Výsledky vyhledávání - "Karen A. Sap"

Akademický článek

Ubiquitin-modifying enzymes in Huntington’s disease

Autor: Karen A. Sap, Karlijne W. Geijtenbeek, Sabine Schipper-Krom, Arzu Tugce Guler, Eric A. Reits

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Huntington’s disease (HD) is a neurodegenerative disorder caused by a CAG repeat expansion in the N-terminus of the HTT gene. The CAG repeat expansion translates into a polyglutamine expansion in the mutant HTT (mHTT) protein, resulting in intracel

Externí odkaz: https://doaj.org/article/576b86218c654a1395268ed554130072

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Akademický článek

Strategies to Investigate Ubiquitination in Huntington's Disease

Autor: Karen A. Sap, Eric A. Reits

Publikováno v: Frontiers in Chemistry, Vol 8 (2020)

Many neurodegenerative disorders including Huntington's Disease are hallmarked by intracellular protein aggregates that are decorated by ubiquitin and different ubiquitin ligases and deubiquitinating enzymes. The protein aggregates observed in Huntin

Externí odkaz: https://doaj.org/article/ecf7375bf6ad4b3f86d4bd52e1317800

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Identification of Full-Length Wild-Type and Mutant Huntingtin Interacting Proteins by Crosslinking Immunoprecipitation in Mice Brain Cortex

Autor: Aleksandra E. Bury, Eric Reits, Karen A. Sap, Arzu Tugce Guler, Dick H. W. Dekkers, Jeroen Demmers

Publikováno v: Journal of Huntington's Disease
Journal of Huntington's disease, 10(3), 335-347. IOS Press BV

Background: Huntington’s disease is a neurodegenerative disorder caused by a CAG expansion in the huntingtin gene, resulting in a polyglutamine expansion in the ubiquitously expressed mutant huntingtin protein. Objective: Here we set out to identif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a753ea9ad6c63933fd095c82fd02095c
http://europepmc.org/articles/PMC8609692

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Global Proteome and Ubiquitinome Changes in the Soluble and Insoluble Fractions of Q175 Huntington Mice Brains

Autor: Aleksandra E. Bury, Jeroen Demmers, Arzu Tugce Guler, Eric Reits, Karen A. Sap, Katrin Juenemann, Karel Bezstarosti

Publikováno v: Molecular & Cellular Proteomics, 18(9), 1705-1720. American Society for Biochemistry and Molecular Biology Inc.
Molecular & cellular proteomics, 18(9), 1705-1720. American Society for Biochemistry and Molecular Biology Inc.
Mol Cell Proteomics

Huntington's disease is caused by a polyglutamine repeat expansion in the huntingtin protein which affects the function and folding of the protein, and results in intracellular protein aggregates. Here, we examined whether this mutation leads to alte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f359e4cd097ca81215f3aa9ce96a8dc
https://hdl.handle.net/1765/121206

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Strategies to Investigate Ubiquitination in Huntingtons Disease

Autor: Eric Reits, Karen A. Sap

Publikováno v: Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f7e14a7a89f3aada5f0b8f7a18519fd

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Improvement of ubiquitylation site detection by Orbitrap mass spectrometry

Autor: Ype Elgersma, Lennart van der Wal, Jeroen Demmers, Erikjan Rijkers, Karel Bezstarosti, Edwin Mientjes, Dick H. W. Dekkers, Karen A. Sap

Publikováno v: Journal of Proteomics, 172, 49-56. Elsevier
Journal of proteomics, 172, 49-56. Elsevier

Ubiquitylation is an important posttranslational protein modification that is involved in many cellular events. Immunopurification of peptides containing a K-e-diglycine (diGly) remnant as a mark of ubiquitylation combined with mass spectrometric det

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f86ad4e35698ef5aac27b35d6b9eeb
https://pure.eur.nl/en/publications/36b7073c-b610-4081-b499-bacd854b98cd

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Global quantitative proteomics reveals novel factors in the ecdysone signaling pathway in Drosophila melanogaster

Autor: Mirjam C G N van den Hout, Karel Bezstarosti, Karen A. Sap, Erikjan Rijkers, Jeroen Demmers, Wilfred F. J. van IJcken, Dick H. W. Dekkers

Publikováno v: Proteomics, 15(4), 725-738. Wiley-VCH Verlag
Proteomics, 15(4), 725-738. Wiley-VCH

The ecdysone signaling pathway plays a major role in various developmental transitions in insects. Recent advances in the understanding of ecdysone action have relied to a large extent on the application of molecular genetic tools in Drosophila. Here

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4091ef5ca1d9eb5694edbe2ae43831
https://hdl.handle.net/1765/81741

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Quantitative Proteomics Reveals Extensive Changes in the Ubiquitinome after Perturbation of the Proteasome by Targeted dsRNA-Mediated Subunit Knockdown in Drosophila

Autor: Dick H. W. Dekkers, Jeroen Demmers, Olaf Voets, Karel Bezstarosti, Karen A. Sap

Publikováno v: Journal of Proteome Research, 16(8), 2848-2862. American Chemical Society
Journal of proteome research, 16(8), 2848-2862. American Chemical Society

The ubiquitin-proteasome system (UPS), a highly regulated mechanism including the active marking of proteins by ubiquitin to be degraded, is critical in regulating proteostasis. Dysfunctioning of the UPS has been implicated in diseases such as cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfa5afed5678a95cfc8d9293714a8fe9
https://pure.eur.nl/en/publications/52373375-d8f2-4192-bc4c-232aafb8ec54

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Histone Chaperone NAP1 Mediates Sister Chromatid Resolution by Counteracting Protein Phosphatase 2A

Autor: Karen A. Sap, C. Peter Verrijzer, Zeliha Ozgur, Jeroen Demmers, Tsung Wai Kan, Gillian E. Chalkley, Wilfred F. J. van IJcken, Cécile M. Doyen, Yuri M. Moshkin, Karel Bezstarosti

Publikováno v: PLoS Genetics (print), 9(9). Public Library of Science
PLoS Genetics, Vol 9, Iss 9, p e1003719 (2013)
PLoS genetics, 9(9):e1003719. Public Library of Science
PLoS Genetics

Chromosome duplication and transmission into daughter cells requires the precisely orchestrated binding and release of cohesin. We found that the Drosophila histone chaperone NAP1 is required for cohesin release and sister chromatid resolution during

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::709cb64fd430d854ec89c45a0942c2b2
https://pure.eur.nl/en/publications/0e9c1326-9119-40d4-8c23-a4cef58a63d6

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Labeling Methods in Mass Spectrometry Based Quantitative Proteomics

Autor: Jeroen Demmers, Karen A. Sap

Proteomics is loosely defined as the description of sets of proteins from any biological source, which have in most cases been identified by using mass spectrometry. However, only the mere identity of proteins present in a certain sample does not giv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f61e6b9737e3fd012ab072cd260c4bd0
https://doi.org/10.5772/32489

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