Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Karen A. Yates"'
Autor:
Daniel L. Flynn, Michael Clare, Lance J. Stewart, Lawrence Chun, Karen M. Yates, Subha Vogeti, Lakshminarayana Vogeti, Hanumaiah Telikepalli, Thiwanka Samarakoon, Thomas J. Rutkoski, William C. Patt, Tristan W. Patt, Wei-Ping Lu, Molly M. Hood, Carol L. Ensinger, Timothy M. Caldwell, R. John Booth, Yu Mi Ahn, Scott C. Wise, Benjamin A. Turner, Cynthia B. Leary, Michael D. Kaufman, Bryan D. Smith
Altiratinib (DCC-2701) was designed based on the rationale of engineering a single therapeutic agent able to address multiple hallmarks of cancer (1). Specifically, altiratinib inhibits not only mechanisms of tumor initiation and progression, but als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4a49f1af80ca00d7cc02eb5848964921
https://doi.org/10.1158/1535-7163.c.6536815.v1
https://doi.org/10.1158/1535-7163.c.6536815.v1
Autor:
Daniel L. Flynn, Michael Clare, Lance J. Stewart, Lawrence Chun, Karen M. Yates, Subha Vogeti, Lakshminarayana Vogeti, Hanumaiah Telikepalli, Thiwanka Samarakoon, Thomas J. Rutkoski, William C. Patt, Tristan W. Patt, Wei-Ping Lu, Molly M. Hood, Carol L. Ensinger, Timothy M. Caldwell, R. John Booth, Yu Mi Ahn, Scott C. Wise, Benjamin A. Turner, Cynthia B. Leary, Michael D. Kaufman, Bryan D. Smith
Supplementary Materials and Methods. Supplementary table 1: XRay crystallography parameters for DP-4157/MET complex. Supplementary table 2: Source and description of kinases. Supplementary table 3: Selectivity of profile of altiratinib inhibition fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b914b7bf5b2f07136ac99e3d894850d
https://doi.org/10.1158/1535-7163.22501534
https://doi.org/10.1158/1535-7163.22501534
Autor:
Timothy M. Caldwell, Michael D. Kaufman, Scott C. Wise, Yu Mi Ahn, Molly M. Hood, Wei-Ping Lu, William C. Patt, Thiwanka Samarakoon, Lakshminarayana Vogeti, Subha Vogeti, Karen M. Yates, Stacie L. Bulfer, Bertrand Le Bourdonnec, Bryan Smith, Daniel Flynn
Publikováno v:
Bioorganicmedicinal chemistry letters. 74
Based on the structure of an early lead identified in Deciphera's proprietary compound collection of switch control kinase inhibitors and using a combination of medicinal chemistry guided structure activity relationships and structure-based drug desi
Autor:
Sophia R. McGuirk, Holly R. Hughes, J. Erin Staples, Amy J. Lambert, Barb Schroder, Jason O. Velez, Molly Baker, S. Hasan Naqvi, Olga I. Kosoy, Karen F Yates, George Turabelidze, Howard Pue
Publikováno v:
Clinical Infectious Diseases. 73:1700-1702
An adult male from Missouri sought care for fever, fatigue, and gastrointestinal symptoms. He had leukopenia and thrombocytopenia and was treated for a presumed tickborne illness. His condition deteriorated with respiratory and renal failure, lactic
Autor:
Molly M. Hood, Arin McKinley, Bryan D. Smith, Subha Vogeti, Gada Al-Ani, Wei Ping Lu, Ying Su, Ajia Town, Timothy M. Caldwell, Daniel L. Flynn, Lakshminarayana Vogeti, Michael Heinrich, Cynthia B. Leary, Patt William Chester, Lawrence Chun, Benjamin A. Turner, Oliver Rosen, Albiruni Ryan Abdul Razak, Karen M. Yates, Michael Kaufman, Carol L. Ensinger, Filip Janku, Rodrigo Ruiz-Soto, Hanumaiah Telikepalli, Yu Mi Ahn, Anu Gupta, Thomas J. Rutkoski, Stacie L. Bulfer, Scott C. Wise
Publikováno v:
Cancer cell. 35(5)
Ripretinib (DCC-2618) was designed to inhibit the full spectrum of mutant KIT and PDGFRA kinases found in cancers and myeloproliferative neoplasms, particularly in gastrointestinal stromal tumors (GISTs), in which the heterogeneity of drug-resistant
Autor:
Bryan D. Smith, Lakshminarayana Vogeti, Quanrong Shen, Cynthia B. Leary, Chase K Crawley, Karen M. Yates, Cale L Heiniger, Hikmat Al-Hashimi, Timothy M. Caldwell, Anu Gupta, Mary J Timson, Hanumaiah Telikepalli, Justin T Proto, Daniel L. Flynn, Gada Al-Ani, Subha Vogeti, Wei-Ping Lu, Jarnail Singh, Yu Mi Ahn, Stacie L. Bulfer
Publikováno v:
Molecular Cancer Therapeutics. 18:B129-B129
Background: Cancer cells activate autophagy, a catabolic process to resupply nutrients and recycle damaged organelles, in order to survive stresses such as limited nutrients and hypoxia, or chemotherapy treatments. RAS mutant cancers, in particular,
Autor:
Jason W. A. Robinson, Karen A. Yates, L. A. B. Olde Olthof, Mehmet Egilmez, Lesley F. Cohen, Dharmalingam Prabhakaran, Mary E. Vickers
As charge carriers traverse a single superconductor ferromagnet interface they experience an additional spin-dependent phase angle which results in spin mixing and the formation of a bound state called the Andreev Bound State. This state is an essent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::300424ca76e40d8d50b81f0e44d9ea07
https://ora.ox.ac.uk/objects/uuid:22256aca-2bf6-44db-a28c-e5c97f997ddd
https://ora.ox.ac.uk/objects/uuid:22256aca-2bf6-44db-a28c-e5c97f997ddd
Autor:
R. John Booth, Bryan D. Smith, Daniel L. Flynn, Lance Stewart, Tristan W. Patt, Scott C. Wise, Timothy M. Caldwell, Benjamin A. Turner, Molly M. Hood, Thomas J. Rutkoski, Wei-Ping Lu, Yu Mi Ahn, Michael Kaufman, Hanumaiah Telikepalli, Michael Clare, Subha Vogeti, Patt William Chester, Thiwanka Bandara Samarakoon, Karen M. Yates, Lakshminarayana Vogeti, Cynthia B. Leary, Lawrence Chun, Carol L. Ensinger
Publikováno v:
Molecular Cancer Therapeutics. 14:2023-2034
Altiratinib (DCC-2701) was designed based on the rationale of engineering a single therapeutic agent able to address multiple hallmarks of cancer (1). Specifically, altiratinib inhibits not only mechanisms of tumor initiation and progression, but als
Autor:
Karen A. Yates, H. S. Amorim, S. Salem-Sugui, Hai-Hu Wen, Luis Ghivelder, Shyam Sundar, L. F. Cohen
Publikováno v:
Physical Review B. 95
We report a detailed study of isofield magnetic relaxation and isothermal magnetization measurements with $H\ensuremath{\parallel}c$ on an underdoped ${\mathrm{Ba}}_{0.75}{\mathrm{K}}_{0.25}{\mathrm{Fe}}_{2}{\mathrm{As}}_{2}$ pnictide single crystal,
Publikováno v:
Journal of Alloys and Compounds. 509:6350-6353
Thick FeSe films (1–2 μm) were grown from high temperature solution with SeSn as the flux. Electron backscatter diffraction confirmed the films of tetragonal β phase with high crystallinity. Superconducting transition was observed by magnetic mea