Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Karen A. Hartnett"'
Autor:
Qing Bai, Enhua Shao, Denglei Ma, Binxuan Jiao, Seth D. Scheetz, Karen A. Hartnett-Scott, Vladimir A. Ilin, Elias Aizenman, Julia Kofler, Edward A. Burton
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Progressive supranuclear palsy (PSP) is an incurable neurodegenerative disease characterized by 4-repeat (0N/4R)-Tau protein accumulation in CNS neurons. We generated transgenic zebrafish expressing human 0N/4R-Tau to investigate PSP pathoph
Externí odkaz:
https://doaj.org/article/8830819a9bf74daa9a3baec147b6c3a3
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Mutations in N-methyl-d-aspartate receptors (NMDAR) subunits have been implicated in a growing number of human neurodevelopmental disorders. Previously, a de novo mutation in GRIN2A, encoding the GluN2A subunit, was identified in a patient with sever
Externí odkaz:
https://doaj.org/article/4288fef1630e46d9bd186b464f6df8b6
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Frontiers in Pharmacology
Frontiers in Pharmacology
Mutations in N-methyl-d-aspartate receptors (NMDAR) subunits have been implicated in a growing number of human neurodevelopmental disorders. Previously, a de novo mutation in GRIN2A, encoding the GluN2A subunit, was identified in a patient with sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72b54ce1161d1b9eac31db8787772029
https://doi.org/10.3389/fphar.2021.773455
https://doi.org/10.3389/fphar.2021.773455
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129498 (2015)
Caspase activity during apoptosis is inhibited by physiological concentrations of intracellular K+. To enable apoptosis in injured cortical and hippocampal neurons, cellular loss of this cation is facilitated by the insertion of Kv2.1 K+ channels int
Externí odkaz:
https://doaj.org/article/b31c28dea11047b88c78de71a479426f
Autor:
Karen A. Hartnett, Kai He, Jason A. Justice, Elias Aizenman, Anthony J. Schulien, Niyathi H. Shah
Publikováno v:
Neuroscience. 354:158-167
As the predominant mediator of the delayed rectifier current, KV2.1 is an important regulator of neuronal excitability. KV2.1, however, also plays a well-established role in apoptotic cell death. Apoptogenic stimuli induce syntaxin-dependent traffick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97b944c52006bcd4ec09d102d7dc9f09
https://doi.org/10.1016/j.neuroscience.2017.04.034
https://doi.org/10.1016/j.neuroscience.2017.04.034
Autor:
Dandan Sun, Aubin Moutal, Charles T. Anderson, Rajesh Khanna, Thanos Tzounopoulos, Ashlyn M. Bulas, Karen A. Hartnett, Jami L. Saloman, Chung Yang Yeh, Elias Aizenman
Publikováno v:
The Journal of Neuroscience. 37:5648-5658
The voltage-gated K+ channel Kv2.1 has been intimately linked with neuronal apoptosis. After ischemic, oxidative, or inflammatory insults, Kv2.1 mediates a pronounced, delayed enhancement of K+ efflux, generating an optimal intracellular environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf285c49376fb67a52fc6e014142796
https://doi.org/10.1523/jneurosci.3811-16.2017
https://doi.org/10.1523/jneurosci.3811-16.2017
Autor:
Carlos J. Camacho, Rajesh Khanna, Zhaofeng Ye, Thanos Tzounopoulos, Stylianos Kouvaros, Jami L. Saloman, Elias Aizenman, Chung Yang Yeh, Aubin Moutal, Shivani Gaur, Karen A. Hartnett-Scott, Amanda M. Henton
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 116(31)
The neuronal cell death-promoting loss of cytoplasmic K(+) following injury is mediated by an increase in Kv2.1 potassium channels in the plasma membrane. This phenomenon relies on Kv2.1 binding to syntaxin 1A via 9 amino acids within the channel int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d8e368d75c3fdd486b4f0215d102eae
https://pubmed.ncbi.nlm.nih.gov/31308225
https://pubmed.ncbi.nlm.nih.gov/31308225
Autor:
Shalom Mammen, Gabrielle J. Kosobucki, Chung-Yang Yeh, Elias Aizenman, Michael J. Palladino, Daniel T. Manjooran, Anthony J. Schulien, Jason A. Justice, Karen A. Hartnett-Scott
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 367(2)
We present the design of an innovative molecular neuroprotective strategy and provide proof-of-concept for its implementation, relying on the injury-mediated activation of an ectopic gene construct. As oxidative injury leads to the intracellular libe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::148c3d32cac69ff95f61adcd81e561d8
https://pubmed.ncbi.nlm.nih.gov/30190339
https://pubmed.ncbi.nlm.nih.gov/30190339
Autor:
Elias Aizenman, Karen A. Hartnett, Kai He, Paul H. M. Kullmann, Ilana Lotan, John P. Horn, Meghan C. McCord
Publikováno v:
The Journal of Physiology. 592:3511-3521
Key points K+ efflux through newly membrane-inserted voltage-gated Kv2.1 K+ channels precedes neuronal apoptosis. In this study, we show that the binding site of the soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::24fdbc1c5da66603f895bb1b88d38d55
https://doi.org/10.1113/jphysiol.2014.276964
https://doi.org/10.1113/jphysiol.2014.276964
Autor:
Jason A, Justice, Anthony J, Schulien, Kai, He, Karen A, Hartnett, Elias, Aizenman, Niyathi H, Shah
Publikováno v:
Neuroscience. 354
As the predominant mediator of the delayed rectifier current, KV2.1 is an important regulator of neuronal excitability. KV2.1, however, also plays a well-established role in apoptotic cell death. Apoptogenic stimuli induce syntaxin-dependent traffick
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a9c1983501d30d66e6b769e61f92175
https://pubmed.ncbi.nlm.nih.gov/28461216
https://pubmed.ncbi.nlm.nih.gov/28461216