, Tomonari Hayama, Yeon-Mi Lee
Publikováno v:
Nature. 567:E5-E9
Change history In this Letter, there are several errors regarding the assignments of mtDNA haplotypes for a subset of egg donors from our study. These errors have not been corrected online.
Autor:
Karen, Agaronyan, Lokesh, Sharma, Bharat, Vaidyanathan, Keith, Glenn, Shuang, Yu, Charles, Annicelli, Talia D, Wiggen, Mitchell R, Penningroth, Ryan C, Hunter, Charles S, Dela Cruz, Ruslan, Medzhitov
Publikováno v:
Immunity. 55:895-911.e10
Different effector arms of the immune system are optimized to protect from different classes of pathogens. In some cases, pathogens manipulate the host immune system to promote the wrong type of effector response-a phenomenon known as immune deviatio
Autor:
Rebecca Tippner-Hedges, Crystal Van Dyken, David Battaglia, David M. Lee, Eunju Kang, Paloma Martinez-Redondo, Karen Agaronyan, Shiyu Luo, Refik Kayali, Jun Wu, Paula Amato, Don P. Wolf, Cengiz Cinnioglu, Tomonari Hayama, Yeon-Mi Lee, Shoukhrat Mitalipov, Nuria Marti Gutierrez, Jeffrey T. Jensen, Diana Wu, Aida Platero-Luengo, Taosheng Huang, Xinjian Wang, Dmitry Temiakov, Dongmei Ji, Juan Carlos Izpisua Belmonte, Amy Koski, Susan B. Olson, Ying Li, Hong Ma, Riffat Ahmed
Publikováno v:
Nature. 540:270-275
Maternally inherited mitochondrial (mt)DNA mutations can cause fatal or severely debilitating syndromes in children, with disease severity dependent on the specific gene mutation and the ratio of mutant to wild-type mtDNA (heteroplasmy) in each cell
Autor:
Michael Anikin, James J. Graber, Kathrin Schwinghammer, Hauke S. Hillen, Karen Agaronyan, Andrey V. Parshin, Patrick Cramer, Aleksandar Chernev, Dmitry Temiakov, Yaroslav I. Morozov, Henning Urlaub
Publikováno v:
Cell
Cell 171(5), 1082-1093.e13 (2017). doi:10.1016/j.cell.2017.09.035
Cell 171(5), 1082-1093.e13 (2017). doi:10.1016/j.cell.2017.09.035
Summary In human mitochondria, transcription termination events at a G-quadruplex region near the replication origin are thought to drive replication of mtDNA by generation of an RNA primer. This process is suppressed by a key regulator of mtDNA—th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::459e21540c4a9e254fa77605e2716941
https://hdl.handle.net/11858/00-001M-0000-002E-8714-911858/00-001M-0000-002E-8715-711858/00-001M-0000-002E-0F77-0
https://hdl.handle.net/11858/00-001M-0000-002E-8714-911858/00-001M-0000-002E-8715-711858/00-001M-0000-002E-0F77-0
Publikováno v:
Science. 347:548-551
Switching transcription and replication Because mitochondrial DNA is circular, the transcription and replication machinery might be expected to collide. A single mitochondrial RNA polymerase (mtRNAP) transcribes the mitochondrial DNA and also generat
Autor:
Patrick Cramer, Alan C. M. Cheung, Karen Agaronyan, Dmitry Temiakov, Yaroslav I. Morozov, Michael Anikin
Publikováno v:
Nucleic Acids Research
The mitochondrial genome is transcribed by a single-subunit T7 phage-like RNA polymerase (mtRNAP), structurally unrelated to cellular RNAPs. In higher eukaryotes, mtRNAP requires two transcription factors for efficient initiation—TFAM, a major nucl
Autor:
Alan C. M. Cheung, Yaroslav I. Morozov, Karen Agaronyan, Patrick Cramer, Dmitry Temiakov, Kathrin Schwinghammer
Publikováno v:
Nature Structural & Molecular Biology
Nature Structural and Molecular Biology
Nature structural & molecular biology
Nature Structural and Molecular Biology
Nature structural & molecular biology
Here we report the crystal structure of the human mitochondrial RNA polymerase (mtRNAP) transcription elongation complex, determined at 2.65-A resolution. The structure reveals a 9-bp hybrid formed between the DNA template and the RNA transcript and