Zobrazeno 1 - 10
of 239
pro vyhledávání: '"Karen A. West"'
Autor:
Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-5 (2024)
Abstract This letter demonstrates the potential of novel cryptic proteins resulting from TAR DNA-binding protein 43 (TDP-43) dysfunction as markers of TDP-43 pathology in neurodegenerative diseases.
Externí odkaz:
https://doaj.org/article/a36e0957494842178bf60c68ee7aa96b
Autor:
Anna Calliari, Lillian M. Daughrity, Ellen A. Albagli, Paula Castellanos Otero, Mei Yue, Karen Jansen-West, Naeyma N. Islam, Thomas Caulfield, Bailey Rawlinson, Michael DeTure, Casey Cook, Neill R. Graff-Radford, Gregory S. Day, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Keith A. Josephs, Björn Oskarsson, Aaron D. Gitler, Dennis W. Dickson, Tania F. Gendron, Mercedes Prudencio, Michael E. Ward, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/9628565cd0fc43dc81e3535e124ec483
Autor:
Virginia Estades Ayuso, Sarah Pickles, Tiffany Todd, Mei Yue, Karen Jansen-West, Yuping Song, Jesús González Bejarano, Bailey Rawlinson, Michael DeTure, Neill R. Graff-Radford, Bradley F. Boeve, David S. Knopman, Ronald C. Petersen, Dennis W. Dickson, Keith A. Josephs, Leonard Petrucelli, Mercedes Prudencio
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-13 (2023)
Abstract Background Inclusions of TAR DNA-binding protein 43 kDa (TDP-43) has been designated limbic-predominant, age-related TDP-43 encephalopathy (LATE), with or without co-occurrence of Alzheimer’s disease (AD). Approximately, 30–70% AD cases
Externí odkaz:
https://doaj.org/article/765c9c065e074bc09fdeae894bd6d350
Autor:
Sarah Pickles, Desiree Zanetti Alepuz, Yuka Koike, Mei Yue, Jimei Tong, Pinghu Liu, Yugui Zhou, Karen Jansen-West, Lillian M. Daughrity, Yuping Song, Michael DeTure, Björn Oskarsson, Neill R. Graff-Radford, Bradley F. Boeve, Ronald C. Petersen, Keith A. Josephs, Dennis W. Dickson, Michael E. Ward, Lijin Dong, Mercedes Prudencio, Casey N. Cook, Leonard Petrucelli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Treatments for neurodegenerative disease, including Frontotemporal dementia (FTD) and Amyotrophic lateral sclerosis (ALS), remain rather limited, underscoring the need for greater mechanistic insight and disease-relevant models. Our ability to develo
Externí odkaz:
https://doaj.org/article/f5770006374045b4827be986a2b16eba
Autor:
Jinyoung Park, Yanwei Wu, Wei Shao, Tania F. Gendron, Sophie J.F. van der Spek, Grigorii Sultanakhmetov, Avik Basu, Paula Castellanos Otero, Caroline J. Jones, Karen Jansen-West, Lillian M. Daughrity, Sadhna Phanse, Giulia del Rosso, Jimei Tong, Monica Castanedes-Casey, Lulu Jiang, Jenna Libera, Björn Oskarsson, Dennis W. Dickson, David W. Sanders, Clifford P. Brangwynne, Andrew Emili, Benjamin Wolozin, Leonard Petrucelli, Yong-Jie Zhang
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112822- (2023)
Summary: C9orf72 repeat expansions are the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). Poly(GR) proteins are toxic to neurons by forming cytoplasmic inclusions that sequester RNA-binding protein
Externí odkaz:
https://doaj.org/article/b8020317518447719952eee97c008bca
Autor:
Yuka Koike, Sarah Pickles, Virginia Estades Ayuso, Karen Jansen-West, Yue A Qi, Ziyi Li, Lillian M Daughrity, Mei Yue, Yong-Jie Zhang, Casey N Cook, Dennis W Dickson, Michael Ward, Leonard Petrucelli, Mercedes Prudencio
Publikováno v:
PLoS Biology, Vol 21, Iss 3, p e3002028 (2023)
A major function of TAR DNA-binding protein-43 (TDP-43) is to repress the inclusion of cryptic exons during RNA splicing. One of these cryptic exons is in UNC13A, a genetic risk factor for amyotrophic lateral sclerosis (ALS) and frontotemporal dement
Externí odkaz:
https://doaj.org/article/c620da5c535e493fbf35161ed1b10532
Autor:
Tiffany W. Todd, Zachary T. McEachin, Jeannie Chew, Alexander R. Burch, Karen Jansen-West, Jimei Tong, Mei Yue, Yuping Song, Monica Castanedes-Casey, Aishe Kurti, Judith H. Dunmore, John D. Fryer, Yong-Jie Zhang, Beatriz San Millan, Susana Teijeira Bautista, Manuel Arias, Dennis Dickson, Tania F. Gendron, María-Jesús Sobrido, Matthew D. Disney, Gary J. Bassell, Wilfried Rossoll, Leonard Petrucelli
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: A G4C2 hexanucleotide repeat expansion in an intron of C9orf72 is the most common cause of frontal temporal dementia and amyotrophic lateral sclerosis (c9FTD/ALS). A remarkably similar intronic TG3C2 repeat expansion is associated with spino
Externí odkaz:
https://doaj.org/article/a1385bc8f994442d9c1094bb8a16c0d4
Autor:
Wei Shao, Tiffany W. Todd, Yanwei Wu, Caroline Y. Jones, Jimei Tong, Karen Jansen-West, Lillian M. Daughrity, Jinyoung Park, Yuka Koike, Aishe Kurti, Mei Yue, Monica Castanedes-Casey, Giulia del Rosso, Judith A. Dunmore, Desiree Zanetti Alepuz, Björn Oskarsson, Dennis W. Dickson, Casey N. Cook, Mercedes Prudencio, Tania F. Gendron, John D. Fryer, Yong-Jie Zhang, Leonard Petrucelli
Publikováno v:
Science. 378:94-99
Frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS) are associated with both a repeat expansion in the C9orf72 gene and mutations in the TANK-binding kinase 1 ( TBK1 ) gene. We found that TBK1 is phosphorylated in response to C9orf72
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28515e918d894676744deafbd4c2c0b0
https://doi.org/10.1126/science.abq7860
https://doi.org/10.1126/science.abq7860
Publikováno v:
Journal of Dental Education. 86:1405-1417
This study examines the journey of US dental schools' predoctoral senior class of 2022, from the influences on and their motivations to pursue careers in dentistry, the aspects of their dental school experiences, plans upon graduation, and the invest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f51eaeeb65688063e08ed3397d212f15
https://doi.org/10.1002/jdd.13116
https://doi.org/10.1002/jdd.13116
Publikováno v:
Journal of Dental Education. 86:1259-1262
The purpose of the American Dental Education Association (ADEA) President's Symposium on men of color in the health professions, hosted at the 2022 ADEA Annual Session and Exhibition, was to draw attention to the need to address the low numbers of me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7619e4b41b62ddae3187b958b075fd34
https://doi.org/10.1002/jdd.13075
https://doi.org/10.1002/jdd.13075