Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Karen A. Litwa"'
Autor:
Regina F. Fernandez, Andrea S. Pereyra, Victoria Diaz, Emily S. Wilson, Karen A. Litwa, Jonatan Martínez-Gardeazabal, Shelley N. Jackson, J. Thomas Brenna, Brian P. Hermann, Jeffrey B. Eells, Jessica M. Ellis
Publikováno v:
JCI Insight, Vol 6, Iss 11 (2021)
The omega-3 fatty acid docosahexaenoic acid (DHA) inversely relates to neurological impairments with aging; however, limited nondietary models manipulating brain DHA have hindered a direct linkage. We discovered that loss of long-chain acyl-CoA synth
Externí odkaz:
https://doaj.org/article/324c8c40f386458cb32260dddf059dfd
Autor:
Samuel Martin-Vilchez, Leanna Whitmore, Hannelore Asmussen, Jessica Zareno, Rick Horwitz, Karen Newell-Litwa
Publikováno v:
PLoS ONE, Vol 12, Iss 1, p e0170464 (2017)
Small RhoGTPases regulate changes in post-synaptic spine morphology and density that support learning and memory. They are also major targets of synaptic disorders, including Autism. Here we sought to determine whether upstream RhoGTPase regulators,
Externí odkaz:
https://doaj.org/article/483608b0e4d246cab67933410726fa5d
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::564f0369f0995d795bd378af2c5d42b8
https://doi.org/10.1096/fasebj.2022.36.s1.r5219
https://doi.org/10.1096/fasebj.2022.36.s1.r5219
Autor:
Emily S Wilson, Karen A Litwa
Publikováno v:
Cells, Vol 10, Iss 2574, p 2574 (2021)
Cells
Volume 10
Issue 10
Cells
Volume 10
Issue 10
The hyaluronan-based extracellular matrix is expressed throughout nervous system development and is well-known for the formation of perineuronal nets around inhibitory interneurons. Since perineuronal nets form postnatally, the role of hyaluronan in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::536fc647b706731a74467e75e1f44fe9
https://www.mdpi.com/2073-4409/10/10/2574
https://www.mdpi.com/2073-4409/10/10/2574
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Scientific Reports
Scientific Reports
The endocannabinoid system (ECS) plays a complex role in the development of neural circuitry during fetal brain development. The cannabinoid receptor type 1 (CB1) controls synaptic strength at both excitatory and inhibitory synapses and thus contribu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a9817f54870393a282cdd34e8704bc
https://doi.org/10.1038/s41598-021-88750-2
https://doi.org/10.1038/s41598-021-88750-2
Autor:
Jeffrey B. Eells, Regina F. Fernandez, Karen A Litwa, Brian P. Hermann, J. Thomas Brenna, Shelley N. Jackson, Jessica M. Ellis, Jonatan Martínez-Gardeazabal, Victoria D. Diaz, Emily S Wilson, Andrea S. Pereyra
Publikováno v:
JCI Insight
The omega-3 fatty acid docosahexaenoic acid (DHA) inversely relates to neurological impairments with aging; however, limited nondietary models manipulating brain DHA have hindered a direct linkage. We discovered that loss of long-chain acyl-CoA synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e818bbf8bc795a1c0f52e3157ca18924
https://pubmed.ncbi.nlm.nih.gov/34100386
https://pubmed.ncbi.nlm.nih.gov/34100386
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Neurodevelopmental disorders present with synaptic alterations that disrupt the balance between excitatory and inhibitory signaling. For example, hyperexcitability of cortical neurons is associated with both epilepsy and autism spectrum disorders. Ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a59d3e9b90af23baf49c5a572bd83f56
https://doi.org/10.1038/s41598-020-73177-y
https://doi.org/10.1038/s41598-020-73177-y
Autor:
Emily S Wilson, Karen Newell-Litwa
Publikováno v:
Molecular Biology of the Cell
Many brain disorders exhibit altered synapse formation in development or synapse loss with age. To understand the complexities of human synapse development and degeneration, scientists now engineer neurons and brain organoids from human-induced pluri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1408469d1524af2b0cd5ad9e3cd4cd
http://europepmc.org/articles/PMC6329912
http://europepmc.org/articles/PMC6329912
Autor:
Jennifer L Hodges, Karen Newell-Litwa, Hannelore Asmussen, Miguel Vicente-Manzanares, Alan Rick Horwitz
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e24149 (2011)
Dendritic spines in hippocampal neurons mature from a filopodia-like precursor into a mushroom-shape with an enlarged post-synaptic density (PSD) and serve as the primary post-synaptic location of the excitatory neurotransmission that underlies learn
Externí odkaz:
https://doaj.org/article/dcab1a67924a4572a1dab2330ad30851